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The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial.
Breast Cancer Res Treat 2012; 131(1):99-109BC

Abstract

The aim of this study was determine the effectiveness of a mindfulness-based stress-reduction (MBSR) program on quality of life (QOL) and psychosocial outcomes in women with early-stage breast cancer, using a three-arm randomized controlled clinical trial (RCT). This RCT consisting of 172 women, aged 20-65 with stage I or II breast cancer consisted of the 8-week MBSR, which was compared to a nutrition education program (NEP) and usual supportive care (UC). Follow-up was performed at three post-intervention points: 4 months, 1, and 2 years. Standardized, validated self-administered questionnaires were adopted to assess psychosocial variables. Statistical analysis included descriptive and regression analyses incorporating both intention-to-treat and post hoc multivariable approaches of the 163 women with complete data at baseline, those who were randomized to MBSR experienced a significant improvement in the primary measures of QOL and coping outcomes compared to the NEP, UC, or both, including the spirituality subscale of the FACT-B as well as dealing with illness scale increases in active behavioral coping and active cognitive coping. Secondary outcome improvements resulting in significant between-group contrasts favoring the MBSR group at 4 months included meaningfulness, depression, paranoid ideation, hostility, anxiety, unhappiness, and emotional control. Results tended to decline at 12 months and even more at 24 months, though at all times, they were as robust in women with lower expectation of effect as in those with higher expectation. The MBSR intervention appears to benefit psychosocial adjustment in cancer patients, over and above the effects of usual care or a credible control condition. The universality of effects across levels of expectation indicates a potential to utilize this stress reduction approach as complementary therapy in oncologic practice.

Authors+Show Affiliations

Department of Family and Preventive Medicine, School of Medicine, University of South Carolina, 3209 Colonial Drive, Columbia, SC 29203, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21901389

Citation

Henderson, Virginia P., et al. "The Effects of Mindfulness-based Stress Reduction On Psychosocial Outcomes and Quality of Life in Early-stage Breast Cancer Patients: a Randomized Trial." Breast Cancer Research and Treatment, vol. 131, no. 1, 2012, pp. 99-109.
Henderson VP, Clemow L, Massion AO, et al. The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial. Breast Cancer Res Treat. 2012;131(1):99-109.
Henderson, V. P., Clemow, L., Massion, A. O., Hurley, T. G., Druker, S., & Hébert, J. R. (2012). The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial. Breast Cancer Research and Treatment, 131(1), pp. 99-109. doi:10.1007/s10549-011-1738-1.
Henderson VP, et al. The Effects of Mindfulness-based Stress Reduction On Psychosocial Outcomes and Quality of Life in Early-stage Breast Cancer Patients: a Randomized Trial. Breast Cancer Res Treat. 2012;131(1):99-109. PubMed PMID: 21901389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial. AU - Henderson,Virginia P, AU - Clemow,Lynn, AU - Massion,Ann O, AU - Hurley,Thomas G, AU - Druker,Susan, AU - Hébert,James R, Y1 - 2011/09/08/ PY - 2010/10/25/received PY - 2011/08/09/accepted PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2012/8/22/medline SP - 99 EP - 109 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 131 IS - 1 N2 - The aim of this study was determine the effectiveness of a mindfulness-based stress-reduction (MBSR) program on quality of life (QOL) and psychosocial outcomes in women with early-stage breast cancer, using a three-arm randomized controlled clinical trial (RCT). This RCT consisting of 172 women, aged 20-65 with stage I or II breast cancer consisted of the 8-week MBSR, which was compared to a nutrition education program (NEP) and usual supportive care (UC). Follow-up was performed at three post-intervention points: 4 months, 1, and 2 years. Standardized, validated self-administered questionnaires were adopted to assess psychosocial variables. Statistical analysis included descriptive and regression analyses incorporating both intention-to-treat and post hoc multivariable approaches of the 163 women with complete data at baseline, those who were randomized to MBSR experienced a significant improvement in the primary measures of QOL and coping outcomes compared to the NEP, UC, or both, including the spirituality subscale of the FACT-B as well as dealing with illness scale increases in active behavioral coping and active cognitive coping. Secondary outcome improvements resulting in significant between-group contrasts favoring the MBSR group at 4 months included meaningfulness, depression, paranoid ideation, hostility, anxiety, unhappiness, and emotional control. Results tended to decline at 12 months and even more at 24 months, though at all times, they were as robust in women with lower expectation of effect as in those with higher expectation. The MBSR intervention appears to benefit psychosocial adjustment in cancer patients, over and above the effects of usual care or a credible control condition. The universality of effects across levels of expectation indicates a potential to utilize this stress reduction approach as complementary therapy in oncologic practice. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/21901389/The_effects_of_mindfulness_based_stress_reduction_on_psychosocial_outcomes_and_quality_of_life_in_early_stage_breast_cancer_patients:_a_randomized_trial_ L2 - https://doi.org/10.1007/s10549-011-1738-1 DB - PRIME DP - Unbound Medicine ER -