Tags

Type your tag names separated by a space and hit enter

Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats.
Mol Cell Biochem 2012; 360(1-2):51-60MC

Abstract

Antioxidants are one of the key players in tumorigenesis, several natural and synthetic antioxidants were shown to have anticancer effects. The aim of the present study is to divulge the chemopreventive nature of carvacrol during diethylnitrosamine (DEN)-induced liver cancer in male wistar albino rats. Administration of DEN to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and gamma glutamyl transpeptidase (γGT). The levels of lipid peroxides elevated (in both serum and tissue) with subsequent decrease in the final body weight and tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and glutathione reductase (GR). Carvacrol supplementation (15 mg/kg body weight) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer. Histological observations and transmission electron microscopy studies were also carried out, which added supports to the chemopreventive action of the carvacrol against DEN-induction during liver cancer progression. These findings suggest that carvacrol prevents lipid peroxidation, hepatic cell damage, and protects the antioxidant system in DEN-induced hepatocellular carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21879312

Citation

Jayakumar, Subramaniyan, et al. "Potential Preventive Effect of Carvacrol Against Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats." Molecular and Cellular Biochemistry, vol. 360, no. 1-2, 2012, pp. 51-60.
Jayakumar S, Madankumar A, Asokkumar S, et al. Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Mol Cell Biochem. 2012;360(1-2):51-60.
Jayakumar, S., Madankumar, A., Asokkumar, S., Raghunandhakumar, S., Gokula dhas, K., Kamaraj, S., ... Devaki, T. (2012). Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Molecular and Cellular Biochemistry, 360(1-2), pp. 51-60. doi:10.1007/s11010-011-1043-7.
Jayakumar S, et al. Potential Preventive Effect of Carvacrol Against Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats. Mol Cell Biochem. 2012;360(1-2):51-60. PubMed PMID: 21879312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. AU - Jayakumar,Subramaniyan, AU - Madankumar,Arumugam, AU - Asokkumar,Selvamani, AU - Raghunandhakumar,Subramanian, AU - Gokula dhas,Krishnan, AU - Kamaraj,Sattu, AU - Divya,Michael Georget Josephine, AU - Devaki,Thiruvengadam, Y1 - 2011/08/31/ PY - 2011/05/24/received PY - 2011/08/13/accepted PY - 2011/9/1/entrez PY - 2011/9/1/pubmed PY - 2012/3/23/medline SP - 51 EP - 60 JF - Molecular and cellular biochemistry JO - Mol. Cell. Biochem. VL - 360 IS - 1-2 N2 - Antioxidants are one of the key players in tumorigenesis, several natural and synthetic antioxidants were shown to have anticancer effects. The aim of the present study is to divulge the chemopreventive nature of carvacrol during diethylnitrosamine (DEN)-induced liver cancer in male wistar albino rats. Administration of DEN to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and gamma glutamyl transpeptidase (γGT). The levels of lipid peroxides elevated (in both serum and tissue) with subsequent decrease in the final body weight and tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and glutathione reductase (GR). Carvacrol supplementation (15 mg/kg body weight) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer. Histological observations and transmission electron microscopy studies were also carried out, which added supports to the chemopreventive action of the carvacrol against DEN-induction during liver cancer progression. These findings suggest that carvacrol prevents lipid peroxidation, hepatic cell damage, and protects the antioxidant system in DEN-induced hepatocellular carcinogenesis. SN - 1573-4919 UR - https://www.unboundmedicine.com/medline/citation/21879312/Potential_preventive_effect_of_carvacrol_against_diethylnitrosamine_induced_hepatocellular_carcinoma_in_rats_ L2 - https://doi.org/10.1007/s11010-011-1043-7 DB - PRIME DP - Unbound Medicine ER -