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Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents.
Nutr Hosp. 2011 May-Jun; 26(3):451-7.NH

Abstract

INTRODUCTION

The prevalence of obesity, a serious public health problem, is increasing among teenagers and thus also increases cardiovascular morbidity and mortality in adulthood.

OBJECTIVE

To provide a systematic review of the best evidence about the effect of sibutramine and orlistat in weight loss, quality of life and its adverse effects in adolescents diagnosed with obesity.

METHODS

We searched electronic databases and bibliographies of selected articles were inspected for any further reference. We included only randomized controlled trials that met a set of predefined criteria. The studies were reviewed by a narrative synthesis.

RESULTS

We included 6 randomized controlled trials of sibutramine and 3 of orlistat. The majority reached a moderate to high methodological quality. Sibutramine and orlistat showed a reduction in body mass index (BMI) that was significantly higher compared with the placebo group. We also found a variation of weight with these drugs significantly better than placebo. Only one trial evaluated the quality of life. The incidence of adverse effects was similar for sibutramine and placebo, except for tachycardia. The most common adverse reactions associated with orlistat were gastrointestinal, mild to moderate.

CONCLUSIONS

Sibutramine and orlistat in combination with a hypocaloric diet and changes in lifestyle in obese adolescents achieve a short-term loss of weight greater than that achieved through the dietary-behavioral therapy alone.

Authors+Show Affiliations

Servicio de Endocrinología y Nutrición, Hospital Universitario de Canarias, Tenerife, España. eduardogd@terra.esNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

21892560

Citation

García Díaz, E, and T Martín Folgueras. "Systematic Review of the Clinical Efficacy of Sibutramine and Orlistat in Weigth Loss, Quality of Life and Its Adverse Effects in Obese Adolescents." Nutricion Hospitalaria, vol. 26, no. 3, 2011, pp. 451-7.
García Díaz E, Martín Folgueras T. Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents. Nutr Hosp. 2011;26(3):451-7.
García Díaz, E., & Martín Folgueras, T. (2011). Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents. Nutricion Hospitalaria, 26(3), 451-7. https://doi.org/10.1590/S0212-16112011000300004
García Díaz E, Martín Folgueras T. Systematic Review of the Clinical Efficacy of Sibutramine and Orlistat in Weigth Loss, Quality of Life and Its Adverse Effects in Obese Adolescents. Nutr Hosp. 2011 May-Jun;26(3):451-7. PubMed PMID: 21892560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents. AU - García Díaz,E, AU - Martín Folgueras,T, PY - 2010/11/07/received PY - 2011/03/04/accepted PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/1/10/medline SP - 451 EP - 7 JF - Nutricion hospitalaria JO - Nutr Hosp VL - 26 IS - 3 N2 - INTRODUCTION: The prevalence of obesity, a serious public health problem, is increasing among teenagers and thus also increases cardiovascular morbidity and mortality in adulthood. OBJECTIVE: To provide a systematic review of the best evidence about the effect of sibutramine and orlistat in weight loss, quality of life and its adverse effects in adolescents diagnosed with obesity. METHODS: We searched electronic databases and bibliographies of selected articles were inspected for any further reference. We included only randomized controlled trials that met a set of predefined criteria. The studies were reviewed by a narrative synthesis. RESULTS: We included 6 randomized controlled trials of sibutramine and 3 of orlistat. The majority reached a moderate to high methodological quality. Sibutramine and orlistat showed a reduction in body mass index (BMI) that was significantly higher compared with the placebo group. We also found a variation of weight with these drugs significantly better than placebo. Only one trial evaluated the quality of life. The incidence of adverse effects was similar for sibutramine and placebo, except for tachycardia. The most common adverse reactions associated with orlistat were gastrointestinal, mild to moderate. CONCLUSIONS: Sibutramine and orlistat in combination with a hypocaloric diet and changes in lifestyle in obese adolescents achieve a short-term loss of weight greater than that achieved through the dietary-behavioral therapy alone. SN - 1699-5198 UR - https://www.unboundmedicine.com/medline/citation/21892560/Systematic_review_of_the_clinical_efficacy_of_sibutramine_and_orlistat_in_weigth_loss_quality_of_life_and_its_adverse_effects_in_obese_adolescents_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -