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Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis.
Appl Physiol Nutr Metab 2011; 36(5):589-97AP

Abstract

Activation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)-mediated transcription is important for both the determination of mitochondrial content and the induction of mitochondrial biogenesis in skeletal muscle. SIRT1 (silent mating type information regulator 2 homolog 1) deactetylation is proposed as a potential activator of PGC-1α transcriptional activity. The current review examines the importance of SIRT1 deacetylation of PGC-1α in skeletal muscle. Models of SIRT1 overexpression and pharmacological activation are examined, but changes in SIRT1 expression and deacetylase activity following acute and chronic contractile activity will be emphasized. In addition, potential mechanisms of SIRT1 activation in skeletal muscle will be examined. The importance of the PGC-1α acetyltransferase GCN5 will also be briefly discussed. The current evidence supports the contribution of SIRT1 deacetylation of PGC-1α to exercise-induced mitochondrial biogenesis. Further research examining exercise-mediated activation of SIRT1 and the role of GCN5 in regulating PGC-1α transcriptional activity in skeletal muscle is required.

Authors+Show Affiliations

School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6, Canada. gurdb@queensu.ca

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21888529

Citation

Gurd, Brendon J.. "Deacetylation of PGC-1α By SIRT1: Importance for Skeletal Muscle Function and Exercise-induced Mitochondrial Biogenesis." Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, vol. 36, no. 5, 2011, pp. 589-97.
Gurd BJ. Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis. Appl Physiol Nutr Metab. 2011;36(5):589-97.
Gurd, B. J. (2011). Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 36(5), pp. 589-97. doi:10.1139/h11-070.
Gurd BJ. Deacetylation of PGC-1α By SIRT1: Importance for Skeletal Muscle Function and Exercise-induced Mitochondrial Biogenesis. Appl Physiol Nutr Metab. 2011;36(5):589-97. PubMed PMID: 21888529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis. A1 - Gurd,Brendon J, Y1 - 2011/09/02/ PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/1/18/medline SP - 589 EP - 97 JF - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JO - Appl Physiol Nutr Metab VL - 36 IS - 5 N2 - Activation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)-mediated transcription is important for both the determination of mitochondrial content and the induction of mitochondrial biogenesis in skeletal muscle. SIRT1 (silent mating type information regulator 2 homolog 1) deactetylation is proposed as a potential activator of PGC-1α transcriptional activity. The current review examines the importance of SIRT1 deacetylation of PGC-1α in skeletal muscle. Models of SIRT1 overexpression and pharmacological activation are examined, but changes in SIRT1 expression and deacetylase activity following acute and chronic contractile activity will be emphasized. In addition, potential mechanisms of SIRT1 activation in skeletal muscle will be examined. The importance of the PGC-1α acetyltransferase GCN5 will also be briefly discussed. The current evidence supports the contribution of SIRT1 deacetylation of PGC-1α to exercise-induced mitochondrial biogenesis. Further research examining exercise-mediated activation of SIRT1 and the role of GCN5 in regulating PGC-1α transcriptional activity in skeletal muscle is required. SN - 1715-5312 UR - https://www.unboundmedicine.com/medline/citation/21888529/Deacetylation_of_PGC_1α_by_SIRT1:_importance_for_skeletal_muscle_function_and_exercise_induced_mitochondrial_biogenesis_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/h11-070?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -