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Exposure to phthalates and phenols during pregnancy and offspring size at birth.
Environ Health Perspect. 2012 Mar; 120(3):464-70.EH

Abstract

BACKGROUND

Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight.

OBJECTIVE

Our aim was to assess the relationships between prenatal exposures to phthalates and phenols and fetal growth among male newborns.

METHODS

We conducted a case-control study on male malformations of the genitalia nested in two French mother-child cohorts with recruitment between 2002 and 2006. We measured, in maternal urinary samples collected between 6 and 30 gestational weeks, the concentrations (micrograms per liter) of 9 phenol (n = 191 pregnant women) and 11 phthalate metabolites (n = 287). Weight, length, and head circumference at birth were collected from maternity records. Statistical analyses were corrected for the oversampling of malformation cases.

RESULTS

Adjusted birth weight decreased by 77 g [95% confidence interval (CI): -129, -25] and by 49 g (95% CI: -86, -13) in association with a 1-unit increase in ln-transformed 2,4-dichlorophenol (DCP) and 2,5-DCP urinary concentrations, respectively. Benzophenone-3 (BP3) ln-transformed concentrations were positively associated with weight (26 g; 95% CI: -2, 54) and head circumference at birth (0.1 cm; 95% CI: 0.0, 0.2). Head circumference increased by 0.3 cm (95% CI: 0.0, 0.7) in association with a 1-unit increase in ln-transformed BPA concentration. For phthalate metabolites there was no evidence of monotonic associations with birth weight.

CONCLUSIONS

Consistent with findings of a previous study, we observed evidence of an inverse association of 2,5-DCP and a positive association of BP3 with male birth weight.

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale, Institut Albert Bonniot (U823), Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France. Claire.Philippat@e.ujf-grenoble.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21900077

Citation

Philippat, Claire, et al. "Exposure to Phthalates and Phenols During Pregnancy and Offspring Size at Birth." Environmental Health Perspectives, vol. 120, no. 3, 2012, pp. 464-70.
Philippat C, Mortamais M, Chevrier C, et al. Exposure to phthalates and phenols during pregnancy and offspring size at birth. Environ Health Perspect. 2012;120(3):464-70.
Philippat, C., Mortamais, M., Chevrier, C., Petit, C., Calafat, A. M., Ye, X., Silva, M. J., Brambilla, C., Pin, I., Charles, M. A., Cordier, S., & Slama, R. (2012). Exposure to phthalates and phenols during pregnancy and offspring size at birth. Environmental Health Perspectives, 120(3), 464-70. https://doi.org/10.1289/ehp.1103634
Philippat C, et al. Exposure to Phthalates and Phenols During Pregnancy and Offspring Size at Birth. Environ Health Perspect. 2012;120(3):464-70. PubMed PMID: 21900077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to phthalates and phenols during pregnancy and offspring size at birth. AU - Philippat,Claire, AU - Mortamais,Marion, AU - Chevrier,Cécile, AU - Petit,Claire, AU - Calafat,Antonia M, AU - Ye,Xiaoyun, AU - Silva,Manori J, AU - Brambilla,Christian, AU - Pin,Isabelle, AU - Charles,Marie-Aline, AU - Cordier,Sylvaine, AU - Slama,Rémy, Y1 - 2011/09/07/ PY - 2011/03/04/received PY - 2011/09/07/accepted PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2012/6/27/medline SP - 464 EP - 70 JF - Environmental health perspectives JO - Environ Health Perspect VL - 120 IS - 3 N2 - BACKGROUND: Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight. OBJECTIVE: Our aim was to assess the relationships between prenatal exposures to phthalates and phenols and fetal growth among male newborns. METHODS: We conducted a case-control study on male malformations of the genitalia nested in two French mother-child cohorts with recruitment between 2002 and 2006. We measured, in maternal urinary samples collected between 6 and 30 gestational weeks, the concentrations (micrograms per liter) of 9 phenol (n = 191 pregnant women) and 11 phthalate metabolites (n = 287). Weight, length, and head circumference at birth were collected from maternity records. Statistical analyses were corrected for the oversampling of malformation cases. RESULTS: Adjusted birth weight decreased by 77 g [95% confidence interval (CI): -129, -25] and by 49 g (95% CI: -86, -13) in association with a 1-unit increase in ln-transformed 2,4-dichlorophenol (DCP) and 2,5-DCP urinary concentrations, respectively. Benzophenone-3 (BP3) ln-transformed concentrations were positively associated with weight (26 g; 95% CI: -2, 54) and head circumference at birth (0.1 cm; 95% CI: 0.0, 0.2). Head circumference increased by 0.3 cm (95% CI: 0.0, 0.7) in association with a 1-unit increase in ln-transformed BPA concentration. For phthalate metabolites there was no evidence of monotonic associations with birth weight. CONCLUSIONS: Consistent with findings of a previous study, we observed evidence of an inverse association of 2,5-DCP and a positive association of BP3 with male birth weight. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/21900077/Exposure_to_phthalates_and_phenols_during_pregnancy_and_offspring_size_at_birth_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.1103634?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -