TY - JOUR T1 - Molecular characterization and complete genome analysis of human enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Thailand during 2008-2011. AU - Puenpa,Jiratchaya, AU - Theamboonlers,Apiradee, AU - Korkong,Sumeth, AU - Linsuwanon,Piyada, AU - Thongmee,Chittima, AU - Chatproedprai,Susheera, AU - Poovorawan,Yong, Y1 - 2011/09/07/ PY - 2011/07/04/received PY - 2011/08/25/accepted PY - 2011/9/8/entrez PY - 2011/9/8/pubmed PY - 2011/12/30/medline SP - 2007 EP - 13 JF - Archives of virology JO - Arch Virol VL - 156 IS - 11 N2 - Hand, foot and mouth disease (HFMD) has mostly been caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16). CA 16 was the most common cause of HFMD in 2010. EV71 had a high prevalence in 2008-2009 and has been identified with a higher frequency since 2011. Nearly complete genome sequences of three EV71 strains (2008-2009 strains) and two CA16 strains (2010 strains) obtained from outbreaks in Thailand in 2008 to 2010 were characterized. Based on a phylogenetic tree of the complete VP1 region, three EV71 strains grouped into the B5, C1 and C4 genotypes, and two CA16 strains grouped into the C genotype. Based on sequence analysis, nucleotide changes were found to cluster in the internal ribosome entry site (IRES) element of the 5'-untranslated region (5'-UTR). Amino acid differences identified in all strains were located in the non-structural protein. These data also provide the molecular epidemiology of EV71 and CA16 outbreaks in Thailand. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/21898187/Molecular_characterization_and_complete_genome_analysis_of_human_enterovirus_71_and_coxsackievirus_A16_from_children_with_hand_foot_and_mouth_disease_in_Thailand_during_2008_2011_ DB - PRIME DP - Unbound Medicine ER -