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Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation.
Dev Med Child Neurol. 2011 Dec; 53(12):1143-9.DM

Abstract

AIM

Vagus nerve stimulation (VNS) is a therapeutic option for individuals with refractory epilepsy. Individuals with refractory epilepsy are prone to dysfunction of the autonomic nervous system. Reduced heart rate variability is a marker of dysfunction of the autonomic nervous system. Our goal was to study heart rate variability in children with refractory epilepsy and the influence of VNS on this parameter.

METHODS

In 17 children (13 male; four female; mean age 7 y 6 mo; age range 3-16 y) with refractory epilepsy, electroencephalographic and electrocardiographic data were obtained before and after implantation of VNS during stage 2 and slow-wave sleep. Time and frequency domain parameters were calculated and the results were compared with an age- and sex-matched group of individuals without refractory epilepsy.

RESULTS

Our results show that autonomic cardiac control is affected in individuals with refractory epilepsy. There is a striking reduction in vagal tone during slow-wave sleep and modulation capacity is smaller than in individuals without refractory epilepsy. Implantation of VNS induces a shift in sympathovagal balance towards sympathetic predominance and an improvement in autonomic modulation.

INTERPRETATION

Heart rate variability is affected in children with refractory epilepsy, and changes after implantation of VNS. The observed changes could be of importance in the cardiac complications of individuals with epilepsy and should be explored in more detail.

Authors+Show Affiliations

Department of Pediatric Neurology, University Hospitals Leuven, Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21883174

Citation

Jansen, Katrien, et al. "Autonomic Effects of Refractory Epilepsy On Heart Rate Variability in Children: Influence of Intermittent Vagus Nerve Stimulation." Developmental Medicine and Child Neurology, vol. 53, no. 12, 2011, pp. 1143-9.
Jansen K, Vandeput S, Milosevic M, et al. Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation. Dev Med Child Neurol. 2011;53(12):1143-9.
Jansen, K., Vandeput, S., Milosevic, M., Ceulemans, B., Van Huffel, S., Brown, L., Penders, J., & Lagae, L. (2011). Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation. Developmental Medicine and Child Neurology, 53(12), 1143-9. https://doi.org/10.1111/j.1469-8749.2011.04103.x
Jansen K, et al. Autonomic Effects of Refractory Epilepsy On Heart Rate Variability in Children: Influence of Intermittent Vagus Nerve Stimulation. Dev Med Child Neurol. 2011;53(12):1143-9. PubMed PMID: 21883174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation. AU - Jansen,Katrien, AU - Vandeput,Steven, AU - Milosevic,Milica, AU - Ceulemans,Berten, AU - Van Huffel,Sabine, AU - Brown,Lindsay, AU - Penders,Julien, AU - Lagae,Lieven, Y1 - 2011/08/31/ PY - 2011/9/3/entrez PY - 2011/9/3/pubmed PY - 2012/1/6/medline SP - 1143 EP - 9 JF - Developmental medicine and child neurology JO - Dev Med Child Neurol VL - 53 IS - 12 N2 - AIM: Vagus nerve stimulation (VNS) is a therapeutic option for individuals with refractory epilepsy. Individuals with refractory epilepsy are prone to dysfunction of the autonomic nervous system. Reduced heart rate variability is a marker of dysfunction of the autonomic nervous system. Our goal was to study heart rate variability in children with refractory epilepsy and the influence of VNS on this parameter. METHODS: In 17 children (13 male; four female; mean age 7 y 6 mo; age range 3-16 y) with refractory epilepsy, electroencephalographic and electrocardiographic data were obtained before and after implantation of VNS during stage 2 and slow-wave sleep. Time and frequency domain parameters were calculated and the results were compared with an age- and sex-matched group of individuals without refractory epilepsy. RESULTS: Our results show that autonomic cardiac control is affected in individuals with refractory epilepsy. There is a striking reduction in vagal tone during slow-wave sleep and modulation capacity is smaller than in individuals without refractory epilepsy. Implantation of VNS induces a shift in sympathovagal balance towards sympathetic predominance and an improvement in autonomic modulation. INTERPRETATION: Heart rate variability is affected in children with refractory epilepsy, and changes after implantation of VNS. The observed changes could be of importance in the cardiac complications of individuals with epilepsy and should be explored in more detail. SN - 1469-8749 UR - https://www.unboundmedicine.com/medline/citation/21883174/Autonomic_effects_of_refractory_epilepsy_on_heart_rate_variability_in_children:_influence_of_intermittent_vagus_nerve_stimulation_ L2 - https://doi.org/10.1111/j.1469-8749.2011.04103.x DB - PRIME DP - Unbound Medicine ER -