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Impact of histology on prognosis of patients with early-stage cervical cancer treated with radical surgery.
Int J Gynaecol Obstet. 2011 Nov; 115(2):183-7.IJ

Abstract

OBJECTIVE

To examine the effect of carcinoma cell type on tumor characteristics, tumor spread, tumor recurrence, and survival of patients with early-stage cervical cancer who had radical hysterectomy and pelvic lymphadenectomy.

METHOD

Data from 499 patients with stage IA to IIA cervical carcinoma who received primary surgical treatment from 2003 to 2005 at Chiang Mai University were retrospectively reviewed with regard to 3 histologic types; squamous cell carcinoma (SCC), adenocarcinoma (AC), and adenosquamous carcinoma (AS).

RESULTS

Among the 499 patients, 71.1% had SCC, 23.4% had AC, and 5.4% had AS. There was no significant difference in stage, tumor size, tumor characteristics, or rate of loco-regional spread. A higher proportion of women with SCC needed adjuvant radiation (P=0.001). Five-year recurrence-free survival (RFS) and overall survival (OS) were comparable among the groups. Among patients with pelvic node metastasis, 5-year RFS and OS were significantly lower in those with AC than in those with SCC (RFS, 66.1% versus 86.4%, P=0.02; OS, 68.2% versus 88.2%, P=0.05).

CONCLUSION

There was no difference among SCC, AC, and AS in most tumor characteristics, spread, recurrence, and survival in patients with early-stage cervical cancer. Among patients with pelvic lymph node metastasis, AC was associated with less favorable outcomes than SCC.

Authors+Show Affiliations

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21885048

Citation

Rudtanasudjatum, Korapin, et al. "Impact of Histology On Prognosis of Patients With Early-stage Cervical Cancer Treated With Radical Surgery." International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, vol. 115, no. 2, 2011, pp. 183-7.
Rudtanasudjatum K, Charoenkwan K, Khunamornpong S, et al. Impact of histology on prognosis of patients with early-stage cervical cancer treated with radical surgery. Int J Gynaecol Obstet. 2011;115(2):183-7.
Rudtanasudjatum, K., Charoenkwan, K., Khunamornpong, S., & Siriaunkgul, S. (2011). Impact of histology on prognosis of patients with early-stage cervical cancer treated with radical surgery. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 115(2), 183-7. https://doi.org/10.1016/j.ijgo.2011.06.011
Rudtanasudjatum K, et al. Impact of Histology On Prognosis of Patients With Early-stage Cervical Cancer Treated With Radical Surgery. Int J Gynaecol Obstet. 2011;115(2):183-7. PubMed PMID: 21885048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of histology on prognosis of patients with early-stage cervical cancer treated with radical surgery. AU - Rudtanasudjatum,Korapin, AU - Charoenkwan,Kittipat, AU - Khunamornpong,Surapan, AU - Siriaunkgul,Sumalee, Y1 - 2011/08/31/ PY - 2011/02/01/received PY - 2011/06/16/revised PY - 2011/07/28/accepted PY - 2011/9/3/entrez PY - 2011/9/3/pubmed PY - 2012/1/18/medline SP - 183 EP - 7 JF - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JO - Int J Gynaecol Obstet VL - 115 IS - 2 N2 - OBJECTIVE: To examine the effect of carcinoma cell type on tumor characteristics, tumor spread, tumor recurrence, and survival of patients with early-stage cervical cancer who had radical hysterectomy and pelvic lymphadenectomy. METHOD: Data from 499 patients with stage IA to IIA cervical carcinoma who received primary surgical treatment from 2003 to 2005 at Chiang Mai University were retrospectively reviewed with regard to 3 histologic types; squamous cell carcinoma (SCC), adenocarcinoma (AC), and adenosquamous carcinoma (AS). RESULTS: Among the 499 patients, 71.1% had SCC, 23.4% had AC, and 5.4% had AS. There was no significant difference in stage, tumor size, tumor characteristics, or rate of loco-regional spread. A higher proportion of women with SCC needed adjuvant radiation (P=0.001). Five-year recurrence-free survival (RFS) and overall survival (OS) were comparable among the groups. Among patients with pelvic node metastasis, 5-year RFS and OS were significantly lower in those with AC than in those with SCC (RFS, 66.1% versus 86.4%, P=0.02; OS, 68.2% versus 88.2%, P=0.05). CONCLUSION: There was no difference among SCC, AC, and AS in most tumor characteristics, spread, recurrence, and survival in patients with early-stage cervical cancer. Among patients with pelvic lymph node metastasis, AC was associated with less favorable outcomes than SCC. SN - 1879-3479 UR - https://www.unboundmedicine.com/medline/citation/21885048/Impact_of_histology_on_prognosis_of_patients_with_early_stage_cervical_cancer_treated_with_radical_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-7292(11)00372-9 DB - PRIME DP - Unbound Medicine ER -