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Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial.
Vaccine 2011; 29(44):7595-8V

Abstract

Seven-valent CRM197-conjugated pneumococcal conjugate vaccine (PCV7(CRM197)) reduces both vaccine serotype nasopharyngeal colonization and vaccine serotype acute otitis media by 50-60%. However, overall pneumococcal carriage and impact on otitis media are partly offset by concomitant increase of nonvaccine serotypes. We investigated in a randomized controlled trial the impact of 2-doses and 2+1-doses of PCV7(CRM197) on carriage of Streptococcus pneumoniae and of other nasopharyngeal commensals and well-known otitis media pathogens, Haemophilus influenzae and Moraxella catarrhalis, in children. Nasopharyngeal swabs were collected at the age of 6 weeks and at 6, 12, 18 and 24 months. We observed high carriage rates up to 68% for S. pneumoniae, 71% for H. influenzae and 68% for M. catarrhalis at the age of 18 months. Reduced dose (CRM197) schedules induced a slight reduction in overall pneumococcal carriage but no increases in the presence of H. influenzae and M. catarrhalis.

Authors+Show Affiliations

Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands. e.j.m.vangils@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21893151

Citation

van Gils, Elske J M., et al. "Effect of 7-valent Pneumococcal Conjugate Vaccine On Nasopharyngeal Carriage With Haemophilus Influenzae and Moraxella Catarrhalis in a Randomized Controlled Trial." Vaccine, vol. 29, no. 44, 2011, pp. 7595-8.
van Gils EJ, Veenhoven RH, Rodenburg GD, et al. Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial. Vaccine. 2011;29(44):7595-8.
van Gils, E. J., Veenhoven, R. H., Rodenburg, G. D., Hak, E., & Sanders, E. A. (2011). Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial. Vaccine, 29(44), pp. 7595-8. doi:10.1016/j.vaccine.2011.08.049.
van Gils EJ, et al. Effect of 7-valent Pneumococcal Conjugate Vaccine On Nasopharyngeal Carriage With Haemophilus Influenzae and Moraxella Catarrhalis in a Randomized Controlled Trial. Vaccine. 2011 Oct 13;29(44):7595-8. PubMed PMID: 21893151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial. AU - van Gils,Elske J M, AU - Veenhoven,Reinier H, AU - Rodenburg,Gerwin D, AU - Hak,Eelko, AU - Sanders,Elisabeth A M, Y1 - 2011/09/03/ PY - 2011/04/30/received PY - 2011/08/01/revised PY - 2011/08/08/accepted PY - 2011/9/7/entrez PY - 2011/9/7/pubmed PY - 2012/1/24/medline SP - 7595 EP - 8 JF - Vaccine JO - Vaccine VL - 29 IS - 44 N2 - Seven-valent CRM197-conjugated pneumococcal conjugate vaccine (PCV7(CRM197)) reduces both vaccine serotype nasopharyngeal colonization and vaccine serotype acute otitis media by 50-60%. However, overall pneumococcal carriage and impact on otitis media are partly offset by concomitant increase of nonvaccine serotypes. We investigated in a randomized controlled trial the impact of 2-doses and 2+1-doses of PCV7(CRM197) on carriage of Streptococcus pneumoniae and of other nasopharyngeal commensals and well-known otitis media pathogens, Haemophilus influenzae and Moraxella catarrhalis, in children. Nasopharyngeal swabs were collected at the age of 6 weeks and at 6, 12, 18 and 24 months. We observed high carriage rates up to 68% for S. pneumoniae, 71% for H. influenzae and 68% for M. catarrhalis at the age of 18 months. Reduced dose (CRM197) schedules induced a slight reduction in overall pneumococcal carriage but no increases in the presence of H. influenzae and M. catarrhalis. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21893151/Effect_of_7_valent_pneumococcal_conjugate_vaccine_on_nasopharyngeal_carriage_with_Haemophilus_influenzae_and_Moraxella_catarrhalis_in_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)01290-4 DB - PRIME DP - Unbound Medicine ER -