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Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats.

Abstract

This research analyzed the major chemical components and multiple antioxidant activities present in the fresh juice of eight vegetables, and studied their influence on starch induced postprandial glycemia in rats. A SDS-PAGE based protein fingerprint of each vegetable juice was also prepared. The yields of juice, chemical components like total proteins, total polyphenols, total flavonoids, total anthocyanins and free radicals like the ABTS˙(+) cation, DPPH, H(2)O(2), scavenging activities and reducing properties for NBT and FeCl(3) showed wide variations. Vegetable juice from brinjal ranked first in displaying total antioxidant capacity. Pretreatment of rats with vegetable juices moderated starch induced postprandial glycemia. The fresh juice from the vegetables ridge gourd, bottle gourd, ash gourd and chayote significantly mitigated postprandial hyperglycemic excursion. Total polyphenol concentrations present in vegetable juices positively influenced ABTS˙(+) scavenging activity and total antioxidant capacity. However, NBT reducing activity of juices was positively affected by total protein concentration. Contrarily, however, high polyphenol content in vegetable juice was observed to adversely affect the postprandial antihyperglycemic activity of vegetable juices. This is the first report exploring antihyperglycemic activity in these vegetable juices and highlights the possible adverse influence of high polyphenol content on the antihyperglycemic activity of the vegetable juices.

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  • Authors+Show Affiliations

    ,

    Pharmacology Division, Indian Institute of Chemical Technology (CSIR), Hyderabad, 500607, India. tiwari@iict.res.in

    , , , , ,

    Source

    Food & function 2:9 2011 Sep pg 521-8

    MeSH

    Animals
    Antioxidants
    Beverages
    Female
    Flavonoids
    Free Radical Scavengers
    Hyperglycemia
    Male
    Rats
    Rats, Wistar
    Starch
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21874188

    Citation

    Tiwari, Ashok K., et al. "Influence of Antioxidant Rich Fresh Vegetable Juices On Starch Induced Postprandial Hyperglycemia in Rats." Food & Function, vol. 2, no. 9, 2011, pp. 521-8.
    Tiwari AK, Reddy KS, Radhakrishnan J, et al. Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats. Food Funct. 2011;2(9):521-8.
    Tiwari, A. K., Reddy, K. S., Radhakrishnan, J., Kumar, D. A., Zehra, A., Agawane, S. B., & Madhusudana, K. (2011). Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats. Food & Function, 2(9), pp. 521-8. doi:10.1039/c1fo10093a.
    Tiwari AK, et al. Influence of Antioxidant Rich Fresh Vegetable Juices On Starch Induced Postprandial Hyperglycemia in Rats. Food Funct. 2011;2(9):521-8. PubMed PMID: 21874188.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats. AU - Tiwari,Ashok K, AU - Reddy,K Srikanth, AU - Radhakrishnan,Janani, AU - Kumar,D Anand, AU - Zehra,Amtul, AU - Agawane,Sachin B, AU - Madhusudana,K, Y1 - 2011/08/26/ PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/1/19/medline SP - 521 EP - 8 JF - Food & function JO - Food Funct VL - 2 IS - 9 N2 - This research analyzed the major chemical components and multiple antioxidant activities present in the fresh juice of eight vegetables, and studied their influence on starch induced postprandial glycemia in rats. A SDS-PAGE based protein fingerprint of each vegetable juice was also prepared. The yields of juice, chemical components like total proteins, total polyphenols, total flavonoids, total anthocyanins and free radicals like the ABTS˙(+) cation, DPPH, H(2)O(2), scavenging activities and reducing properties for NBT and FeCl(3) showed wide variations. Vegetable juice from brinjal ranked first in displaying total antioxidant capacity. Pretreatment of rats with vegetable juices moderated starch induced postprandial glycemia. The fresh juice from the vegetables ridge gourd, bottle gourd, ash gourd and chayote significantly mitigated postprandial hyperglycemic excursion. Total polyphenol concentrations present in vegetable juices positively influenced ABTS˙(+) scavenging activity and total antioxidant capacity. However, NBT reducing activity of juices was positively affected by total protein concentration. Contrarily, however, high polyphenol content in vegetable juice was observed to adversely affect the postprandial antihyperglycemic activity of vegetable juices. This is the first report exploring antihyperglycemic activity in these vegetable juices and highlights the possible adverse influence of high polyphenol content on the antihyperglycemic activity of the vegetable juices. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/21874188/Influence_of_antioxidant_rich_fresh_vegetable_juices_on_starch_induced_postprandial_hyperglycemia_in_rats_ L2 - https://doi.org/10.1039/c1fo10093a DB - PRIME DP - Unbound Medicine ER -