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Impaired fasting glucose, ancestry and waist-to-height ratio: main predictors of incident diagnosed diabetes in the Canary Islands.
Diabet Med. 2012 Mar; 29(3):399-403.DM

Abstract

AIMS

To estimate the incidence rate and risk factors for diabetes in the Canary Islands.

METHODS

A total of 5521 adults without diabetes were followed for a median of 3.5 years. Incident cases of diabetes were self-declared and validated in medical records. The following factors were assessed by Cox regression to estimate the hazard ratios for diabetes: impaired fasting glucose (5.6 mmol/l ≤ fasting glucose ≤ 6.9 mmol/l), BMI, waist-to-height ratio (≥ 0.55), insulin resistance (defined as triglycerides/HDL cholesterol ≥ 3), familial antecedents of diabetes, Canarian ancestry, smoking, alcohol intake, sedentary lifestyle, Mediterranean diet, social class and the metabolic syndrome.

RESULTS

The incidence rate was 7.5/10(3) person-years (95% CI 6.4-8.8). The greatest risks were obtained for impaired fasting glucose (hazard ratio 2.6; 95% CI 1.8-3.8), Canarian ancestry (hazard ratio 1.9; 95% CI 1.0-3.4), waist-to-height ratio (hazard ratio 1.7; 95% CI 1.1-2.5), insulin resistance (hazard ratio 1.5; 95% CI 1.0-2.2) and paternal history of diabetes (hazard ratio 1.5; 95% CI 1.0-2.3). The metabolic syndrome (hazard ratio 1.9; 95% CI 1.3-2.8) and BMI ≥ 30 kg/m(2) (hazard ratio 1.7; 95% CI 1.0-2.7) were significant only when their effects were not adjusted for impaired fasting glucose and waist-to-height ratio, respectively.

CONCLUSIONS

The incidence of diabetes in the Canary Islands is 1.5-fold higher than that in continental Spain and 1.7-fold higher than in the UK. The main predictors of diabetes were impaired fasting glucose, Canarian ancestry, waist-to-height ratio and insulin resistance. The metabolic syndrome predicted diabetes only when its effect was not adjusted for impaired fasting glucose. In individuals with Canarian ancestry, genetic susceptibility studies may be advisable. In order to propose preventive strategies, impaired fasting glucose, waist-to-height ratio and triglyceride/HDL cholesterol should be used to identify subjects with an increased risk of developing diabetes.

Authors+Show Affiliations

Primary Care Research Unit and Nuestra Señora de la Candelaria University Hospital, Tenerife, Canary Islands, Spain. acableo@gobiernodecanarias.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21883429

Citation

de León, A Cabrera, et al. "Impaired Fasting Glucose, Ancestry and Waist-to-height Ratio: Main Predictors of Incident Diagnosed Diabetes in the Canary Islands." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 29, no. 3, 2012, pp. 399-403.
de León AC, Coello SD, González DA, et al. Impaired fasting glucose, ancestry and waist-to-height ratio: main predictors of incident diagnosed diabetes in the Canary Islands. Diabet Med. 2012;29(3):399-403.
de León, A. C., Coello, S. D., González, D. A., Díaz, B. B., Rodríguez, J. C., Hernández, A. G., Aguirre-Jaime, A., & Pérez, M. d. e. l. . C. (2012). Impaired fasting glucose, ancestry and waist-to-height ratio: main predictors of incident diagnosed diabetes in the Canary Islands. Diabetic Medicine : a Journal of the British Diabetic Association, 29(3), 399-403. https://doi.org/10.1111/j.1464-5491.2011.03420.x
de León AC, et al. Impaired Fasting Glucose, Ancestry and Waist-to-height Ratio: Main Predictors of Incident Diagnosed Diabetes in the Canary Islands. Diabet Med. 2012;29(3):399-403. PubMed PMID: 21883429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired fasting glucose, ancestry and waist-to-height ratio: main predictors of incident diagnosed diabetes in the Canary Islands. AU - de León,A Cabrera, AU - Coello,S Domínguez, AU - González,D Almeida, AU - Díaz,B Brito, AU - Rodríguez,J C del Castillo, AU - Hernández,A González, AU - Aguirre-Jaime,A, AU - Pérez,M del Cristo Rodríguez, PY - 2011/9/3/entrez PY - 2011/9/3/pubmed PY - 2012/7/17/medline SP - 399 EP - 403 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 29 IS - 3 N2 - AIMS: To estimate the incidence rate and risk factors for diabetes in the Canary Islands. METHODS: A total of 5521 adults without diabetes were followed for a median of 3.5 years. Incident cases of diabetes were self-declared and validated in medical records. The following factors were assessed by Cox regression to estimate the hazard ratios for diabetes: impaired fasting glucose (5.6 mmol/l ≤ fasting glucose ≤ 6.9 mmol/l), BMI, waist-to-height ratio (≥ 0.55), insulin resistance (defined as triglycerides/HDL cholesterol ≥ 3), familial antecedents of diabetes, Canarian ancestry, smoking, alcohol intake, sedentary lifestyle, Mediterranean diet, social class and the metabolic syndrome. RESULTS: The incidence rate was 7.5/10(3) person-years (95% CI 6.4-8.8). The greatest risks were obtained for impaired fasting glucose (hazard ratio 2.6; 95% CI 1.8-3.8), Canarian ancestry (hazard ratio 1.9; 95% CI 1.0-3.4), waist-to-height ratio (hazard ratio 1.7; 95% CI 1.1-2.5), insulin resistance (hazard ratio 1.5; 95% CI 1.0-2.2) and paternal history of diabetes (hazard ratio 1.5; 95% CI 1.0-2.3). The metabolic syndrome (hazard ratio 1.9; 95% CI 1.3-2.8) and BMI ≥ 30 kg/m(2) (hazard ratio 1.7; 95% CI 1.0-2.7) were significant only when their effects were not adjusted for impaired fasting glucose and waist-to-height ratio, respectively. CONCLUSIONS: The incidence of diabetes in the Canary Islands is 1.5-fold higher than that in continental Spain and 1.7-fold higher than in the UK. The main predictors of diabetes were impaired fasting glucose, Canarian ancestry, waist-to-height ratio and insulin resistance. The metabolic syndrome predicted diabetes only when its effect was not adjusted for impaired fasting glucose. In individuals with Canarian ancestry, genetic susceptibility studies may be advisable. In order to propose preventive strategies, impaired fasting glucose, waist-to-height ratio and triglyceride/HDL cholesterol should be used to identify subjects with an increased risk of developing diabetes. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/21883429/Impaired_fasting_glucose_ancestry_and_waist_to_height_ratio:_main_predictors_of_incident_diagnosed_diabetes_in_the_Canary_Islands_ L2 - https://doi.org/10.1111/j.1464-5491.2011.03420.x DB - PRIME DP - Unbound Medicine ER -