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Low concentrations of serum 25-hydroxyvitamin D associated with increased risk for chronic bronchitis among US adults.
Br J Nutr. 2012 May; 107(9):1386-92.BJ

Abstract

Increasing evidence suggests that vitamin D benefits both innate and adaptive immunity, thereby eliciting an anti-inflammatory effect and reducing the risk of infectious disease. The present study examined the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of chronic bronchitis among US adults. We analysed data from 6872 US adults aged ≥ 20 years who participated in the 2003-6 National Health and Nutrition Examination Survey. Prevalence and OR with 95 % CI of having self-reported chronic bronchitis were estimated by quintiles of 25(OH)D or vitamin D-deficiency status after adjustment for potential confounders. The results showed that the adjusted prevalence of chronic bronchitis ranged from 2.4 (95 % CI 1.4, 3.3) % among adults in the highest quintile of 25(OH)D (≥ 30 ng/ml) to 4.1 (95 % CI 2.5, 5.6) % among adults in the lowest quintile (< 15 ng/ml; P for trend < 0.01). The adjusted OR for chronic bronchitis was 1.85 (95 % CI 1.06, 3.24) in adults with < 15 ng/ml 25(OH)D and 1.77 (95 % CI 1.19, 2.65) in those with 15 to < 20 ng/ml 25(OH)D compared with adults with ≥ 30 ng/ml 25(OH)D. Additionally, the adjusted OR for chronic bronchitis was 1.52 (95 % CI 1.03, 2.26) among adults with vitamin D deficiency (< 20 ng/ml 25(OH)D) compared with those with ≥ 20 ng/ml 25(OH)D. For every 1 ng/ml increase in 25(OH)D, the likelihood of having chronic bronchitis fell by 2.6 % (P = 0.016). In conclusion, low serum 25(OH)D levels are associated with the increased risk of chronic bronchitis among US adults. The present results provide support for continuing research on the role of vitamin D in lung diseases.

Authors+Show Affiliations

Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop K67, Atlanta, GA 30341, USA.Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop K67, Atlanta, GA 30341, USA.Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop K67, Atlanta, GA 30341, USA.Division of Behavioral Surveillance, Public Health Surveillance Program Office, Office of Surveillance, Epidemiology and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GA, USA.Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop K67, Atlanta, GA 30341, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21899806

Citation

Zhao, Guixiang, et al. "Low Concentrations of Serum 25-hydroxyvitamin D Associated With Increased Risk for Chronic Bronchitis Among US Adults." The British Journal of Nutrition, vol. 107, no. 9, 2012, pp. 1386-92.
Zhao G, Ford ES, Tsai J, et al. Low concentrations of serum 25-hydroxyvitamin D associated with increased risk for chronic bronchitis among US adults. Br J Nutr. 2012;107(9):1386-92.
Zhao, G., Ford, E. S., Tsai, J., Li, C., & Croft, J. B. (2012). Low concentrations of serum 25-hydroxyvitamin D associated with increased risk for chronic bronchitis among US adults. The British Journal of Nutrition, 107(9), 1386-92. https://doi.org/10.1017/S0007114511004417
Zhao G, et al. Low Concentrations of Serum 25-hydroxyvitamin D Associated With Increased Risk for Chronic Bronchitis Among US Adults. Br J Nutr. 2012;107(9):1386-92. PubMed PMID: 21899806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low concentrations of serum 25-hydroxyvitamin D associated with increased risk for chronic bronchitis among US adults. AU - Zhao,Guixiang, AU - Ford,Earl S, AU - Tsai,James, AU - Li,Chaoyang, AU - Croft,Janet B, Y1 - 2011/09/08/ PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2014/5/28/medline SP - 1386 EP - 92 JF - The British journal of nutrition JO - Br J Nutr VL - 107 IS - 9 N2 - Increasing evidence suggests that vitamin D benefits both innate and adaptive immunity, thereby eliciting an anti-inflammatory effect and reducing the risk of infectious disease. The present study examined the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of chronic bronchitis among US adults. We analysed data from 6872 US adults aged ≥ 20 years who participated in the 2003-6 National Health and Nutrition Examination Survey. Prevalence and OR with 95 % CI of having self-reported chronic bronchitis were estimated by quintiles of 25(OH)D or vitamin D-deficiency status after adjustment for potential confounders. The results showed that the adjusted prevalence of chronic bronchitis ranged from 2.4 (95 % CI 1.4, 3.3) % among adults in the highest quintile of 25(OH)D (≥ 30 ng/ml) to 4.1 (95 % CI 2.5, 5.6) % among adults in the lowest quintile (< 15 ng/ml; P for trend < 0.01). The adjusted OR for chronic bronchitis was 1.85 (95 % CI 1.06, 3.24) in adults with < 15 ng/ml 25(OH)D and 1.77 (95 % CI 1.19, 2.65) in those with 15 to < 20 ng/ml 25(OH)D compared with adults with ≥ 30 ng/ml 25(OH)D. Additionally, the adjusted OR for chronic bronchitis was 1.52 (95 % CI 1.03, 2.26) among adults with vitamin D deficiency (< 20 ng/ml 25(OH)D) compared with those with ≥ 20 ng/ml 25(OH)D. For every 1 ng/ml increase in 25(OH)D, the likelihood of having chronic bronchitis fell by 2.6 % (P = 0.016). In conclusion, low serum 25(OH)D levels are associated with the increased risk of chronic bronchitis among US adults. The present results provide support for continuing research on the role of vitamin D in lung diseases. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21899806/Low_concentrations_of_serum_25_hydroxyvitamin_D_associated_with_increased_risk_for_chronic_bronchitis_among_US_adults_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511004417/type/journal_article DB - PRIME DP - Unbound Medicine ER -