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Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.
Bioorg Med Chem Lett 2011; 21(19):5750-2BM

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

Authors+Show Affiliations

Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, The University of Ulster, Northern Ireland BT52 1SA, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21875807

Citation

McCaughan, Bridgeen, et al. "Enhanced ROS Production and Cell Death Through Combined Photo- and Sono-activation of Conventional Photosensitising Drugs." Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 19, 2011, pp. 5750-2.
McCaughan B, Rouanet C, Fowley C, et al. Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. Bioorg Med Chem Lett. 2011;21(19):5750-2.
McCaughan, B., Rouanet, C., Fowley, C., Nomikou, N., McHale, A. P., McCarron, P. A., & Callan, J. F. (2011). Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. Bioorganic & Medicinal Chemistry Letters, 21(19), pp. 5750-2. doi:10.1016/j.bmcl.2011.08.015.
McCaughan B, et al. Enhanced ROS Production and Cell Death Through Combined Photo- and Sono-activation of Conventional Photosensitising Drugs. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5750-2. PubMed PMID: 21875807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. AU - McCaughan,Bridgeen, AU - Rouanet,Claire, AU - Fowley,Colin, AU - Nomikou,Nikolitsa, AU - McHale,Anthony P, AU - McCarron,Paul A, AU - Callan,John F, Y1 - 2011/08/10/ PY - 2011/07/06/received PY - 2011/08/01/revised PY - 2011/08/02/accepted PY - 2011/8/31/entrez PY - 2011/8/31/pubmed PY - 2012/4/17/medline SP - 5750 EP - 2 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 21 IS - 19 N2 - A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/21875807/Enhanced_ROS_production_and_cell_death_through_combined_photo__and_sono_activation_of_conventional_photosensitising_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(11)01100-0 DB - PRIME DP - Unbound Medicine ER -