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Assessment of endometrial receptivity.
Fertil Steril 2011; 96(3):522-9FS

Abstract

OBJECTIVE

To provide a focused review of the scientific literature pertaining to endometrial receptivity.

DESIGN

Review of the literature and appraisal of relevant articles.

SETTING

Academic teaching hospital.

PATIENT(S)

Women with infertility.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Critical review of the literature.

RESULT(S)

Although a consensus has been achieved regarding the existence of a temporally defined period during which embryo attachment and invasion can occur (called the "window of implantation"), reliable methods to assess "receptivity" have not been established or adequately validated. In women with certain gynecologic disorders, including endometriosis, tubal disease, and polycystic ovary syndrome, endometrial receptivity seems to be compromised, leading to infertility and pregnancy loss. The establishment of reliable biomarkers for the detection of defects in endometrial receptivity has been a long-sought goal that remains an elusive target. The validation of endometrial biomarkers will require properly designed and implemented studies based on the recognition that endometrial receptivity defects are not equally distributed in women with endometriosis or these other conditions.

CONCLUSION(S)

Rapidly advancing technologies are bringing new biomarkers to the clinical arena that promise to further reveal the complexities of the implantation process.

Authors+Show Affiliations

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University Medical Group, Greenville Hospital System, Greenville, SC 29605, USA. blessey@ghs.org

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21880273

Citation

Lessey, Bruce A.. "Assessment of Endometrial Receptivity." Fertility and Sterility, vol. 96, no. 3, 2011, pp. 522-9.
Lessey BA. Assessment of endometrial receptivity. Fertil Steril. 2011;96(3):522-9.
Lessey, B. A. (2011). Assessment of endometrial receptivity. Fertility and Sterility, 96(3), pp. 522-9. doi:10.1016/j.fertnstert.2011.07.1095.
Lessey BA. Assessment of Endometrial Receptivity. Fertil Steril. 2011;96(3):522-9. PubMed PMID: 21880273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of endometrial receptivity. A1 - Lessey,Bruce A, PY - 2011/07/11/received PY - 2011/07/11/accepted PY - 2011/9/2/entrez PY - 2011/9/2/pubmed PY - 2011/11/9/medline SP - 522 EP - 9 JF - Fertility and sterility JO - Fertil. Steril. VL - 96 IS - 3 N2 - OBJECTIVE: To provide a focused review of the scientific literature pertaining to endometrial receptivity. DESIGN: Review of the literature and appraisal of relevant articles. SETTING: Academic teaching hospital. PATIENT(S): Women with infertility. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Critical review of the literature. RESULT(S): Although a consensus has been achieved regarding the existence of a temporally defined period during which embryo attachment and invasion can occur (called the "window of implantation"), reliable methods to assess "receptivity" have not been established or adequately validated. In women with certain gynecologic disorders, including endometriosis, tubal disease, and polycystic ovary syndrome, endometrial receptivity seems to be compromised, leading to infertility and pregnancy loss. The establishment of reliable biomarkers for the detection of defects in endometrial receptivity has been a long-sought goal that remains an elusive target. The validation of endometrial biomarkers will require properly designed and implemented studies based on the recognition that endometrial receptivity defects are not equally distributed in women with endometriosis or these other conditions. CONCLUSION(S): Rapidly advancing technologies are bringing new biomarkers to the clinical arena that promise to further reveal the complexities of the implantation process. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/21880273/Assessment_of_endometrial_receptivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(11)02192-3 DB - PRIME DP - Unbound Medicine ER -