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[Effect of OATP1B1 521T --> C heterogenesis on pharmacokinetic characterstics of rosuvastatin in Chinese volunteers].
Yao Xue Xue Bao. 2011 Jun; 46(6):695-700.YX

Abstract

This study is to report the effect of OATP1B1 gene mutation in the 521T --> C in Chinese human on the pharmacokinetics of rosuvastatin and guide the reasonable clinical application of rosuvastatin by the feature of genetic polymorphism of OATP1B1. Plasma samples were determined with LC-MS: the analyte and internal standard pitavastatin were both analyzed by MS in the ESI, m/z was 480.0 for rosuvastatin and 420.0 for the IS, separately. Genotyping of OATP1B1 was determined with the method of polymerase chain reaction--amplification refractory mutation system targeted at 40 healthy volunteers and showed that there were 7 subjects with 521T --> C mutant, accounting to 17.5% of total and wild type homozygote accounted to 82.5%. It was found that there were significant differences between OATP1B1 mutation in the 521T --> C and wild type homozygote for rosuvastatin pharmacokinetic process in Chinese human. In contrast to OATP1B1 wild type group, OATP1B1 mutation group's absorption degree increased, elimination process decreased. The OATP1B1 mutation should be noted for guiding the reasonable application of rosuvastatin during its clinical use.

Authors+Show Affiliations

Institute of Clinical Pharmacology, Medical College of Nanchang University, Nanchang 330006, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21882531

Citation

Sui, Shuang-Ming, et al. "[Effect of OATP1B1 521T --> C Heterogenesis On Pharmacokinetic Characterstics of Rosuvastatin in Chinese Volunteers]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 46, no. 6, 2011, pp. 695-700.
Sui SM, Wen JH, Li XH, et al. [Effect of OATP1B1 521T --> C heterogenesis on pharmacokinetic characterstics of rosuvastatin in Chinese volunteers]. Yao Xue Xue Bao. 2011;46(6):695-700.
Sui, S. M., Wen, J. H., Li, X. H., & Xiong, Y. Q. (2011). [Effect of OATP1B1 521T --> C heterogenesis on pharmacokinetic characterstics of rosuvastatin in Chinese volunteers]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 46(6), 695-700.
Sui SM, et al. [Effect of OATP1B1 521T --> C Heterogenesis On Pharmacokinetic Characterstics of Rosuvastatin in Chinese Volunteers]. Yao Xue Xue Bao. 2011;46(6):695-700. PubMed PMID: 21882531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of OATP1B1 521T --> C heterogenesis on pharmacokinetic characterstics of rosuvastatin in Chinese volunteers]. AU - Sui,Shuang-Ming, AU - Wen,Jin-Hua, AU - Li,Xin-Hua, AU - Xiong,Yu-Qing, PY - 2011/9/3/entrez PY - 2011/9/3/pubmed PY - 2013/2/26/medline SP - 695 EP - 700 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 46 IS - 6 N2 - This study is to report the effect of OATP1B1 gene mutation in the 521T --> C in Chinese human on the pharmacokinetics of rosuvastatin and guide the reasonable clinical application of rosuvastatin by the feature of genetic polymorphism of OATP1B1. Plasma samples were determined with LC-MS: the analyte and internal standard pitavastatin were both analyzed by MS in the ESI, m/z was 480.0 for rosuvastatin and 420.0 for the IS, separately. Genotyping of OATP1B1 was determined with the method of polymerase chain reaction--amplification refractory mutation system targeted at 40 healthy volunteers and showed that there were 7 subjects with 521T --> C mutant, accounting to 17.5% of total and wild type homozygote accounted to 82.5%. It was found that there were significant differences between OATP1B1 mutation in the 521T --> C and wild type homozygote for rosuvastatin pharmacokinetic process in Chinese human. In contrast to OATP1B1 wild type group, OATP1B1 mutation group's absorption degree increased, elimination process decreased. The OATP1B1 mutation should be noted for guiding the reasonable application of rosuvastatin during its clinical use. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/21882531/[Effect_of_OATP1B1_521T___>_C_heterogenesis_on_pharmacokinetic_characterstics_of_rosuvastatin_in_Chinese_volunteers]_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -