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[Effect of electroacupuncture on oocyte quality and pregnancy for patients with PCOS undergoing in vitro fertilization and embryo transfervitro fertilization and embryo transfer].
Zhongguo Zhen Jiu. 2011 Aug; 31(8):687-91.ZZ

Abstract

OBJECTIVE

To observe the impacts of electroacupuncture (EA) on oocyte quality and pregnant outcome for the patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET) and explore its potential mechanism.

METHODS

Sixty-six patients with PCOS and undergoing IVF-ET were divided into two groups randomly, including an observation group (34 cases) and a control group (32 cases). Ethinylestradiol and cyproterone acetate tablets and gonadotropin-releasing hormone agonist were administered for long-program superovulation in either group. In observation group, the intervention of EA was applied to Guanyuan (CV 4), Zhongji (CV 3), Sanyinjiao (SP 6), Zigong (EX-CA 1) and Taixi (KI 3) additionally. The pregnant outcome and the levels of stem cell factor (SCF) in the serum and follicular fluid on the day of egg collection were compared between two groups.

RESULTS

The score of kidney deficiency symptoms reduced remarkably after treatment in either group and the improvement in observation group was superior to that in control group (P < 0.01). The fertilization rate [(76.25 +/- 20.33)% vs (66.34 +/- 15.44)%], cleavage rate [(98.66 +/- 3.70)% vs (94.47 +/- 9.45)%] and the rate of high-quality embryos [(60.20 +/- 22.20)% vs (50.55 +/- 16.15)%] in observation group were all superior to those in control group separately (all P < 0.05). Clinical pregnancy rate (46.67%, 14/30) in observation group was higher than that (37.93%, 11/29) in control group, but without statistical difference (P > 0.05). SCF levels in the serum and follicular fluid on the day of ovary collection were higher obviously than those in control group (all P < 0.05).

CONCLUSION

Electroacupuncture plays an active role in the pregnant outcomes of PCOS patients undergoing IVF-ET and it can relieve the symptoms of kidney deficiency in terms of TCM and improve clinical pregnant rate. The results are relevant with the overall adjustment of organic endocrinal system and the local micro-environment of ovary and the improvement of oocyte quality through the up-regulation of SCF level in mechanism.

Authors+Show Affiliations

Cui W
Reproductive Medicine Department, The Second Affiliated Hospital of Shandong University of TCM, Jinan 250001, China. cuiwei9996@sohu.com
Li J
No affiliation info available
Sun W
No affiliation info available
Wen J
No affiliation info available

MeSH

AdultElectroacupunctureEmbryo TransferFemaleFertilization in VitroHumansInfertility, FemaleOocytesOvaryPolycystic Ovary SyndromePregnancyPregnancy RateStem Cell FactorYoung Adult

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21894688

Citation

Cui, Wei, et al. "[Effect of Electroacupuncture On Oocyte Quality and Pregnancy for Patients With PCOS Undergoing in Vitro Fertilization and Embryo Transfervitro Fertilization and Embryo Transfer]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 31, no. 8, 2011, pp. 687-91.
Cui W, Li J, Sun W, et al. [Effect of electroacupuncture on oocyte quality and pregnancy for patients with PCOS undergoing in vitro fertilization and embryo transfervitro fertilization and embryo transfer]. Zhongguo Zhen Jiu. 2011;31(8):687-91.
Cui, W., Li, J., Sun, W., & Wen, J. (2011). [Effect of electroacupuncture on oocyte quality and pregnancy for patients with PCOS undergoing in vitro fertilization and embryo transfervitro fertilization and embryo transfer]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 31(8), 687-91.
Cui W, et al. [Effect of Electroacupuncture On Oocyte Quality and Pregnancy for Patients With PCOS Undergoing in Vitro Fertilization and Embryo Transfervitro Fertilization and Embryo Transfer]. Zhongguo Zhen Jiu. 2011;31(8):687-91. PubMed PMID: 21894688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of electroacupuncture on oocyte quality and pregnancy for patients with PCOS undergoing in vitro fertilization and embryo transfervitro fertilization and embryo transfer]. AU - Cui,Wei, AU - Li,Jing, AU - Sun,Wei, AU - Wen,Ji, PY - 2011/9/8/entrez PY - 2011/9/8/pubmed PY - 2011/9/29/medline SP - 687 EP - 91 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 31 IS - 8 N2 - OBJECTIVE: To observe the impacts of electroacupuncture (EA) on oocyte quality and pregnant outcome for the patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET) and explore its potential mechanism. METHODS: Sixty-six patients with PCOS and undergoing IVF-ET were divided into two groups randomly, including an observation group (34 cases) and a control group (32 cases). Ethinylestradiol and cyproterone acetate tablets and gonadotropin-releasing hormone agonist were administered for long-program superovulation in either group. In observation group, the intervention of EA was applied to Guanyuan (CV 4), Zhongji (CV 3), Sanyinjiao (SP 6), Zigong (EX-CA 1) and Taixi (KI 3) additionally. The pregnant outcome and the levels of stem cell factor (SCF) in the serum and follicular fluid on the day of egg collection were compared between two groups. RESULTS: The score of kidney deficiency symptoms reduced remarkably after treatment in either group and the improvement in observation group was superior to that in control group (P < 0.01). The fertilization rate [(76.25 +/- 20.33)% vs (66.34 +/- 15.44)%], cleavage rate [(98.66 +/- 3.70)% vs (94.47 +/- 9.45)%] and the rate of high-quality embryos [(60.20 +/- 22.20)% vs (50.55 +/- 16.15)%] in observation group were all superior to those in control group separately (all P < 0.05). Clinical pregnancy rate (46.67%, 14/30) in observation group was higher than that (37.93%, 11/29) in control group, but without statistical difference (P > 0.05). SCF levels in the serum and follicular fluid on the day of ovary collection were higher obviously than those in control group (all P < 0.05). CONCLUSION: Electroacupuncture plays an active role in the pregnant outcomes of PCOS patients undergoing IVF-ET and it can relieve the symptoms of kidney deficiency in terms of TCM and improve clinical pregnant rate. The results are relevant with the overall adjustment of organic endocrinal system and the local micro-environment of ovary and the improvement of oocyte quality through the up-regulation of SCF level in mechanism. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/21894688/[Effect_of_electroacupuncture_on_oocyte_quality_and_pregnancy_for_patients_with_PCOS_undergoing_in_vitro_fertilization_and_embryo_transfervitro_fertilization_and_embryo_transfer]_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -