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Inhibition of marine biofouling by bacterial quorum sensing inhibitors.
Biofouling. 2011 Sep; 27(8):893-905.B

Abstract

Seventy eight natural products from chemical libraries containing compounds from marine organisms (sponges, algae, fungi, tunicates and cyanobacteria) and terrestrial plants, were screened for the inhibition of bacterial quorum sensing (QS) using a reporter strain Chromobacterium violaceum CV017. About half of the natural products did not show any QS inhibition. Twenty four percent of the tested compounds inhibited QS of the reporter without causing toxicity. The QS inhibitory activities of the most potent and abundant compounds were further investigated using the LuxR-based reporter E. coli pSB401 and the LasR-based reporter E. coli pSB1075. Midpacamide and tenuazonic acid were toxic to the tested reporters. QS-dependent luminescence of the LasR-based reporter, which is normally induced by N-3-oxo-dodecanoyl-L-homoserine lactone, was reduced by demethoxy encecalin and hymenialdisin at concentrations >6.6 μM and 15 μM, respectively. Hymenialdisin, demethoxy encecalin, microcolins A and B and kojic acid inhibited responses of the LuxR-based reporter induced by N-3-oxo-hexanoyl-L-homoserine lactone at concentrations >0.2 μM, 2.2 μM, 1.5 μM, 15 μM and 36 μM, respectively. The ability to prevent microfouling by one of the compounds screened in this study (kojic acid; final concentrations 330 μM and 1 mM) was tested in a controlled mesocosm experiment. Kojic acid inhibited formation of microbial communities on glass slides, decreasing the densities of bacteria and diatoms in comparison with the control lacking kojic acid. The study suggests that natural products with QS inhibitory properties can be used for controlling biofouling communities.

Authors+Show Affiliations

Department of Marine Science and Fisheries, College of Agricultural and Marine Sciences, Sultan Qaboos University, Sultanate of Oman. sergey@squ.edu.omNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21882898

Citation

Dobretsov, Sergey, et al. "Inhibition of Marine Biofouling By Bacterial Quorum Sensing Inhibitors." Biofouling, vol. 27, no. 8, 2011, pp. 893-905.
Dobretsov S, Teplitski M, Bayer M, et al. Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Biofouling. 2011;27(8):893-905.
Dobretsov, S., Teplitski, M., Bayer, M., Gunasekera, S., Proksch, P., & Paul, V. J. (2011). Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Biofouling, 27(8), 893-905. https://doi.org/10.1080/08927014.2011.609616
Dobretsov S, et al. Inhibition of Marine Biofouling By Bacterial Quorum Sensing Inhibitors. Biofouling. 2011;27(8):893-905. PubMed PMID: 21882898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of marine biofouling by bacterial quorum sensing inhibitors. AU - Dobretsov,Sergey, AU - Teplitski,Max, AU - Bayer,Mirko, AU - Gunasekera,Sarath, AU - Proksch,Peter, AU - Paul,Valerie J, PY - 2011/9/3/entrez PY - 2011/9/3/pubmed PY - 2012/1/4/medline SP - 893 EP - 905 JF - Biofouling JO - Biofouling VL - 27 IS - 8 N2 - Seventy eight natural products from chemical libraries containing compounds from marine organisms (sponges, algae, fungi, tunicates and cyanobacteria) and terrestrial plants, were screened for the inhibition of bacterial quorum sensing (QS) using a reporter strain Chromobacterium violaceum CV017. About half of the natural products did not show any QS inhibition. Twenty four percent of the tested compounds inhibited QS of the reporter without causing toxicity. The QS inhibitory activities of the most potent and abundant compounds were further investigated using the LuxR-based reporter E. coli pSB401 and the LasR-based reporter E. coli pSB1075. Midpacamide and tenuazonic acid were toxic to the tested reporters. QS-dependent luminescence of the LasR-based reporter, which is normally induced by N-3-oxo-dodecanoyl-L-homoserine lactone, was reduced by demethoxy encecalin and hymenialdisin at concentrations >6.6 μM and 15 μM, respectively. Hymenialdisin, demethoxy encecalin, microcolins A and B and kojic acid inhibited responses of the LuxR-based reporter induced by N-3-oxo-hexanoyl-L-homoserine lactone at concentrations >0.2 μM, 2.2 μM, 1.5 μM, 15 μM and 36 μM, respectively. The ability to prevent microfouling by one of the compounds screened in this study (kojic acid; final concentrations 330 μM and 1 mM) was tested in a controlled mesocosm experiment. Kojic acid inhibited formation of microbial communities on glass slides, decreasing the densities of bacteria and diatoms in comparison with the control lacking kojic acid. The study suggests that natural products with QS inhibitory properties can be used for controlling biofouling communities. SN - 1029-2454 UR - https://www.unboundmedicine.com/medline/citation/21882898/abstract/Inhibition_of_marine_biofouling_by_bacterial_quorum_sensing_inhibitors_ L2 - https://www.tandfonline.com/doi/full/10.1080/08927014.2011.609616 DB - PRIME DP - Unbound Medicine ER -