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Molecular characterization and complete genome analysis of human enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Thailand during 2008-2011.
Arch Virol. 2011 Nov; 156(11):2007-13.AV

Abstract

Hand, foot and mouth disease (HFMD) has mostly been caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16). CA 16 was the most common cause of HFMD in 2010. EV71 had a high prevalence in 2008-2009 and has been identified with a higher frequency since 2011. Nearly complete genome sequences of three EV71 strains (2008-2009 strains) and two CA16 strains (2010 strains) obtained from outbreaks in Thailand in 2008 to 2010 were characterized. Based on a phylogenetic tree of the complete VP1 region, three EV71 strains grouped into the B5, C1 and C4 genotypes, and two CA16 strains grouped into the C genotype. Based on sequence analysis, nucleotide changes were found to cluster in the internal ribosome entry site (IRES) element of the 5'-untranslated region (5'-UTR). Amino acid differences identified in all strains were located in the non-structural protein. These data also provide the molecular epidemiology of EV71 and CA16 outbreaks in Thailand.

Authors+Show Affiliations

Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21898187

Citation

Puenpa, Jiratchaya, et al. "Molecular Characterization and Complete Genome Analysis of Human Enterovirus 71 and Coxsackievirus A16 From Children With Hand, Foot and Mouth Disease in Thailand During 2008-2011." Archives of Virology, vol. 156, no. 11, 2011, pp. 2007-13.
Puenpa J, Theamboonlers A, Korkong S, et al. Molecular characterization and complete genome analysis of human enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Thailand during 2008-2011. Arch Virol. 2011;156(11):2007-13.
Puenpa, J., Theamboonlers, A., Korkong, S., Linsuwanon, P., Thongmee, C., Chatproedprai, S., & Poovorawan, Y. (2011). Molecular characterization and complete genome analysis of human enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Thailand during 2008-2011. Archives of Virology, 156(11), 2007-13. https://doi.org/10.1007/s00705-011-1098-5
Puenpa J, et al. Molecular Characterization and Complete Genome Analysis of Human Enterovirus 71 and Coxsackievirus A16 From Children With Hand, Foot and Mouth Disease in Thailand During 2008-2011. Arch Virol. 2011;156(11):2007-13. PubMed PMID: 21898187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular characterization and complete genome analysis of human enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Thailand during 2008-2011. AU - Puenpa,Jiratchaya, AU - Theamboonlers,Apiradee, AU - Korkong,Sumeth, AU - Linsuwanon,Piyada, AU - Thongmee,Chittima, AU - Chatproedprai,Susheera, AU - Poovorawan,Yong, Y1 - 2011/09/07/ PY - 2011/07/04/received PY - 2011/08/25/accepted PY - 2011/9/8/entrez PY - 2011/9/8/pubmed PY - 2011/12/30/medline SP - 2007 EP - 13 JF - Archives of virology JO - Arch Virol VL - 156 IS - 11 N2 - Hand, foot and mouth disease (HFMD) has mostly been caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16). CA 16 was the most common cause of HFMD in 2010. EV71 had a high prevalence in 2008-2009 and has been identified with a higher frequency since 2011. Nearly complete genome sequences of three EV71 strains (2008-2009 strains) and two CA16 strains (2010 strains) obtained from outbreaks in Thailand in 2008 to 2010 were characterized. Based on a phylogenetic tree of the complete VP1 region, three EV71 strains grouped into the B5, C1 and C4 genotypes, and two CA16 strains grouped into the C genotype. Based on sequence analysis, nucleotide changes were found to cluster in the internal ribosome entry site (IRES) element of the 5'-untranslated region (5'-UTR). Amino acid differences identified in all strains were located in the non-structural protein. These data also provide the molecular epidemiology of EV71 and CA16 outbreaks in Thailand. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/21898187/Molecular_characterization_and_complete_genome_analysis_of_human_enterovirus_71_and_coxsackievirus_A16_from_children_with_hand_foot_and_mouth_disease_in_Thailand_during_2008_2011_ DB - PRIME DP - Unbound Medicine ER -