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Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis.

Abstract

Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent. We conducted a systematic literature review and meta-analysis to evaluate the relationship between dietary intake of lutein and zeaxanthin and AMD risk. Relevant studies were identified by searching five databases up to April 2010. Reference lists of articles were retrieved, and experts were contacted. Literature search, data extraction and study quality assessment were performed independently by two reviewers and results were pooled quantitatively using meta-analysis methods. The potential sources of heterogeneity and publication bias were also estimated. The search yielded six longitudinal cohort studies. The pooled relative risk (RR) for early AMD, comparing the highest with the lowest category of lutein and zeaxanthin intake, was 0·96 (95 % CI 0·78, 1·17). Dietary intake of these carotenoids was significantly related with a reduction in risk of late AMD (RR 0·74; 95 % CI 0·57, 0·97); and a statistically significant inverse association was observed between lutein and zeaxanthin intake and neovascular AMD risk (RR 0·68; 95 % CI 0·51, 0·92). The results were essentially consistent among subgroups stratified by participant characteristics. The findings of the present meta-analysis indicate that dietary lutein and zeaxanthin is not significantly associated with a reduced risk of early AMD, whereas an increase in the intake of these carotenoids may be protective against late AMD. However, additional studies are needed to confirm these relationships.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, People's Republic of China.

    , , , , , ,

    Source

    The British journal of nutrition 107:3 2012 Feb pg 350-9

    MeSH

    Age of Onset
    Aged
    Diet
    Evidence-Based Medicine
    Humans
    Lutein
    Macular Degeneration
    Middle Aged
    Risk
    Wet Macular Degeneration
    Xanthophylls
    Zeaxanthins

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    21899805

    Citation

    Ma, Le, et al. "Lutein and Zeaxanthin Intake and the Risk of Age-related Macular Degeneration: a Systematic Review and Meta-analysis." The British Journal of Nutrition, vol. 107, no. 3, 2012, pp. 350-9.
    Ma L, Dou HL, Wu YQ, et al. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr. 2012;107(3):350-9.
    Ma, L., Dou, H. L., Wu, Y. Q., Huang, Y. M., Huang, Y. B., Xu, X. R., ... Lin, X. M. (2012). Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. The British Journal of Nutrition, 107(3), pp. 350-9. doi:10.1017/S0007114511004260.
    Ma L, et al. Lutein and Zeaxanthin Intake and the Risk of Age-related Macular Degeneration: a Systematic Review and Meta-analysis. Br J Nutr. 2012;107(3):350-9. PubMed PMID: 21899805.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. AU - Ma,Le, AU - Dou,Hong-Liang, AU - Wu,Yi-Qun, AU - Huang,Yang-Mu, AU - Huang,Yu-Bei, AU - Xu,Xian-Rong, AU - Zou,Zhi-Yong, AU - Lin,Xiao-Ming, Y1 - 2011/09/08/ PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2012/3/10/medline SP - 350 EP - 9 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 107 IS - 3 N2 - Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent. We conducted a systematic literature review and meta-analysis to evaluate the relationship between dietary intake of lutein and zeaxanthin and AMD risk. Relevant studies were identified by searching five databases up to April 2010. Reference lists of articles were retrieved, and experts were contacted. Literature search, data extraction and study quality assessment were performed independently by two reviewers and results were pooled quantitatively using meta-analysis methods. The potential sources of heterogeneity and publication bias were also estimated. The search yielded six longitudinal cohort studies. The pooled relative risk (RR) for early AMD, comparing the highest with the lowest category of lutein and zeaxanthin intake, was 0·96 (95 % CI 0·78, 1·17). Dietary intake of these carotenoids was significantly related with a reduction in risk of late AMD (RR 0·74; 95 % CI 0·57, 0·97); and a statistically significant inverse association was observed between lutein and zeaxanthin intake and neovascular AMD risk (RR 0·68; 95 % CI 0·51, 0·92). The results were essentially consistent among subgroups stratified by participant characteristics. The findings of the present meta-analysis indicate that dietary lutein and zeaxanthin is not significantly associated with a reduced risk of early AMD, whereas an increase in the intake of these carotenoids may be protective against late AMD. However, additional studies are needed to confirm these relationships. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21899805/Lutein_and_zeaxanthin_intake_and_the_risk_of_age_related_macular_degeneration:_a_systematic_review_and_meta_analysis_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511004260/type/journal_article DB - PRIME DP - Unbound Medicine ER -