Tags

Type your tag names separated by a space and hit enter

Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study.
J Alzheimers Dis 2011; 27(4):909-22JA

Abstract

There is some debate regarding the differing levels of plasma homocysteine, vitamin B12 and serum folate between healthy controls (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). As part of the Australian Imaging Biomarker Lifestyle (AIBL) study of aging cohort, consisting of 1,112 participants (768 HC, 133 MCI patients, and 211 AD patients), plasma homocysteine, vitamin B12, and serum and red cell folate were measured at baseline to investigate their levels, their inter-associations, and their relationships with cognition. The results of this cross-sectional study showed that homocysteine levels were increased in female AD patients compared to female HC subjects (+16%, p-value < 0.001), but not in males. Red cell folate, but not serum folate, was decreased in AD patients compared to HC (-10%, p-value = 0.004). Composite z-scores of short- and long-term episodic memory, total episodic memory, and global cognition all showed significant negative correlations with homocysteine, in all clinical categories. Increasing red cell folate had a U-shaped association with homocysteine, so that high red cell folate levels were associated with worse long-term episodic memory, total episodic memory, and global cognition. These findings underscore the association of plasma homocysteine with cognitive deterioration, although not unique to AD, and identified an unexpected abnormality of red cell folate.

Authors+Show Affiliations

The Mental Health Research Institute, The University of Melbourne, Parkville, VIC, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21891867

Citation

Faux, Noel G., et al. "Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study." Journal of Alzheimer's Disease : JAD, vol. 27, no. 4, 2011, pp. 909-22.
Faux NG, Ellis KA, Porter L, et al. Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study. J Alzheimers Dis. 2011;27(4):909-22.
Faux, N. G., Ellis, K. A., Porter, L., Fowler, C. J., Laws, S. M., Martins, R. N., ... Bush, A. I. (2011). Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study. Journal of Alzheimer's Disease : JAD, 27(4), pp. 909-22. doi:10.3233/JAD-2011-110752.
Faux NG, et al. Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. J Alzheimers Dis. 2011;27(4):909-22. PubMed PMID: 21891867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study. AU - Faux,Noel G, AU - Ellis,Kathryn A, AU - Porter,Lorine, AU - Fowler,Chris J, AU - Laws,Simon M, AU - Martins,Ralph N, AU - Pertile,Kelly K, AU - Rembach,Alan, AU - Rowe,Chris C, AU - Rumble,Rebecca L, AU - Szoeke,Cassandra, AU - Taddei,Kevin, AU - Taddei,Tania, AU - Trounson,Brett O, AU - Villemagne,Victor L, AU - Ward,Vanessa, AU - Ames,David, AU - Masters,Colin L, AU - Bush,Ashley I, PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/4/17/medline SP - 909 EP - 22 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 27 IS - 4 N2 - There is some debate regarding the differing levels of plasma homocysteine, vitamin B12 and serum folate between healthy controls (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). As part of the Australian Imaging Biomarker Lifestyle (AIBL) study of aging cohort, consisting of 1,112 participants (768 HC, 133 MCI patients, and 211 AD patients), plasma homocysteine, vitamin B12, and serum and red cell folate were measured at baseline to investigate their levels, their inter-associations, and their relationships with cognition. The results of this cross-sectional study showed that homocysteine levels were increased in female AD patients compared to female HC subjects (+16%, p-value < 0.001), but not in males. Red cell folate, but not serum folate, was decreased in AD patients compared to HC (-10%, p-value = 0.004). Composite z-scores of short- and long-term episodic memory, total episodic memory, and global cognition all showed significant negative correlations with homocysteine, in all clinical categories. Increasing red cell folate had a U-shaped association with homocysteine, so that high red cell folate levels were associated with worse long-term episodic memory, total episodic memory, and global cognition. These findings underscore the association of plasma homocysteine with cognitive deterioration, although not unique to AD, and identified an unexpected abnormality of red cell folate. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/21891867/Homocysteine_vitamin_B12_and_folic_acid_levels_in_Alzheimer's_disease_mild_cognitive_impairment_and_healthy_elderly:_baseline_characteristics_in_subjects_of_the_Australian_Imaging_Biomarker_Lifestyle_study_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-2011-110752 DB - PRIME DP - Unbound Medicine ER -