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Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss.
J Ethnopharmacol. 2011 Oct 11; 137(3):1469-76.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Byrsonima intermedia A. Juss. is popularly known as "murici pequeno" and is native to the Brazilian Cerrado. This species has been used as an antimicrobial, anti-hemorrhagic, anti-diarrheal and anti-inflammatory. Nevertheless, scientific information regarding Byrsonima intermedia is limited; there are no reports related to its possible anti inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Byrsonima intermedia.

MATERIALS AND METHODS

Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation tests were used to investigate the anti-inflammatory activity of Byrsonima intermedia aqueous extract (BiAE) in rats. Mechanical nociceptive paw, formalin and hot plate tests were used to evaluate the antinociceptive activity in mice. High-performance liquid chromatography (HPLC), phytochemistry screening and determination of total phenolics and flavonoids were used to determine the chemical profile of the BiAE.

RESULTS

BiAE at test doses of 30-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced carrageenan-induced paw edema, by inhibited leukocyte recruitment into the peritoneal cavity and, in the model of chronic inflammation, by using the cotton pellet-induced fibrovascular tissue growth in rats. The extracts at test doses of 30-300 mg/kg p.o. clearly demonstrated antinociceptive activity in all tests. Administration of the opioid receptor antagonist naloxone completely inhibited the antinociceptive effect induced by BiAE (100 mg/kg).

CONCLUSION

BiAE markedly exhibits anti-inflammatory action in rats and antinociceptive activity in mice. Thus, it may be useful in the treatment of inflammatory hyperalgesic disorders, which supports previous claims of its traditional use.

Authors+Show Affiliations

Department of Physiological Sciences, Institute of Biomedical Sciences, Federal University of Alfenas-MG, 37130-000 Alfenas, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21878381

Citation

Orlandi, Lidiane, et al. "Anti-inflammatory and Antinociceptive Effects of the Stem Bark of Byrsonima Intermedia A. Juss." Journal of Ethnopharmacology, vol. 137, no. 3, 2011, pp. 1469-76.
Orlandi L, Vilela FC, Santa-Cecília FV, et al. Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss. J Ethnopharmacol. 2011;137(3):1469-76.
Orlandi, L., Vilela, F. C., Santa-Cecília, F. V., Dias, D. F., Alves-da-Silva, G., & Giusti-Paiva, A. (2011). Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss. Journal of Ethnopharmacology, 137(3), 1469-76. https://doi.org/10.1016/j.jep.2011.08.032
Orlandi L, et al. Anti-inflammatory and Antinociceptive Effects of the Stem Bark of Byrsonima Intermedia A. Juss. J Ethnopharmacol. 2011 Oct 11;137(3):1469-76. PubMed PMID: 21878381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss. AU - Orlandi,Lidiane, AU - Vilela,Fabiana C, AU - Santa-Cecília,Flávia V, AU - Dias,Danielle F, AU - Alves-da-Silva,Geraldo, AU - Giusti-Paiva,Alexandre, Y1 - 2011/08/23/ PY - 2011/06/14/received PY - 2011/08/07/revised PY - 2011/08/14/accepted PY - 2011/9/1/entrez PY - 2011/9/1/pubmed PY - 2012/2/15/medline SP - 1469 EP - 76 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Byrsonima intermedia A. Juss. is popularly known as "murici pequeno" and is native to the Brazilian Cerrado. This species has been used as an antimicrobial, anti-hemorrhagic, anti-diarrheal and anti-inflammatory. Nevertheless, scientific information regarding Byrsonima intermedia is limited; there are no reports related to its possible anti inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Byrsonima intermedia. MATERIALS AND METHODS: Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation tests were used to investigate the anti-inflammatory activity of Byrsonima intermedia aqueous extract (BiAE) in rats. Mechanical nociceptive paw, formalin and hot plate tests were used to evaluate the antinociceptive activity in mice. High-performance liquid chromatography (HPLC), phytochemistry screening and determination of total phenolics and flavonoids were used to determine the chemical profile of the BiAE. RESULTS: BiAE at test doses of 30-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced carrageenan-induced paw edema, by inhibited leukocyte recruitment into the peritoneal cavity and, in the model of chronic inflammation, by using the cotton pellet-induced fibrovascular tissue growth in rats. The extracts at test doses of 30-300 mg/kg p.o. clearly demonstrated antinociceptive activity in all tests. Administration of the opioid receptor antagonist naloxone completely inhibited the antinociceptive effect induced by BiAE (100 mg/kg). CONCLUSION: BiAE markedly exhibits anti-inflammatory action in rats and antinociceptive activity in mice. Thus, it may be useful in the treatment of inflammatory hyperalgesic disorders, which supports previous claims of its traditional use. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21878381/Anti_inflammatory_and_antinociceptive_effects_of_the_stem_bark_of_Byrsonima_intermedia_A__Juss_ DB - PRIME DP - Unbound Medicine ER -