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Risk factors for postendoscopic retrograde cholangiopancreatography pancreatitis: a retrospective analysis of 7,168 cases.
Pancreatology 2011; 11(4):399-405P

Abstract

BACKGROUND AND AIMS

Postendoscopic retrograde cholangiopancreatography pancreatitis (PEP) is one of the most common and serious complications after endoscopic retrograde cholangiopancreatography (ERCP). This study aims to test the hypothesis that the incidence of PEP declined over time due to improved patient selection and/or endoscopic equipment and endoscopic techniques. Therefore, we compared the incidence and risk factors of PEP between four arbitrary chronologically stratified groups.

METHODS

A total of 7,168 cases of ERCP procedures were retrospectively analyzed. According to the different developmental stages of ERCP equipment and techniques, cases were divided into four groups. The incidence rates and major risk factors for acute PEP were compared between groups.

RESULTS

Among the 7,168 cases, the overall incidence of PEP was 3.70% (265/7,168). When analyzed against each stage of ERCP development, the incidence of PEP was 4.09% (77/1,884) in stage I, 5.79% (86/1,489) in stage II, 3.95% (62/1,568) in stage III and 1.80% (40/2,227) in stage IV. By univariate analysis, pancreatic stent placement (OR: 0.300) and use of propofol-balanced anesthesia (OR: 0.632) seem to be protective factors for acute PEP. By multivariate analysis, the following risk factors for PEP could be identified: repeated cannulation (OR: 3.462), pancreatic duct injection (OR: 3.218), balloon dilation of biliary sphincter (OR: 2.847), papillae precut (OR: 2.493), nonselective high-pressure injection (OR: 1.428), excessive electrocoagulation incision (OR: 1.263), history of pancreatitis (OR: 3.843) and suspected sphincter of Oddi dysfunction (OR: 1.782).

CONCLUSIONS

Improved technical procedures were associated with a significant reduction in the incidence of PEP. Risks for developing PEP may be minimized by constant improvement in ERCP techniques, such as routine use of a guidewire, highly selective cannulation, pancreatic stent placement and cautious incision.

Authors+Show Affiliations

The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21894057

Citation

Zhou, Wence, et al. "Risk Factors for Postendoscopic Retrograde Cholangiopancreatography Pancreatitis: a Retrospective Analysis of 7,168 Cases." Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], vol. 11, no. 4, 2011, pp. 399-405.
Zhou W, Li Y, Zhang Q, et al. Risk factors for postendoscopic retrograde cholangiopancreatography pancreatitis: a retrospective analysis of 7,168 cases. Pancreatology. 2011;11(4):399-405.
Zhou, W., Li, Y., Zhang, Q., Li, X., Meng, W., Zhang, L., ... Zhu, X. (2011). Risk factors for postendoscopic retrograde cholangiopancreatography pancreatitis: a retrospective analysis of 7,168 cases. Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], 11(4), pp. 399-405. doi:10.1016/S1424-3903(11)80094-3.
Zhou W, et al. Risk Factors for Postendoscopic Retrograde Cholangiopancreatography Pancreatitis: a Retrospective Analysis of 7,168 Cases. Pancreatology. 2011;11(4):399-405. PubMed PMID: 21894057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for postendoscopic retrograde cholangiopancreatography pancreatitis: a retrospective analysis of 7,168 cases. AU - Zhou,Wence, AU - Li,Yumin, AU - Zhang,Quanbao, AU - Li,Xun, AU - Meng,Wenbo, AU - Zhang,Lei, AU - Zhang,Hui, AU - Zhu,Kexiang, AU - Zhu,Xiaoliang, Y1 - 2011/08/31/ PY - 2011/9/7/entrez PY - 2011/9/7/pubmed PY - 2012/2/15/medline SP - 399 EP - 405 JF - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] JO - Pancreatology VL - 11 IS - 4 N2 - BACKGROUND AND AIMS: Postendoscopic retrograde cholangiopancreatography pancreatitis (PEP) is one of the most common and serious complications after endoscopic retrograde cholangiopancreatography (ERCP). This study aims to test the hypothesis that the incidence of PEP declined over time due to improved patient selection and/or endoscopic equipment and endoscopic techniques. Therefore, we compared the incidence and risk factors of PEP between four arbitrary chronologically stratified groups. METHODS: A total of 7,168 cases of ERCP procedures were retrospectively analyzed. According to the different developmental stages of ERCP equipment and techniques, cases were divided into four groups. The incidence rates and major risk factors for acute PEP were compared between groups. RESULTS: Among the 7,168 cases, the overall incidence of PEP was 3.70% (265/7,168). When analyzed against each stage of ERCP development, the incidence of PEP was 4.09% (77/1,884) in stage I, 5.79% (86/1,489) in stage II, 3.95% (62/1,568) in stage III and 1.80% (40/2,227) in stage IV. By univariate analysis, pancreatic stent placement (OR: 0.300) and use of propofol-balanced anesthesia (OR: 0.632) seem to be protective factors for acute PEP. By multivariate analysis, the following risk factors for PEP could be identified: repeated cannulation (OR: 3.462), pancreatic duct injection (OR: 3.218), balloon dilation of biliary sphincter (OR: 2.847), papillae precut (OR: 2.493), nonselective high-pressure injection (OR: 1.428), excessive electrocoagulation incision (OR: 1.263), history of pancreatitis (OR: 3.843) and suspected sphincter of Oddi dysfunction (OR: 1.782). CONCLUSIONS: Improved technical procedures were associated with a significant reduction in the incidence of PEP. Risks for developing PEP may be minimized by constant improvement in ERCP techniques, such as routine use of a guidewire, highly selective cannulation, pancreatic stent placement and cautious incision. SN - 1424-3911 UR - https://www.unboundmedicine.com/medline/citation/21894057/Risk_factors_for_postendoscopic_retrograde_cholangiopancreatography_pancreatitis:_a_retrospective_analysis_of_7168_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1424-3903(11)80094-3 DB - PRIME DP - Unbound Medicine ER -