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Ultraviolet-induced red fluorescence of patients with acne reflects regional casual sebum level and acne lesion distribution: qualitative and quantitative analyses of facial fluorescence.

Abstract

BACKGROUND

The ultraviolet (UV)-induced red fluorescence of patients with acne has been considered to be caused by Propionibacterium acnes.

OBJECTIVES

To study the correlation of the facial red fluorescence with the casual sebum level and the number of acne lesions and to investigate the difference in clinical features, according to both distribution and proportion of fluorescence.

METHODS

A total of 878 patients clinically diagnosed with acne vulgaris were included. Inflammatory and noninflammatory acne lesions were counted separately. UV fluorescent photography and casual sebum level measurements were performed. UV-induced fluorescence patterns were classified according to the facial distribution. The proportions of UV-induced red fluorescence were calculated.

RESULTS

We identified six different fluorescence distribution patterns in the T-zone (the forehead, nose and chin) and three different patterns in the U-zone (both cheeks). The proportion of fluorescence in the U-zone showed a positive correlation with the casual sebum level and the number of acne lesions. In the T-zone, the fluorescence proportion correlated with the casual sebum level, but not with the number of acne lesions. As the patients' age and the age at onset increased, the distribution of fluorescence changed from the upper part of the T-zone to the lower part, and to the centre of the face in the U-zone.

CONCLUSIONS

Our results support the hypothesis that the origin of facial red fluorescence is sebum. In patients with acne, analyses of the pattern and proportion of UV-induced red fluorescence can be useful for evaluating the sebum secretion and selecting efficient treatment modalities.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, Seoul National University College of Medicine, and Seoul National University Bundang Hospital, 166 Gumi-10, Seongnam, Gyeonggi 463-707, Korea.

    , ,

    Source

    The British journal of dermatology 166:1 2012 Jan pg 59-66

    MeSH

    Acne Vulgaris
    Adolescent
    Adult
    Age of Onset
    Fluorescence
    Humans
    Photography
    Propionibacterium acnes
    Sebum
    Ultraviolet Rays
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21895623

    Citation

    Choi, C W., et al. "Ultraviolet-induced Red Fluorescence of Patients With Acne Reflects Regional Casual Sebum Level and Acne Lesion Distribution: Qualitative and Quantitative Analyses of Facial Fluorescence." The British Journal of Dermatology, vol. 166, no. 1, 2012, pp. 59-66.
    Choi CW, Choi JW, Park KC, et al. Ultraviolet-induced red fluorescence of patients with acne reflects regional casual sebum level and acne lesion distribution: qualitative and quantitative analyses of facial fluorescence. Br J Dermatol. 2012;166(1):59-66.
    Choi, C. W., Choi, J. W., Park, K. C., & Youn, S. W. (2012). Ultraviolet-induced red fluorescence of patients with acne reflects regional casual sebum level and acne lesion distribution: qualitative and quantitative analyses of facial fluorescence. The British Journal of Dermatology, 166(1), pp. 59-66. doi:10.1111/j.1365-2133.2011.10598.x.
    Choi CW, et al. Ultraviolet-induced Red Fluorescence of Patients With Acne Reflects Regional Casual Sebum Level and Acne Lesion Distribution: Qualitative and Quantitative Analyses of Facial Fluorescence. Br J Dermatol. 2012;166(1):59-66. PubMed PMID: 21895623.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ultraviolet-induced red fluorescence of patients with acne reflects regional casual sebum level and acne lesion distribution: qualitative and quantitative analyses of facial fluorescence. AU - Choi,C W, AU - Choi,J W, AU - Park,K C, AU - Youn,S W, PY - 2011/9/8/entrez PY - 2011/9/8/pubmed PY - 2012/3/17/medline SP - 59 EP - 66 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 166 IS - 1 N2 - BACKGROUND: The ultraviolet (UV)-induced red fluorescence of patients with acne has been considered to be caused by Propionibacterium acnes. OBJECTIVES: To study the correlation of the facial red fluorescence with the casual sebum level and the number of acne lesions and to investigate the difference in clinical features, according to both distribution and proportion of fluorescence. METHODS: A total of 878 patients clinically diagnosed with acne vulgaris were included. Inflammatory and noninflammatory acne lesions were counted separately. UV fluorescent photography and casual sebum level measurements were performed. UV-induced fluorescence patterns were classified according to the facial distribution. The proportions of UV-induced red fluorescence were calculated. RESULTS: We identified six different fluorescence distribution patterns in the T-zone (the forehead, nose and chin) and three different patterns in the U-zone (both cheeks). The proportion of fluorescence in the U-zone showed a positive correlation with the casual sebum level and the number of acne lesions. In the T-zone, the fluorescence proportion correlated with the casual sebum level, but not with the number of acne lesions. As the patients' age and the age at onset increased, the distribution of fluorescence changed from the upper part of the T-zone to the lower part, and to the centre of the face in the U-zone. CONCLUSIONS: Our results support the hypothesis that the origin of facial red fluorescence is sebum. In patients with acne, analyses of the pattern and proportion of UV-induced red fluorescence can be useful for evaluating the sebum secretion and selecting efficient treatment modalities. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/21895623/Ultraviolet_induced_red_fluorescence_of_patients_with_acne_reflects_regional_casual_sebum_level_and_acne_lesion_distribution:_qualitative_and_quantitative_analyses_of_facial_fluorescence_ L2 - https://doi.org/10.1111/j.1365-2133.2011.10598.x DB - PRIME DP - Unbound Medicine ER -