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Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action.
Br J Nutr 2012; 107(9):1316-23BJ

Abstract

Asparagus racemosus roots have been shown to enhance insulin secretion in perfused pancreas and isolated islets. The present study investigated the effects of ethanol extracts of A. racemosus roots on glucose homeostasis in diabetic rats, together with the effects on insulin action in 3T3 adipocytes. When administered orally together with glucose, A. racemosus extract improved glucose tolerance in normal as well as in two types of diabetic rats. To investigate the possible effects on carbohydrate absorption, the sucrose content of the gastrointestinal tract was examined in 12 h fasted rats after an oral sucrose load (2.5 g/kg body weight). The extract significantly suppressed postprandial hyperglycaemia after sucrose ingestion and reversibly increased unabsorbed sucrose content throughout the gut. The extract also significantly inhibited the absorption of glucose during in situ gut perfusion with glucose. Furthermore, the extract enhanced glucose transport and insulin action in 3T3-L1 adipocytes. Daily administration of A. racemosus to type 2 diabetic rats for 28 d decreased serum glucose, increased pancreatic insulin, plasma insulin, liver glycogen and total oxidant status. These findings indicate that antihyperglycaemic activity of A. racemosus is partly mediated by inhibition of carbohydrate digestion and absorption, together with enhancement of insulin secretion and action in the peripheral tissue. Asparagus racemosus may be useful as a source of novel antidiabetic compounds or a dietary adjunct for the management of diabetes.

Authors+Show Affiliations

Department of Pharmacy, North South University, Dhaka, Bangladesh.Research Division, BIRDEM, Dhaka, Bangladesh.Department of Pharmacy, North South University, Dhaka, Bangladesh.Research Division, BIRDEM, Dhaka, Bangladesh.SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21899804

Citation

Hannan, J M A., et al. "Antihyperglycaemic Activity of Asparagus Racemosus Roots Is Partly Mediated By Inhibition of Carbohydrate Digestion and Absorption, and Enhancement of Cellular Insulin Action." The British Journal of Nutrition, vol. 107, no. 9, 2012, pp. 1316-23.
Hannan JM, Ali L, Khaleque J, et al. Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. Br J Nutr. 2012;107(9):1316-23.
Hannan, J. M., Ali, L., Khaleque, J., Akhter, M., Flatt, P. R., & Abdel-Wahab, Y. H. (2012). Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. The British Journal of Nutrition, 107(9), pp. 1316-23. doi:10.1017/S0007114511004284.
Hannan JM, et al. Antihyperglycaemic Activity of Asparagus Racemosus Roots Is Partly Mediated By Inhibition of Carbohydrate Digestion and Absorption, and Enhancement of Cellular Insulin Action. Br J Nutr. 2012;107(9):1316-23. PubMed PMID: 21899804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action. AU - Hannan,J M A, AU - Ali,Liaquat, AU - Khaleque,Junaida, AU - Akhter,Masfida, AU - Flatt,Peter R, AU - Abdel-Wahab,Yasser H A, Y1 - 2011/09/08/ PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2014/5/28/medline SP - 1316 EP - 23 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 107 IS - 9 N2 - Asparagus racemosus roots have been shown to enhance insulin secretion in perfused pancreas and isolated islets. The present study investigated the effects of ethanol extracts of A. racemosus roots on glucose homeostasis in diabetic rats, together with the effects on insulin action in 3T3 adipocytes. When administered orally together with glucose, A. racemosus extract improved glucose tolerance in normal as well as in two types of diabetic rats. To investigate the possible effects on carbohydrate absorption, the sucrose content of the gastrointestinal tract was examined in 12 h fasted rats after an oral sucrose load (2.5 g/kg body weight). The extract significantly suppressed postprandial hyperglycaemia after sucrose ingestion and reversibly increased unabsorbed sucrose content throughout the gut. The extract also significantly inhibited the absorption of glucose during in situ gut perfusion with glucose. Furthermore, the extract enhanced glucose transport and insulin action in 3T3-L1 adipocytes. Daily administration of A. racemosus to type 2 diabetic rats for 28 d decreased serum glucose, increased pancreatic insulin, plasma insulin, liver glycogen and total oxidant status. These findings indicate that antihyperglycaemic activity of A. racemosus is partly mediated by inhibition of carbohydrate digestion and absorption, together with enhancement of insulin secretion and action in the peripheral tissue. Asparagus racemosus may be useful as a source of novel antidiabetic compounds or a dietary adjunct for the management of diabetes. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21899804/Antihyperglycaemic_activity_of_Asparagus_racemosus_roots_is_partly_mediated_by_inhibition_of_carbohydrate_digestion_and_absorption_and_enhancement_of_cellular_insulin_action_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511004284/type/journal_article DB - PRIME DP - Unbound Medicine ER -