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Sublingual piroxicam in migraine without aura.
J Assoc Physicians India. 2011 Aug; 59:494-7.JA

Abstract

OBJECTIVE

The aim of the present study was to compare the analgesic efficacy of a single dose of sublingual piroxicam to that of a placebo during acute attacks of migraine without aura.

METHODS

The drug (N = 30) or a placebo (N = 30) was administered, on randomisation and double-blind basis, to 60 patients between 18 and 50 years of age suffering from migraine without aura. The patients were instructed to take a single tablet sublingually [corresponding to piroxicam 40 mg or placebo] and the severity of the painful symptomatology and associated symptoms were evaluated by this study.

RESULTS

The patients treated with sublingual piroxicam showed a significant (P < 0.05) decrease in pain intensity 15 minutes after ingestion; they went on to show a further reduction in the 24 hours after drug administration. On the contrary, the group treated with placebo showed a significant reduction of symptoms only after seven hours of observation. Associated symptoms disappeared significantly (P < 0.05) after sublingual piroxicam administration. In 83.3%, the drug resulted in excellent to good response as compared to only 10% in the placebo group. No local and systemic side effects were reported with sublingual piroxicam.

CONCLUSIONS

The present study has demonstrated that for the acute management of migraine without aura sublingual piroxicam showed significant analgesic effect with excellent tolerability.

Authors+Show Affiliations

'The Headache and Migraine Clinic', Jaslok Hospital and Research Centre, 15, G. Deshmukh Marg, Mumbai 400026, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21887905

Citation

Ravishankar, K, et al. "Sublingual Piroxicam in Migraine Without Aura." The Journal of the Association of Physicians of India, vol. 59, 2011, pp. 494-7.
Ravishankar K, Tayade H, Mandlik R. Sublingual piroxicam in migraine without aura. J Assoc Physicians India. 2011;59:494-7.
Ravishankar, K., Tayade, H., & Mandlik, R. (2011). Sublingual piroxicam in migraine without aura. The Journal of the Association of Physicians of India, 59, 494-7.
Ravishankar K, Tayade H, Mandlik R. Sublingual Piroxicam in Migraine Without Aura. J Assoc Physicians India. 2011;59:494-7. PubMed PMID: 21887905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sublingual piroxicam in migraine without aura. AU - Ravishankar,K, AU - Tayade,Himanshu, AU - Mandlik,Rahul, PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2011/10/1/medline SP - 494 EP - 7 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 59 N2 - OBJECTIVE: The aim of the present study was to compare the analgesic efficacy of a single dose of sublingual piroxicam to that of a placebo during acute attacks of migraine without aura. METHODS: The drug (N = 30) or a placebo (N = 30) was administered, on randomisation and double-blind basis, to 60 patients between 18 and 50 years of age suffering from migraine without aura. The patients were instructed to take a single tablet sublingually [corresponding to piroxicam 40 mg or placebo] and the severity of the painful symptomatology and associated symptoms were evaluated by this study. RESULTS: The patients treated with sublingual piroxicam showed a significant (P < 0.05) decrease in pain intensity 15 minutes after ingestion; they went on to show a further reduction in the 24 hours after drug administration. On the contrary, the group treated with placebo showed a significant reduction of symptoms only after seven hours of observation. Associated symptoms disappeared significantly (P < 0.05) after sublingual piroxicam administration. In 83.3%, the drug resulted in excellent to good response as compared to only 10% in the placebo group. No local and systemic side effects were reported with sublingual piroxicam. CONCLUSIONS: The present study has demonstrated that for the acute management of migraine without aura sublingual piroxicam showed significant analgesic effect with excellent tolerability. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/21887905/Sublingual_piroxicam_in_migraine_without_aura_ L2 - http://www.diseaseinfosearch.org/result/4811 DB - PRIME DP - Unbound Medicine ER -