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Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.
A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.
Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, The University of Ulster, Northern Ireland BT52 1SA, United Kingdom., , , , ,
Cell Line, Tumor
Drug Evaluation, Preclinical
Lethal Dose 50
Reactive Oxygen Species
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't