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CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity.
Neurosci Lett. 2011 Oct 10; 503(3):224-8.NL

Abstract

A shared pathology among many neurological and neurodegenerative disorders is neuronal loss. Cannabinoids have been shown to be neuroprotective in multiple systems. However, both agonists and antagonists of the CB(1) cannabinoid receptor are neuroprotective, but the mechanisms responsible for these actions remain unclear. Recently a CB(1) receptor interacting protein, CRIP1a, was identified and found to alter CB(1) activity. Here we show that in an assay of glutamate neurotoxicity in primary neuronal cortical cultures CRIP1a disrupts agonist-induced neuroprotection and confers antagonist-induced neuroprotection.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21896317

Citation

Stauffer, Brandon, et al. "CRIP1a Switches Cannabinoid Receptor Agonist/antagonist-mediated Protection From Glutamate Excitotoxicity." Neuroscience Letters, vol. 503, no. 3, 2011, pp. 224-8.
Stauffer B, Wallis KT, Wilson SP, et al. CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity. Neurosci Lett. 2011;503(3):224-8.
Stauffer, B., Wallis, K. T., Wilson, S. P., Egertová, M., Elphick, M. R., Lewis, D. L., & Hardy, L. R. (2011). CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity. Neuroscience Letters, 503(3), 224-8. https://doi.org/10.1016/j.neulet.2011.08.041
Stauffer B, et al. CRIP1a Switches Cannabinoid Receptor Agonist/antagonist-mediated Protection From Glutamate Excitotoxicity. Neurosci Lett. 2011 Oct 10;503(3):224-8. PubMed PMID: 21896317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity. AU - Stauffer,Brandon, AU - Wallis,Kathleen T, AU - Wilson,Steven P, AU - Egertová,Michaela, AU - Elphick,Maurice R, AU - Lewis,Deborah L, AU - Hardy,Lori Redmond, Y1 - 2011/08/27/ PY - 2011/03/10/received PY - 2011/08/02/revised PY - 2011/08/22/accepted PY - 2011/9/8/entrez PY - 2011/9/8/pubmed PY - 2012/1/21/medline SP - 224 EP - 8 JF - Neuroscience letters JO - Neurosci Lett VL - 503 IS - 3 N2 - A shared pathology among many neurological and neurodegenerative disorders is neuronal loss. Cannabinoids have been shown to be neuroprotective in multiple systems. However, both agonists and antagonists of the CB(1) cannabinoid receptor are neuroprotective, but the mechanisms responsible for these actions remain unclear. Recently a CB(1) receptor interacting protein, CRIP1a, was identified and found to alter CB(1) activity. Here we show that in an assay of glutamate neurotoxicity in primary neuronal cortical cultures CRIP1a disrupts agonist-induced neuroprotection and confers antagonist-induced neuroprotection. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/21896317/CRIP1a_switches_cannabinoid_receptor_agonist/antagonist_mediated_protection_from_glutamate_excitotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(11)01226-2 DB - PRIME DP - Unbound Medicine ER -