Tags

Type your tag names separated by a space and hit enter

Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD.
J Nutr Biochem. 2012 Jul; 23(7):817-21.JN

Abstract

Dietary intake of polyunsaturated fatty acids, including omega-3 and omega-6, could modulate chronic obstructive pulmonary disease (COPD) persistent inflammation. We aimed to assess the relationship between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD. A total of 250 clinically stable COPD patients were included. Dietary data of the last 2 years were assessed using a validated food frequency questionnaire (122 items), which provided levels of three omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and α-linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and arachidonic acid (AA). Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNFα)] were measured in serum. Fatty acids and inflammatory markers were dichotomised according to their median values, and their association was assessed using multivariate logistic regression. Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was associated with lower TNFα concentrations [adjusted odds ratio (OR)=0.46; P=.049]. Higher AA intake (a proinflammatory omega-6 fatty acid) was related to higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039) concentrations. Therefore, this study provides the first evidence of an association between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD patients.

Authors+Show Affiliations

Centre for Research in Environmental Epidemiology-CREAL, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21889886

Citation

de Batlle, Jordi, et al. "Association Between Ω3 and Ω6 Fatty Acid Intakes and Serum Inflammatory Markers in COPD." The Journal of Nutritional Biochemistry, vol. 23, no. 7, 2012, pp. 817-21.
de Batlle J, Sauleda J, Balcells E, et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. J Nutr Biochem. 2012;23(7):817-21.
de Batlle, J., Sauleda, J., Balcells, E., Gómez, F. P., Méndez, M., Rodriguez, E., Barreiro, E., Ferrer, J. J., Romieu, I., Gea, J., Antó, J. M., & Garcia-Aymerich, J. (2012). Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. The Journal of Nutritional Biochemistry, 23(7), 817-21. https://doi.org/10.1016/j.jnutbio.2011.04.005
de Batlle J, et al. Association Between Ω3 and Ω6 Fatty Acid Intakes and Serum Inflammatory Markers in COPD. J Nutr Biochem. 2012;23(7):817-21. PubMed PMID: 21889886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. AU - de Batlle,Jordi, AU - Sauleda,Jaume, AU - Balcells,Eva, AU - Gómez,Federico P, AU - Méndez,Michelle, AU - Rodriguez,Esther, AU - Barreiro,Esther, AU - Ferrer,Jaume J, AU - Romieu,Isabelle, AU - Gea,Joaquim, AU - Antó,Josep M, AU - Garcia-Aymerich,Judith, AU - ,, Y1 - 2011/09/01/ PY - 2010/10/14/received PY - 2011/04/04/revised PY - 2011/04/08/accepted PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/11/3/medline SP - 817 EP - 21 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 23 IS - 7 N2 - Dietary intake of polyunsaturated fatty acids, including omega-3 and omega-6, could modulate chronic obstructive pulmonary disease (COPD) persistent inflammation. We aimed to assess the relationship between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD. A total of 250 clinically stable COPD patients were included. Dietary data of the last 2 years were assessed using a validated food frequency questionnaire (122 items), which provided levels of three omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and α-linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and arachidonic acid (AA). Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNFα)] were measured in serum. Fatty acids and inflammatory markers were dichotomised according to their median values, and their association was assessed using multivariate logistic regression. Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was associated with lower TNFα concentrations [adjusted odds ratio (OR)=0.46; P=.049]. Higher AA intake (a proinflammatory omega-6 fatty acid) was related to higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039) concentrations. Therefore, this study provides the first evidence of an association between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD patients. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/21889886/Association_between_Ω3_and_Ω6_fatty_acid_intakes_and_serum_inflammatory_markers_in_COPD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(11)00132-X DB - PRIME DP - Unbound Medicine ER -