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[Hypovitaminosis D in pediatric patients on renal replacement therapy].
Rev Med Chil. 2011 Mar; 139(3):334-9.RM

Abstract

BACKGROUND

Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD).

AIM

To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation.

MATERIAL AND METHODS

Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51% females).

RESULTS

Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD: 21 ± 16.8, PD: 18.9 ± 8.5, Tx: 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04).

CONCLUSIONS

Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.

Authors+Show Affiliations

Departamento Pediatría y Cirugía Infantil Oriente, Universidad de Chile, Hospital Luis Calvo Mackenna, Santiago, Chile.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

spa

PubMed ID

21879165

Citation

Delucchi, Angela, et al. "[Hypovitaminosis D in Pediatric Patients On Renal Replacement Therapy]." Revista Medica De Chile, vol. 139, no. 3, 2011, pp. 334-9.
Delucchi A, Alarcón C, Cano F, et al. [Hypovitaminosis D in pediatric patients on renal replacement therapy]. Rev Med Chil. 2011;139(3):334-9.
Delucchi, A., Alarcón, C., Cano, F., Lillo, A. M., Guerrero, J. L., Azócar, M., Abarzúa, C., Muñoz, M. J., & Iñiguez, G. (2011). [Hypovitaminosis D in pediatric patients on renal replacement therapy]. Revista Medica De Chile, 139(3), 334-9. https://doi.org//S0034-98872011000300008
Delucchi A, et al. [Hypovitaminosis D in Pediatric Patients On Renal Replacement Therapy]. Rev Med Chil. 2011;139(3):334-9. PubMed PMID: 21879165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hypovitaminosis D in pediatric patients on renal replacement therapy]. AU - Delucchi,Angela, AU - Alarcón,Claudia, AU - Cano,Francisco, AU - Lillo,Ana María, AU - Guerrero,José Luis, AU - Azócar,Marta, AU - Abarzúa,Carolina, AU - Muñoz,María José, AU - Iñiguez,Germán, Y1 - 2011/08/25/ PY - 2011/9/1/entrez PY - 2011/9/1/pubmed PY - 2012/6/2/medline SP - 334 EP - 9 JF - Revista medica de Chile JO - Rev Med Chil VL - 139 IS - 3 N2 - BACKGROUND: Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD). AIM: To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. MATERIAL AND METHODS: Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51% females). RESULTS: Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD: 21 ± 16.8, PD: 18.9 ± 8.5, Tx: 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04). CONCLUSIONS: Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure. SN - 0717-6163 UR - https://www.unboundmedicine.com/medline/citation/21879165/[Hypovitaminosis_D_in_pediatric_patients_on_renal_replacement_therapy]_ L2 - http://www.scielo.cl/scielo.php?script=sci_arttext&amp;pid=S0034-98872011000300008&amp;lng=en&amp;nrm=iso&amp;tlng=en DB - PRIME DP - Unbound Medicine ER -