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Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea.
Respir Med. 2011 Dec; 105(12):1954-60.RM

Abstract

BACKGROUND

Obstructive sleep apnea (OSA) is related to obesity and metabolic disorders. The main clinical symptoms are excessive daytime sleepiness (EDS) and snoring. However, not all patients with OSA manifest EDS. Hypocretin-1, neuropeptide Y, leptin, ghrelin and adiponectin are implicated in both metabolic and sleep regulation, two conditions affected by OSA. We hypothesized that levels of these peptides may be related to EDS in OSA patients.

METHODS

We included 132 patients with EDS, as defined by an Epworth Sleepiness Scale (ESS) score ≥ 13 (mean ± SD, 15.7 ± 2.3) and 132 patients without EDS as defined by an ESS score ≤ 9 (6.5 ± 1.9). All patients had an apnea-hypopnea index (AHI) ≥ 20 h(-1). Both groups were matched for gender (males; 83.3% vs. 85.6%), age (50.15 ± 11.2 yrs vs. 50.7 ± 9.9 yrs), body mass index (BMI) (31.8 ± 5.6 kg m(-2) vs. 32.1 ± 4.8 kg m(-2)), and apnea-hypopnea index (AHI) (45.5 ± 19.1 h(-1) vs. 43 ± 19.2 h(-1)).

RESULTS

OSA patients with EDS showed significantly higher plasma hypocretin-1 levels (p < 0.001) and lower plasma ghrelin levels (p < 0.001) than OSA patients without EDS. There were no statistically significant differences in neuropeptide Y (p = 0.08), leptin (p = 0.07) and adiponectin (p = 0.72) between the two groups. In the multiple linear regression model ESS score was associated with plasma levels of hypocretin-1, ghrelin and total sleep time.

CONCLUSION

Our study shows that EDS in patients with OSA is associated with increased circulating hypocretin-1 and decreased circulating ghrelin levels, two peptides involved in the regulation of body weight, energy balance, sympathetic tone and sleep-wake cycle. This relationship is independent of AHI and obesity (two key phenotypic features of OSA).

Authors+Show Affiliations

Hospital Universitari Arnau de Vilanova, Respiratory Diseases Research Unit, IRB Lleida, Rovira Roure, 80, 25198 Lleida, Spain. sanchezdelatorre@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21889324

Citation

Sánchez-de-la-Torre, M, et al. "Plasma Levels of Neuropeptides and Metabolic Hormones, and Sleepiness in Obstructive Sleep Apnea." Respiratory Medicine, vol. 105, no. 12, 2011, pp. 1954-60.
Sánchez-de-la-Torre M, Barceló A, Piérola J, et al. Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea. Respir Med. 2011;105(12):1954-60.
Sánchez-de-la-Torre, M., Barceló, A., Piérola, J., Esquinas, C., de la Peña, M., Durán-Cantolla, J., Capote, F., Masa, J. F., Marin, J. M., Vilá, M., Cao, G., Martinez, M., de Lecea, L., Gozal, D., Montserrat, J. M., & Barbé, F. (2011). Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea. Respiratory Medicine, 105(12), 1954-60. https://doi.org/10.1016/j.rmed.2011.08.014
Sánchez-de-la-Torre M, et al. Plasma Levels of Neuropeptides and Metabolic Hormones, and Sleepiness in Obstructive Sleep Apnea. Respir Med. 2011;105(12):1954-60. PubMed PMID: 21889324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea. AU - Sánchez-de-la-Torre,M, AU - Barceló,A, AU - Piérola,J, AU - Esquinas,C, AU - de la Peña,M, AU - Durán-Cantolla,J, AU - Capote,F, AU - Masa,J F, AU - Marin,J M, AU - Vilá,M, AU - Cao,G, AU - Martinez,M, AU - de Lecea,L, AU - Gozal,D, AU - Montserrat,J M, AU - Barbé,F, Y1 - 2011/09/01/ PY - 2011/02/17/received PY - 2011/08/11/revised PY - 2011/08/12/accepted PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/1/26/medline SP - 1954 EP - 60 JF - Respiratory medicine JO - Respir Med VL - 105 IS - 12 N2 - BACKGROUND: Obstructive sleep apnea (OSA) is related to obesity and metabolic disorders. The main clinical symptoms are excessive daytime sleepiness (EDS) and snoring. However, not all patients with OSA manifest EDS. Hypocretin-1, neuropeptide Y, leptin, ghrelin and adiponectin are implicated in both metabolic and sleep regulation, two conditions affected by OSA. We hypothesized that levels of these peptides may be related to EDS in OSA patients. METHODS: We included 132 patients with EDS, as defined by an Epworth Sleepiness Scale (ESS) score ≥ 13 (mean ± SD, 15.7 ± 2.3) and 132 patients without EDS as defined by an ESS score ≤ 9 (6.5 ± 1.9). All patients had an apnea-hypopnea index (AHI) ≥ 20 h(-1). Both groups were matched for gender (males; 83.3% vs. 85.6%), age (50.15 ± 11.2 yrs vs. 50.7 ± 9.9 yrs), body mass index (BMI) (31.8 ± 5.6 kg m(-2) vs. 32.1 ± 4.8 kg m(-2)), and apnea-hypopnea index (AHI) (45.5 ± 19.1 h(-1) vs. 43 ± 19.2 h(-1)). RESULTS: OSA patients with EDS showed significantly higher plasma hypocretin-1 levels (p < 0.001) and lower plasma ghrelin levels (p < 0.001) than OSA patients without EDS. There were no statistically significant differences in neuropeptide Y (p = 0.08), leptin (p = 0.07) and adiponectin (p = 0.72) between the two groups. In the multiple linear regression model ESS score was associated with plasma levels of hypocretin-1, ghrelin and total sleep time. CONCLUSION: Our study shows that EDS in patients with OSA is associated with increased circulating hypocretin-1 and decreased circulating ghrelin levels, two peptides involved in the regulation of body weight, energy balance, sympathetic tone and sleep-wake cycle. This relationship is independent of AHI and obesity (two key phenotypic features of OSA). SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/21889324/Plasma_levels_of_neuropeptides_and_metabolic_hormones_and_sleepiness_in_obstructive_sleep_apnea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(11)00291-5 DB - PRIME DP - Unbound Medicine ER -