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Comparison of characteristics, management practices, and outcomes of patients between the global registry and the gulf registry of acute coronary events.
Am J Cardiol. 2011 Nov 01; 108(9):1252-8.AJ

Abstract

The Arab Middle East is a unique region of the developing world where little is known about the outcomes of patients hospitalized with an acute coronary syndrome (ACS), despite playing an important role in the global burden of cardiovascular disease. The primary objectives of this observational study were to compare patients with ACS hospitalized in the Arab Middle East to patients enrolled in a multinational non-Arabian ACS registry. The study cohort consisted of patients hospitalized in 2007 with an ACS including 4,445 from the Global Registry of Acute Coronary Events (GRACE) and 6,706 from the Gulf Registry of Acute Coronary Events (Gulf RACE). Average age of patients in Gulf RACE was nearly a decade younger than that in GRACE (56 vs 66 years). Patients in Gulf RACE were more likely to be men, diabetic, and smoke and less likely to be hypertensive compared to patients in GRACE. Patients in Gulf RACE had higher odds of receiving aspirin and a lower likelihood of receiving angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β blockers, and clopidogrel during their index hospitalization. Although most eligible patients with ST-elevation myocardial infarction in Gulf RACE received thrombolytics, most of their counterparts in GRACE underwent a primary percutaneous coronary intervention. Multivariable adjusted in-hospital case-fatality rates were not significantly different between patients in Gulf RACE and those in GRACE. In conclusion, despite differences in patient characteristics and treatment practices, short-term mortality rates were comparable in patients with ACS enrolled in these 2 registries. Future studies should explore the effects of these differences on long-term prognosis and other pertinent patient outcomes.

Authors+Show Affiliations

University of Massachusetts, Medical School, Worcester, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21880292

Citation

Awad, Hamza H., et al. "Comparison of Characteristics, Management Practices, and Outcomes of Patients Between the Global Registry and the Gulf Registry of Acute Coronary Events." The American Journal of Cardiology, vol. 108, no. 9, 2011, pp. 1252-8.
Awad HH, Zubaid M, Alsheikh-Ali AA, et al. Comparison of characteristics, management practices, and outcomes of patients between the global registry and the gulf registry of acute coronary events. Am J Cardiol. 2011;108(9):1252-8.
Awad, H. H., Zubaid, M., Alsheikh-Ali, A. A., Al Suwaidi, J., Anderson, F. A., Gore, J. M., & Goldberg, R. J. (2011). Comparison of characteristics, management practices, and outcomes of patients between the global registry and the gulf registry of acute coronary events. The American Journal of Cardiology, 108(9), 1252-8. https://doi.org/10.1016/j.amjcard.2011.06.040
Awad HH, et al. Comparison of Characteristics, Management Practices, and Outcomes of Patients Between the Global Registry and the Gulf Registry of Acute Coronary Events. Am J Cardiol. 2011 Nov 1;108(9):1252-8. PubMed PMID: 21880292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of characteristics, management practices, and outcomes of patients between the global registry and the gulf registry of acute coronary events. AU - Awad,Hamza H, AU - Zubaid,Mohammad, AU - Alsheikh-Ali,Alawi A, AU - Al Suwaidi,Jassim, AU - Anderson,Frederick A,Jr AU - Gore,Joel M, AU - Goldberg,Robert J, Y1 - 2011/08/30/ PY - 2011/03/29/received PY - 2011/06/15/revised PY - 2011/06/15/accepted PY - 2011/9/2/entrez PY - 2011/9/2/pubmed PY - 2011/12/30/medline SP - 1252 EP - 8 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 108 IS - 9 N2 - The Arab Middle East is a unique region of the developing world where little is known about the outcomes of patients hospitalized with an acute coronary syndrome (ACS), despite playing an important role in the global burden of cardiovascular disease. The primary objectives of this observational study were to compare patients with ACS hospitalized in the Arab Middle East to patients enrolled in a multinational non-Arabian ACS registry. The study cohort consisted of patients hospitalized in 2007 with an ACS including 4,445 from the Global Registry of Acute Coronary Events (GRACE) and 6,706 from the Gulf Registry of Acute Coronary Events (Gulf RACE). Average age of patients in Gulf RACE was nearly a decade younger than that in GRACE (56 vs 66 years). Patients in Gulf RACE were more likely to be men, diabetic, and smoke and less likely to be hypertensive compared to patients in GRACE. Patients in Gulf RACE had higher odds of receiving aspirin and a lower likelihood of receiving angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β blockers, and clopidogrel during their index hospitalization. Although most eligible patients with ST-elevation myocardial infarction in Gulf RACE received thrombolytics, most of their counterparts in GRACE underwent a primary percutaneous coronary intervention. Multivariable adjusted in-hospital case-fatality rates were not significantly different between patients in Gulf RACE and those in GRACE. In conclusion, despite differences in patient characteristics and treatment practices, short-term mortality rates were comparable in patients with ACS enrolled in these 2 registries. Future studies should explore the effects of these differences on long-term prognosis and other pertinent patient outcomes. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/21880292/Comparison_of_characteristics_management_practices_and_outcomes_of_patients_between_the_global_registry_and_the_gulf_registry_of_acute_coronary_events_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(11)02232-6 DB - PRIME DP - Unbound Medicine ER -