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Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan.
Scand J Infect Dis. 2011 Dec; 43(11-12):937-42.SJ

Abstract

We applied a multiplex polymerase chain reaction (PCR) and culture to detect Streptococcus pneumoniae and detected 3 other respiratory pathogens--Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis--simultaneously by PCR, in the nasopharynx of 386 children aged under 5 y. S. pneumoniae was the most common pathogen carried by children in all age groups, with the rate ranging from 15.8% in children aged 3-4 y to 28.6% in children aged 2-3 y. H. influenzae and M. catarrhalis showed similar carriage rates across all the age groups. Only 2 young children (0.5%) carried A. otitidis. Higher carriage of S. pneumoniae was found in children who had not received the heptavalent pneumococcal conjugate vaccine (PCV7). Cefotaxime non-susceptibility was high (51.4%) in S. pneumoniae nasopharyngeal isolates. Serotype 6B was the most common in fully immunized carriers and also in those who received catch-up immunization. Due to low PCV7 coverage in Taiwan, the carriage of vaccine and non-vaccine serotypes of S. pneumoniae in children remains common.

Authors+Show Affiliations

Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21892897

Citation

Janapatla, Rajendra-Prasad, et al. "Nasopharyngeal Carriage of Streptococcus Pneumoniae, Haemophilus Influenzae, Moraxella Catarrhalis, and Alloiococcus Otitidis in Young Children in the Era of Pneumococcal Immunization, Taiwan." Scandinavian Journal of Infectious Diseases, vol. 43, no. 11-12, 2011, pp. 937-42.
Janapatla RP, Chang HJ, Hsu MH, et al. Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan. Scand J Infect Dis. 2011;43(11-12):937-42.
Janapatla, R. P., Chang, H. J., Hsu, M. H., Hsieh, Y. C., Lin, T. Y., & Chiu, C. H. (2011). Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan. Scandinavian Journal of Infectious Diseases, 43(11-12), 937-42. https://doi.org/10.3109/00365548.2011.601754
Janapatla RP, et al. Nasopharyngeal Carriage of Streptococcus Pneumoniae, Haemophilus Influenzae, Moraxella Catarrhalis, and Alloiococcus Otitidis in Young Children in the Era of Pneumococcal Immunization, Taiwan. Scand J Infect Dis. 2011;43(11-12):937-42. PubMed PMID: 21892897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan. AU - Janapatla,Rajendra-Prasad, AU - Chang,Hsin-Ju, AU - Hsu,Mei-Hua, AU - Hsieh,Yu-Chia, AU - Lin,Tzou-Yien, AU - Chiu,Cheng-Hsun, Y1 - 2011/09/06/ PY - 2011/9/7/entrez PY - 2011/9/7/pubmed PY - 2012/2/22/medline SP - 937 EP - 42 JF - Scandinavian journal of infectious diseases JO - Scand J Infect Dis VL - 43 IS - 11-12 N2 - We applied a multiplex polymerase chain reaction (PCR) and culture to detect Streptococcus pneumoniae and detected 3 other respiratory pathogens--Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis--simultaneously by PCR, in the nasopharynx of 386 children aged under 5 y. S. pneumoniae was the most common pathogen carried by children in all age groups, with the rate ranging from 15.8% in children aged 3-4 y to 28.6% in children aged 2-3 y. H. influenzae and M. catarrhalis showed similar carriage rates across all the age groups. Only 2 young children (0.5%) carried A. otitidis. Higher carriage of S. pneumoniae was found in children who had not received the heptavalent pneumococcal conjugate vaccine (PCV7). Cefotaxime non-susceptibility was high (51.4%) in S. pneumoniae nasopharyngeal isolates. Serotype 6B was the most common in fully immunized carriers and also in those who received catch-up immunization. Due to low PCV7 coverage in Taiwan, the carriage of vaccine and non-vaccine serotypes of S. pneumoniae in children remains common. SN - 1651-1980 UR - https://www.unboundmedicine.com/medline/citation/21892897/Nasopharyngeal_carriage_of_Streptococcus_pneumoniae_Haemophilus_influenzae_Moraxella_catarrhalis_and_Alloiococcus_otitidis_in_young_children_in_the_era_of_pneumococcal_immunization_Taiwan_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365548.2011.601754 DB - PRIME DP - Unbound Medicine ER -