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Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies.

Abstract

PURPOSE

To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis.

METHODS

Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer. Approximately 1,000,000 participants from several countries were included in this analysis.

RESULTS

Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis. The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89).

CONCLUSION

Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis.

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  • Authors+Show Affiliations

    ,

    The Sixth People's Hospital affiliated with Shanghai Jiao Tong University, 600 Yishan Rd, Shanghai 200233, People's Republic of China.

    , , , ,

    Source

    MeSH

    Case-Control Studies
    Cohort Studies
    Colorectal Neoplasms
    Female
    Humans
    Male
    Prospective Studies
    Risk Factors
    Vitamin D

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    21876081

    Citation

    Ma, Yanlei, et al. "Association Between Vitamin D and Risk of Colorectal Cancer: a Systematic Review of Prospective Studies." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 29, no. 28, 2011, pp. 3775-82.
    Ma Y, Zhang P, Wang F, et al. Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol. 2011;29(28):3775-82.
    Ma, Y., Zhang, P., Wang, F., Yang, J., Liu, Z., & Qin, H. (2011). Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 29(28), pp. 3775-82. doi:10.1200/JCO.2011.35.7566.
    Ma Y, et al. Association Between Vitamin D and Risk of Colorectal Cancer: a Systematic Review of Prospective Studies. J Clin Oncol. 2011 Oct 1;29(28):3775-82. PubMed PMID: 21876081.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. AU - Ma,Yanlei, AU - Zhang,Peng, AU - Wang,Feng, AU - Yang,Jianjun, AU - Liu,Zhihua, AU - Qin,Huanlong, Y1 - 2011/08/29/ PY - 2011/8/31/entrez PY - 2011/8/31/pubmed PY - 2012/1/18/medline SP - 3775 EP - 82 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 29 IS - 28 N2 - PURPOSE: To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer using meta-analysis. METHODS: Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions. We included prospective studies that reported relative risk (RR) estimates with 95% CIs for the association between vitamin D intake or blood 25(OH)D levels and the risk of colorectal, colon, or rectal cancer. Approximately 1,000,000 participants from several countries were included in this analysis. RESULTS: Nine studies on vitamin D intake and nine studies on blood 25(OH)D levels were included in the meta-analysis. The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89). CONCLUSION: Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis. SN - 1527-7755 UR - https://www.unboundmedicine.com/medline/citation/21876081/full_citation L2 - http://ascopubs.org/doi/full/10.1200/JCO.2011.35.7566?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -