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A₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons.
Neuroreport. 2011 Oct 05; 22(14):711-5.N

Abstract

We have investigated the adenosine-mediated presynaptic inhibition of primary afferent-evoked glutamate release in rat substantia gelatinosa neurons of the trigeminal subnucleus caudalis using a conventional whole-cell patch clamp technique. Adenosine reversibly and concentration dependently decreased the amplitude of glutamatergic excitatory postsynaptic currents and increased the paired-pulse ratio, indicating that adenosine acts presynaptically to reduce glutamate release from primary afferents. The adenosine-induced inhibition of excitatory postsynaptic currents was occluded by a selective A₁ receptor antagonist, DPCPX, and was mimicked by a selective A₁ receptor agonist CPA. The results suggest that presynaptic A₁ receptors decrease action potential-dependent glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons, and thus adenosine A₁ receptors could be a potential target for the treatment of pain of orofacial tissues.

Authors+Show Affiliations

Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21878793

Citation

Choi, In-Sun, et al. "A₁ Receptors Inhibit Glutamate Release in Rat Medullary Dorsal Horn Neurons." Neuroreport, vol. 22, no. 14, 2011, pp. 711-5.
Choi IS, Cho JH, Jang IS. A₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport. 2011;22(14):711-5.
Choi, I. S., Cho, J. H., & Jang, I. S. (2011). A₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport, 22(14), 711-5. https://doi.org/10.1097/WNR.0b013e32834ab174
Choi IS, Cho JH, Jang IS. A₁ Receptors Inhibit Glutamate Release in Rat Medullary Dorsal Horn Neurons. Neuroreport. 2011 Oct 5;22(14):711-5. PubMed PMID: 21878793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons. AU - Choi,In-Sun, AU - Cho,Jin-Hwa, AU - Jang,Il-Sung, PY - 2011/9/1/entrez PY - 2011/9/1/pubmed PY - 2012/6/5/medline SP - 711 EP - 5 JF - Neuroreport JO - Neuroreport VL - 22 IS - 14 N2 - We have investigated the adenosine-mediated presynaptic inhibition of primary afferent-evoked glutamate release in rat substantia gelatinosa neurons of the trigeminal subnucleus caudalis using a conventional whole-cell patch clamp technique. Adenosine reversibly and concentration dependently decreased the amplitude of glutamatergic excitatory postsynaptic currents and increased the paired-pulse ratio, indicating that adenosine acts presynaptically to reduce glutamate release from primary afferents. The adenosine-induced inhibition of excitatory postsynaptic currents was occluded by a selective A₁ receptor antagonist, DPCPX, and was mimicked by a selective A₁ receptor agonist CPA. The results suggest that presynaptic A₁ receptors decrease action potential-dependent glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons, and thus adenosine A₁ receptors could be a potential target for the treatment of pain of orofacial tissues. SN - 1473-558X UR - https://www.unboundmedicine.com/medline/citation/21878793/A₁_receptors_inhibit_glutamate_release_in_rat_medullary_dorsal_horn_neurons_ L2 - http://dx.doi.org/10.1097/WNR.0b013e32834ab174 DB - PRIME DP - Unbound Medicine ER -