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Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies.
J Clin Oncol 2011; 29(28):3775-82JC

Abstract

PURPOSE

To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis.

METHODS

Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer. Approximately 1,000,000 participants from several countries were included in this analysis.

RESULTS

Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis. The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89).

CONCLUSION

Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis.

Authors+Show Affiliations

The Sixth People's Hospital affiliated with Shanghai Jiao Tong University, 600 Yishan Rd, Shanghai 200233, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

21876081

Citation

Ma, Yanlei, et al. "Association Between Vitamin D and Risk of Colorectal Cancer: a Systematic Review of Prospective Studies." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 29, no. 28, 2011, pp. 3775-82.
Ma Y, Zhang P, Wang F, et al. Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol. 2011;29(28):3775-82.
Ma, Y., Zhang, P., Wang, F., Yang, J., Liu, Z., & Qin, H. (2011). Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 29(28), pp. 3775-82. doi:10.1200/JCO.2011.35.7566.
Ma Y, et al. Association Between Vitamin D and Risk of Colorectal Cancer: a Systematic Review of Prospective Studies. J Clin Oncol. 2011 Oct 1;29(28):3775-82. PubMed PMID: 21876081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. AU - Ma,Yanlei, AU - Zhang,Peng, AU - Wang,Feng, AU - Yang,Jianjun, AU - Liu,Zhihua, AU - Qin,Huanlong, Y1 - 2011/08/29/ PY - 2011/8/31/entrez PY - 2011/8/31/pubmed PY - 2012/1/18/medline SP - 3775 EP - 82 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 29 IS - 28 N2 - PURPOSE: To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis. METHODS: Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer. Approximately 1,000,000 participants from several countries were included in this analysis. RESULTS: Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis. The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89). CONCLUSION: Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis. SN - 1527-7755 UR - https://www.unboundmedicine.com/medline/citation/21876081/full_citation L2 - http://ascopubs.org/doi/full/10.1200/JCO.2011.35.7566?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -