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Feasibility and antihypertensive effect of replacing regular salt with mineral salt -rich in magnesium and potassium- in subjects with mildly elevated blood pressure.
Nutr J. 2011 Sep 02; 10:88.NJ

Abstract

BACKGROUND

High salt intake is linked to hypertension whereas a restriction of dietary salt lowers blood pressure (BP). Substituting potassium and/or magnesium salts for sodium chloride (NaCl) may enhance the feasibility of salt restriction and lower blood pressure beyond the sodium reduction alone. The aim of this study was to determine the feasibility and effect on blood pressure of replacing NaCl (Regular salt) with a novel mineral salt [50% sodium chloride and rich in potassium chloride (25%), magnesium ammonium potassium chloride, hydrate (25%)] (Smart Salt).

METHODS

A randomized, double-blind, placebo-controlled study was conducted with an intervention period of 8-weeks in subjects (n = 45) with systolic (S)BP 130-159 mmHg and/or diastolic (D)BP 85-99 mmHg. During the intervention period, subjects consumed processed foods salted with either NaCl or Smart Salt. The primary endpoint was the change in SBP. Secondary endpoints were changes in DBP, daily urine excretion of sodium (24-h dU-Na), potassium (dU-K) and magnesium (dU-Mg).

RESULTS

24-h dU-Na decreased significantly in the Smart Salt group (-29.8 mmol; p = 0.012) and remained unchanged in the control group: resulting in a 3.3 g difference in NaCl intake between the groups. Replacement of NaCl with Smart Salt resulted in a significant reduction in SBP over 8 weeks (-7.5 mmHg; p = 0.016). SBP increased (+3.8 mmHg, p = 0.072) slightly in the Regular salt group. The difference in the change of SBP between study groups was significant (p < 0.002).

CONCLUSIONS

The substitution of Smart Salt for Regular salt in subjects with high normal or mildly elevated BP resulted in a significant reduction in their daily sodium intake as well as a reduction in SBP.

Authors+Show Affiliations

Oy Foodfiles Ltd, CRO in the field of nutrition, Neulaniementie 2 L 6, 70210 Kuopio, Finland. essi.sarkkinen@foodfiles.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21888642

Citation

Sarkkinen, Essi S., et al. "Feasibility and Antihypertensive Effect of Replacing Regular Salt With Mineral Salt -rich in Magnesium and Potassium- in Subjects With Mildly Elevated Blood Pressure." Nutrition Journal, vol. 10, 2011, p. 88.
Sarkkinen ES, Kastarinen MJ, Niskanen TH, et al. Feasibility and antihypertensive effect of replacing regular salt with mineral salt -rich in magnesium and potassium- in subjects with mildly elevated blood pressure. Nutr J. 2011;10:88.
Sarkkinen, E. S., Kastarinen, M. J., Niskanen, T. H., Karjalainen, P. H., Venäläinen, T. M., Udani, J. K., & Niskanen, L. K. (2011). Feasibility and antihypertensive effect of replacing regular salt with mineral salt -rich in magnesium and potassium- in subjects with mildly elevated blood pressure. Nutrition Journal, 10, 88. https://doi.org/10.1186/1475-2891-10-88
Sarkkinen ES, et al. Feasibility and Antihypertensive Effect of Replacing Regular Salt With Mineral Salt -rich in Magnesium and Potassium- in Subjects With Mildly Elevated Blood Pressure. Nutr J. 2011 Sep 2;10:88. PubMed PMID: 21888642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Feasibility and antihypertensive effect of replacing regular salt with mineral salt -rich in magnesium and potassium- in subjects with mildly elevated blood pressure. AU - Sarkkinen,Essi S, AU - Kastarinen,Mika J, AU - Niskanen,Tarja H, AU - Karjalainen,Pia H, AU - Venäläinen,Taisa M, AU - Udani,Jay K, AU - Niskanen,Leo K, Y1 - 2011/09/02/ PY - 2011/03/03/received PY - 2011/09/02/accepted PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/1/13/medline SP - 88 EP - 88 JF - Nutrition journal JO - Nutr J VL - 10 N2 - BACKGROUND: High salt intake is linked to hypertension whereas a restriction of dietary salt lowers blood pressure (BP). Substituting potassium and/or magnesium salts for sodium chloride (NaCl) may enhance the feasibility of salt restriction and lower blood pressure beyond the sodium reduction alone. The aim of this study was to determine the feasibility and effect on blood pressure of replacing NaCl (Regular salt) with a novel mineral salt [50% sodium chloride and rich in potassium chloride (25%), magnesium ammonium potassium chloride, hydrate (25%)] (Smart Salt). METHODS: A randomized, double-blind, placebo-controlled study was conducted with an intervention period of 8-weeks in subjects (n = 45) with systolic (S)BP 130-159 mmHg and/or diastolic (D)BP 85-99 mmHg. During the intervention period, subjects consumed processed foods salted with either NaCl or Smart Salt. The primary endpoint was the change in SBP. Secondary endpoints were changes in DBP, daily urine excretion of sodium (24-h dU-Na), potassium (dU-K) and magnesium (dU-Mg). RESULTS: 24-h dU-Na decreased significantly in the Smart Salt group (-29.8 mmol; p = 0.012) and remained unchanged in the control group: resulting in a 3.3 g difference in NaCl intake between the groups. Replacement of NaCl with Smart Salt resulted in a significant reduction in SBP over 8 weeks (-7.5 mmHg; p = 0.016). SBP increased (+3.8 mmHg, p = 0.072) slightly in the Regular salt group. The difference in the change of SBP between study groups was significant (p < 0.002). CONCLUSIONS: The substitution of Smart Salt for Regular salt in subjects with high normal or mildly elevated BP resulted in a significant reduction in their daily sodium intake as well as a reduction in SBP. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/21888642/Feasibility_and_antihypertensive_effect_of_replacing_regular_salt_with_mineral_salt__rich_in_magnesium_and_potassium__in_subjects_with_mildly_elevated_blood_pressure_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-10-88 DB - PRIME DP - Unbound Medicine ER -