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History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability.
J Psychopharmacol 2012; 26(1):144-9JP

Abstract

Cannabis use in adolescence is emerging as a risk factor for the development of psychosis. In animal studies, Δ9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, modulates striatal dopaminergic neurotransmission. Alterations in human striatal dopaminergic function have also been reported both in psychosis and in stimulant use. We sought to examine whether striatal dopamine D(2)/D(3) receptor availability was altered in volunteers with a history of cannabis use using a database of previously acquired [(11)C]-raclopride positron emission tomography (PET) scans. Ten [(11)C]-raclopride scans from volunteers with a history of cannabis use were compared to ten control scans using a functional striatal subdivision region of interest (ROI) analysis. No significant differences in either overall striatal BP(ND) values or BP(ND) values in any functional striatal subdivision were found between the two groups. There was also no correlation between lifetime frequency of cannabis use and BP(ND) values. Limbic striatal BP(ND) values were ten percent lower in current nicotine cigarette smokers. These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability.

Authors+Show Affiliations

Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK. paul.stokes@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21890594

Citation

Stokes, Paul R A., et al. "History of Cannabis Use Is Not Associated With Alterations in Striatal Dopamine D2/D3 Receptor Availability." Journal of Psychopharmacology (Oxford, England), vol. 26, no. 1, 2012, pp. 144-9.
Stokes PR, Egerton A, Watson B, et al. History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability. J Psychopharmacol (Oxford). 2012;26(1):144-9.
Stokes, P. R., Egerton, A., Watson, B., Reid, A., Lappin, J., Howes, O. D., ... Lingford-Hughes, A. R. (2012). History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability. Journal of Psychopharmacology (Oxford, England), 26(1), pp. 144-9. doi:10.1177/0269881111414090.
Stokes PR, et al. History of Cannabis Use Is Not Associated With Alterations in Striatal Dopamine D2/D3 Receptor Availability. J Psychopharmacol (Oxford). 2012;26(1):144-9. PubMed PMID: 21890594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability. AU - Stokes,Paul R A, AU - Egerton,Alice, AU - Watson,Ben, AU - Reid,Alistair, AU - Lappin,Julia, AU - Howes,Oliver D, AU - Nutt,David J, AU - Lingford-Hughes,Anne R, Y1 - 2011/09/02/ PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/8/22/medline SP - 144 EP - 9 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 26 IS - 1 N2 - Cannabis use in adolescence is emerging as a risk factor for the development of psychosis. In animal studies, Δ9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, modulates striatal dopaminergic neurotransmission. Alterations in human striatal dopaminergic function have also been reported both in psychosis and in stimulant use. We sought to examine whether striatal dopamine D(2)/D(3) receptor availability was altered in volunteers with a history of cannabis use using a database of previously acquired [(11)C]-raclopride positron emission tomography (PET) scans. Ten [(11)C]-raclopride scans from volunteers with a history of cannabis use were compared to ten control scans using a functional striatal subdivision region of interest (ROI) analysis. No significant differences in either overall striatal BP(ND) values or BP(ND) values in any functional striatal subdivision were found between the two groups. There was also no correlation between lifetime frequency of cannabis use and BP(ND) values. Limbic striatal BP(ND) values were ten percent lower in current nicotine cigarette smokers. These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/21890594/abstract/History_of_cannabis_use_is_not_associated_with_alterations_in_striatal_dopamine_D2/D3_receptor_availability_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881111414090?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -