Tags

Type your tag names separated by a space and hit enter

Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial.
Stroke 2011; 42(11):3168-75S

Abstract

BACKGROUND AND PURPOSE

Although epidemiological and experimental studies suggest that dietary intake of soy may be cardioprotective, use of isoflavone soy protein (ISP) supplementation as a primary preventive therapy remains unexplored. We determined whether ISP reduces subclinical atherosclerosis assessed as carotid artery intima-media thickness progression.

METHODS

In a double-blind, placebo-controlled trial, 350 postmenopausal women 45 to 92 years of age without diabetes and cardiovascular disease were randomized to 2 evenly divided daily doses of 25 g soy protein containing 91 mg aglycon isoflavone equivalents or placebo for 2.7 years.

RESULTS

Overall, mean (95% CI) carotid artery intima-media thickness progression rate was 4.77 (3.39-6.16) μm/year in the ISP group and 5.68 (4.30-7.06) μm/year in the placebo group. Although carotid artery intima-media thickness progression was reduced on average by 16% in the ISP group relative to the placebo group, this treatment effect was not statistically significant (P=0.36). Among the subgroup of women who were randomized within 5 years of menopause, ISP participants had on average a 68% lower carotid artery intima-media thickness progression rate than placebo participants 2.16 (-1.10 to 5.43) versus 6.79 (3.56-10.01) μm/year (P=0.05). ISP supplementation had a null effect on women who were >5 years beyond menopause when randomized. There were no major adverse events from ISP supplementation.

CONCLUSIONS

ISP supplementation did not significantly reduce subclinical atherosclerosis progression in postmenopausal women. Subgroup analysis suggests that ISP supplementation may reduce subclinical atherosclerosis in healthy young (median age, 53 years) women at low-risk for cardiovascular disease who were <5 years postmenopausal. These first trial results of their kind warrant further investigation.

Authors+Show Affiliations

USC Keck School of Medicine, Atherosclerosis Research Unit, 2250 Alcazar Street, CSC132, Los Angeles, CA 90033, USA. athero@usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21903957

Citation

Hodis, Howard N., et al. "Isoflavone Soy Protein Supplementation and Atherosclerosis Progression in Healthy Postmenopausal Women: a Randomized Controlled Trial." Stroke, vol. 42, no. 11, 2011, pp. 3168-75.
Hodis HN, Mack WJ, Kono N, et al. Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial. Stroke. 2011;42(11):3168-75.
Hodis, H. N., Mack, W. J., Kono, N., Azen, S. P., Shoupe, D., Hwang-Levine, J., ... Selzer, R. H. (2011). Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial. Stroke, 42(11), pp. 3168-75. doi:10.1161/STROKEAHA.111.620831.
Hodis HN, et al. Isoflavone Soy Protein Supplementation and Atherosclerosis Progression in Healthy Postmenopausal Women: a Randomized Controlled Trial. Stroke. 2011;42(11):3168-75. PubMed PMID: 21903957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial. AU - Hodis,Howard N, AU - Mack,Wendy J, AU - Kono,Naoko, AU - Azen,Stanley P, AU - Shoupe,Donna, AU - Hwang-Levine,Juliana, AU - Petitti,Diana, AU - Whitfield-Maxwell,Lora, AU - Yan,Mingzhu, AU - Franke,Adrian A, AU - Selzer,Robert H, AU - ,, Y1 - 2011/09/08/ PY - 2011/9/10/entrez PY - 2011/9/10/pubmed PY - 2012/8/14/medline SP - 3168 EP - 75 JF - Stroke JO - Stroke VL - 42 IS - 11 N2 - BACKGROUND AND PURPOSE: Although epidemiological and experimental studies suggest that dietary intake of soy may be cardioprotective, use of isoflavone soy protein (ISP) supplementation as a primary preventive therapy remains unexplored. We determined whether ISP reduces subclinical atherosclerosis assessed as carotid artery intima-media thickness progression. METHODS: In a double-blind, placebo-controlled trial, 350 postmenopausal women 45 to 92 years of age without diabetes and cardiovascular disease were randomized to 2 evenly divided daily doses of 25 g soy protein containing 91 mg aglycon isoflavone equivalents or placebo for 2.7 years. RESULTS: Overall, mean (95% CI) carotid artery intima-media thickness progression rate was 4.77 (3.39-6.16) μm/year in the ISP group and 5.68 (4.30-7.06) μm/year in the placebo group. Although carotid artery intima-media thickness progression was reduced on average by 16% in the ISP group relative to the placebo group, this treatment effect was not statistically significant (P=0.36). Among the subgroup of women who were randomized within 5 years of menopause, ISP participants had on average a 68% lower carotid artery intima-media thickness progression rate than placebo participants 2.16 (-1.10 to 5.43) versus 6.79 (3.56-10.01) μm/year (P=0.05). ISP supplementation had a null effect on women who were >5 years beyond menopause when randomized. There were no major adverse events from ISP supplementation. CONCLUSIONS: ISP supplementation did not significantly reduce subclinical atherosclerosis progression in postmenopausal women. Subgroup analysis suggests that ISP supplementation may reduce subclinical atherosclerosis in healthy young (median age, 53 years) women at low-risk for cardiovascular disease who were <5 years postmenopausal. These first trial results of their kind warrant further investigation. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/21903957/Isoflavone_soy_protein_supplementation_and_atherosclerosis_progression_in_healthy_postmenopausal_women:_a_randomized_controlled_trial_ L2 - http://www.ahajournals.org/doi/full/10.1161/STROKEAHA.111.620831?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -