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Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings.

Abstract

BACKGROUND

The relationship between cannabis use and cognitive functioning in patients with psychosis has yielded contradictory findings. In individuals at genetic high risk for psychosis, information is sparse. The aim of this study was to assess the association between recency and frequency of cannabis use and cognitive functioning in patients with psychosis and their unaffected siblings.

METHOD

We conducted a cross-sectional study in 956 patients with non-affective psychosis, 953 unaffected siblings, and 554 control subjects. Participants completed a cognitive test battery including assessments of verbal learning, set shifting, sustained attention, processing speed, working memory, acquired knowledge, reasoning and problem solving and social cognition. Cannabis use was assessed by urinalysis and by the Composite International Diagnostic Interview. Using random-effect regression models the main effects of cannabis (recency and frequency) and the interaction with status (patient, sibling, control) on cognitive functioning were assessed.

RESULTS

Current cannabis use was associated with poorer performance on immediate verbal learning, processing speed and working memory (Cohen's d -0.20 to -0.33, p<0.005). Lifetime cannabis use was associated with better performance on acquired knowledge, facial affect recognition and face identity recognition (Cohen's d+0.17 to +0.33, p<0.005). There was no significant interaction between cannabis and status on cognitive functioning.

CONCLUSIONS

Lifetime cannabis-using individuals might constitute a subgroup with a higher cognitive potential. The residual effects of cannabis may impair short-term memory and processing speed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.

    , , , , ,

    Source

    Psychological medicine 42:4 2012 Apr pg 705-16

    MeSH

    Adolescent
    Adult
    Cognition
    Cognition Disorders
    Cross-Sectional Studies
    Dronabinol
    Female
    Genetic Predisposition to Disease
    Humans
    Interview, Psychological
    Male
    Marijuana Abuse
    Middle Aged
    Neuropsychological Tests
    Psychotic Disorders
    Regression Analysis
    Schizophrenia
    Schizophrenic Psychology
    Siblings
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21899795

    Citation

    Meijer, J H., et al. "Cannabis and Cognitive Performance in Psychosis: a Cross-sectional Study in Patients With Non-affective Psychotic Illness and Their Unaffected Siblings." Psychological Medicine, vol. 42, no. 4, 2012, pp. 705-16.
    Meijer JH, Dekker N, Koeter MW, et al. Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings. Psychol Med. 2012;42(4):705-16.
    Meijer, J. H., Dekker, N., Koeter, M. W., Quee, P. J., van Beveren, N. J., & Meijer, C. J. (2012). Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings. Psychological Medicine, 42(4), pp. 705-16. doi:10.1017/S0033291711001656.
    Meijer JH, et al. Cannabis and Cognitive Performance in Psychosis: a Cross-sectional Study in Patients With Non-affective Psychotic Illness and Their Unaffected Siblings. Psychol Med. 2012;42(4):705-16. PubMed PMID: 21899795.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings. AU - Meijer,J H, AU - Dekker,N, AU - Koeter,M W, AU - Quee,P J, AU - van Beveren,N J M, AU - Meijer,C J, AU - ,, Y1 - 2011/09/07/ PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2012/9/8/medline SP - 705 EP - 16 JF - Psychological medicine JO - Psychol Med VL - 42 IS - 4 N2 - BACKGROUND: The relationship between cannabis use and cognitive functioning in patients with psychosis has yielded contradictory findings. In individuals at genetic high risk for psychosis, information is sparse. The aim of this study was to assess the association between recency and frequency of cannabis use and cognitive functioning in patients with psychosis and their unaffected siblings. METHOD: We conducted a cross-sectional study in 956 patients with non-affective psychosis, 953 unaffected siblings, and 554 control subjects. Participants completed a cognitive test battery including assessments of verbal learning, set shifting, sustained attention, processing speed, working memory, acquired knowledge, reasoning and problem solving and social cognition. Cannabis use was assessed by urinalysis and by the Composite International Diagnostic Interview. Using random-effect regression models the main effects of cannabis (recency and frequency) and the interaction with status (patient, sibling, control) on cognitive functioning were assessed. RESULTS: Current cannabis use was associated with poorer performance on immediate verbal learning, processing speed and working memory (Cohen's d -0.20 to -0.33, p<0.005). Lifetime cannabis use was associated with better performance on acquired knowledge, facial affect recognition and face identity recognition (Cohen's d+0.17 to +0.33, p<0.005). There was no significant interaction between cannabis and status on cognitive functioning. CONCLUSIONS: Lifetime cannabis-using individuals might constitute a subgroup with a higher cognitive potential. The residual effects of cannabis may impair short-term memory and processing speed. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/21899795/Cannabis_and_cognitive_performance_in_psychosis:_a_cross_sectional_study_in_patients_with_non_affective_psychotic_illness_and_their_unaffected_siblings_ L2 - https://www.cambridge.org/core/product/identifier/S0033291711001656/type/journal_article DB - PRIME DP - Unbound Medicine ER -