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Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups.
Lipids. 2011 Dec; 46(12):1101-10.L

Abstract

Long-chain polyunsaturated fatty acids (LC-PUFA), particularly arachidonic acid (ARA) and docosahexaenoic acid (DHA), are considered critical for the development of infants and are commonly supplemented in infant formulae. In this study, two common sources of n-3 LC-PUFA, fish oil (FO) and DHA-rich microalgal oil (DMO), were fed to rat pups of mildly n-3 PUFA-deficient dams to compare changes in LC-PUFA of tissue phospholipids. The milk from dams fed a n-3 PUFA-deficient diet contained less n-3 LC-PUFA than that of dams fed a control diet (AIN-93G). The pups' were given orally 1 mg/g weight of either FO or DMO for 17 days between the ages of 5 and 21 days, the pups were weaned, and sacrificed 1 week later for analysis of fatty acid compositions of brain, heart, kidney, spleen, and thymus phospholipids. Although both FO and DMO brought about a recovery in the tissue DHA levels compared to those of the control group (pups from AIN-93G-fed dams), DMO was more effective at restoring tissue LC-PUFA status because it was richer in DHA than FO. FO had a slightly lower PUFA level than that required to bring the LC-PUFA status completely to normal levels in this experiment, and EPA did not accumulate in tissues under the conditions tested here. These results demonstrate the effectiveness of ingesting either FO or DMO in the pre-weaning period for improving mild n-3 PUFA deficiency.

Authors+Show Affiliations

Graduate School of Agricultural Science, Tohoku University, Aoba-ku, Sendai, Japan. f_kimura@biochem.tohoku.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21901511

Citation

Kimura, Fumiko, et al. "Supplementation of DHA-rich Microalgal Oil or Fish Oil During the Suckling Period in Mildly N-3 Fatty Acid-deficient Rat Pups." Lipids, vol. 46, no. 12, 2011, pp. 1101-10.
Kimura F, Ito S, Endo Y, et al. Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. Lipids. 2011;46(12):1101-10.
Kimura, F., Ito, S., Endo, Y., Doisaki, N., Koriyama, T., Miyazawa, T., & Fujimoto, K. (2011). Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. Lipids, 46(12), 1101-10. https://doi.org/10.1007/s11745-011-3608-3
Kimura F, et al. Supplementation of DHA-rich Microalgal Oil or Fish Oil During the Suckling Period in Mildly N-3 Fatty Acid-deficient Rat Pups. Lipids. 2011;46(12):1101-10. PubMed PMID: 21901511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. AU - Kimura,Fumiko, AU - Ito,Shiho, AU - Endo,Yasushi, AU - Doisaki,Nobushige, AU - Koriyama,Tsuyoshi, AU - Miyazawa,Teruo, AU - Fujimoto,Kenshiro, Y1 - 2011/09/07/ PY - 2011/02/22/received PY - 2011/08/12/accepted PY - 2011/9/9/entrez PY - 2011/9/9/pubmed PY - 2012/3/1/medline SP - 1101 EP - 10 JF - Lipids JO - Lipids VL - 46 IS - 12 N2 - Long-chain polyunsaturated fatty acids (LC-PUFA), particularly arachidonic acid (ARA) and docosahexaenoic acid (DHA), are considered critical for the development of infants and are commonly supplemented in infant formulae. In this study, two common sources of n-3 LC-PUFA, fish oil (FO) and DHA-rich microalgal oil (DMO), were fed to rat pups of mildly n-3 PUFA-deficient dams to compare changes in LC-PUFA of tissue phospholipids. The milk from dams fed a n-3 PUFA-deficient diet contained less n-3 LC-PUFA than that of dams fed a control diet (AIN-93G). The pups' were given orally 1 mg/g weight of either FO or DMO for 17 days between the ages of 5 and 21 days, the pups were weaned, and sacrificed 1 week later for analysis of fatty acid compositions of brain, heart, kidney, spleen, and thymus phospholipids. Although both FO and DMO brought about a recovery in the tissue DHA levels compared to those of the control group (pups from AIN-93G-fed dams), DMO was more effective at restoring tissue LC-PUFA status because it was richer in DHA than FO. FO had a slightly lower PUFA level than that required to bring the LC-PUFA status completely to normal levels in this experiment, and EPA did not accumulate in tissues under the conditions tested here. These results demonstrate the effectiveness of ingesting either FO or DMO in the pre-weaning period for improving mild n-3 PUFA deficiency. SN - 1558-9307 UR - https://www.unboundmedicine.com/medline/citation/21901511/Supplementation_of_DHA_rich_microalgal_oil_or_fish_oil_during_the_suckling_period_in_mildly_n_3_fatty_acid_deficient_rat_pups_ L2 - https://link.springer.com/article/10.1007/s11745-011-3608-3 DB - PRIME DP - Unbound Medicine ER -