Prime

Type your tag names separated by a space and hit enter

Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, The University of Ulster, Northern Ireland BT52 1SA, United Kingdom.

    , , , , ,

    Source

    Bioorganic & medicinal chemistry letters 21:19 2011 Oct 1 pg 5750-2

    MeSH

    Animals
    CHO Cells
    Cell Death
    Cell Line, Tumor
    Cell Survival
    Cricetinae
    Drug Evaluation, Preclinical
    Lethal Dose 50
    Light
    Methylene Blue
    Oxidation-Reduction
    Photosensitizing Agents
    Reactive Oxygen Species
    Rose Bengal
    Sound

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21875807

    Citation

    TY - JOUR T1 - Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. AU - McCaughan,Bridgeen, AU - Rouanet,Claire, AU - Fowley,Colin, AU - Nomikou,Nikolitsa, AU - McHale,Anthony P, AU - McCarron,Paul A, AU - Callan,John F, Y1 - 2011/08/10/ PY - 2011/7/6/received PY - 2011/8/1/revised PY - 2011/8/2/accepted PY - 2011/8/10/aheadofprint PY - 2011/8/31/entrez PY - 2011/8/31/pubmed PY - 2012/4/17/medline SP - 5750 EP - 2 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 21 IS - 19 N2 - A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/21875807/Enhanced_ROS_production_and_cell_death_through_combined_photo__and_sono_activation_of_conventional_photosensitising_drugs_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(11)01100-0 ER -