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Suzuki-Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow.
Org Lett. 2011 Oct 07; 13(19):5180-3.OL

Abstract

General continuous-flow conditions for the Suzuki-Miyaura cross-coupling of heteroaryl halides and (hetero)arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05-1.5 mol % Pd).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Noël T
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. tnoel@mit.edu
Musacchio AJ
No affiliation info available

MeSH

Boronic AcidsCatalysisHalogensHeterocyclic CompoundsLigandsMolecular Structure

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21899298

Citation

Noël, Timothy, and Andrew J. Musacchio. "Suzuki-Miyaura Cross-coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow." Organic Letters, vol. 13, no. 19, 2011, pp. 5180-3.
Noël T, Musacchio AJ. Suzuki-Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow. Org Lett. 2011;13(19):5180-3.
Noël, T., & Musacchio, A. J. (2011). Suzuki-Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow. Organic Letters, 13(19), 5180-3. https://doi.org/10.1021/ol202052q
Noël T, Musacchio AJ. Suzuki-Miyaura Cross-coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow. Org Lett. 2011 Oct 7;13(19):5180-3. PubMed PMID: 21899298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suzuki-Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow. AU - Noël,Timothy, AU - Musacchio,Andrew J, Y1 - 2011/09/07/ PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2012/1/18/medline SP - 5180 EP - 3 JF - Organic letters JO - Org Lett VL - 13 IS - 19 N2 - General continuous-flow conditions for the Suzuki-Miyaura cross-coupling of heteroaryl halides and (hetero)arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05-1.5 mol % Pd). SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/21899298/Suzuki_Miyaura_cross_coupling_of_heteroaryl_halides_and_arylboronic_acids_in_continuous_flow_ L2 - https://doi.org/10.1021/ol202052q DB - PRIME DP - Unbound Medicine ER -