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Effect of dialysis modality on survival of hepatitis C-infected ESRF patients.
Clin J Am Soc Nephrol. 2011 Nov; 6(11):2657-61.CJ

Abstract

BACKGROUND AND OBJECTIVES

Hepatitis C virus (HCV) infection is associated with increased mortality and morbidity in end-stage renal failure (ESRF) patients. Despite a lower incidence and risk of transmission of HCV infection with peritoneal dialysis (PD), the optimal dialysis modality for HCV-infected ESRF patients is not known. The aim of this study was to evaluate the impact of dialysis modality on the survival of HCV-infected ESRF patients.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

The study included all adult incident ESRF patients in Australia and New Zealand who commenced dialysis between January 1, 1994, and December 31, 2008, and were HCV antibody-positive at the time of dialysis commencement. Time to all-cause mortality was compared between hemodialysis (HD) and PD according to modality assignment at day 90, using Cox proportional hazards model analysis.

RESULTS

A total of 424 HCV-infected ESRF patients commenced dialysis during the study period and survived for at least 90 days (PD n = 134; HD n = 290). Mortality rates were comparable between PD and HD in the first year (10.7 versus 13.8 deaths per 100 patient-years, respectively; adjusted hazard ratio [HR] 0.65, 95% CI 0.34 to 1.26) and thereafter (20 versus 15.9 deaths per 100 patient-years, respectively; HR 1.27, 95% CI 0.86 to 1.88).

CONCLUSIONS

The survival of HCV-infected ESRF patients is comparable between PD and HD.

Authors+Show Affiliations

Australia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

21903989

Citation

Bose, Bhadran, et al. "Effect of Dialysis Modality On Survival of Hepatitis C-infected ESRF Patients." Clinical Journal of the American Society of Nephrology : CJASN, vol. 6, no. 11, 2011, pp. 2657-61.
Bose B, McDonald SP, Hawley CM, et al. Effect of dialysis modality on survival of hepatitis C-infected ESRF patients. Clin J Am Soc Nephrol. 2011;6(11):2657-61.
Bose, B., McDonald, S. P., Hawley, C. M., Brown, F. G., Badve, S. V., Wiggins, K. J., Bannister, K. M., Boudville, N., Clayton, P., & Johnson, D. W. (2011). Effect of dialysis modality on survival of hepatitis C-infected ESRF patients. Clinical Journal of the American Society of Nephrology : CJASN, 6(11), 2657-61. https://doi.org/10.2215/CJN.02200311
Bose B, et al. Effect of Dialysis Modality On Survival of Hepatitis C-infected ESRF Patients. Clin J Am Soc Nephrol. 2011;6(11):2657-61. PubMed PMID: 21903989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dialysis modality on survival of hepatitis C-infected ESRF patients. AU - Bose,Bhadran, AU - McDonald,Stephen P, AU - Hawley,Carmel M, AU - Brown,Fiona G, AU - Badve,Sunil V, AU - Wiggins,Kathryn J, AU - Bannister,Kym M, AU - Boudville,Neil, AU - Clayton,Philip, AU - Johnson,David W, Y1 - 2011/09/08/ PY - 2011/9/10/entrez PY - 2011/9/10/pubmed PY - 2012/3/1/medline SP - 2657 EP - 61 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 6 IS - 11 N2 - BACKGROUND AND OBJECTIVES: Hepatitis C virus (HCV) infection is associated with increased mortality and morbidity in end-stage renal failure (ESRF) patients. Despite a lower incidence and risk of transmission of HCV infection with peritoneal dialysis (PD), the optimal dialysis modality for HCV-infected ESRF patients is not known. The aim of this study was to evaluate the impact of dialysis modality on the survival of HCV-infected ESRF patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The study included all adult incident ESRF patients in Australia and New Zealand who commenced dialysis between January 1, 1994, and December 31, 2008, and were HCV antibody-positive at the time of dialysis commencement. Time to all-cause mortality was compared between hemodialysis (HD) and PD according to modality assignment at day 90, using Cox proportional hazards model analysis. RESULTS: A total of 424 HCV-infected ESRF patients commenced dialysis during the study period and survived for at least 90 days (PD n = 134; HD n = 290). Mortality rates were comparable between PD and HD in the first year (10.7 versus 13.8 deaths per 100 patient-years, respectively; adjusted hazard ratio [HR] 0.65, 95% CI 0.34 to 1.26) and thereafter (20 versus 15.9 deaths per 100 patient-years, respectively; HR 1.27, 95% CI 0.86 to 1.88). CONCLUSIONS: The survival of HCV-infected ESRF patients is comparable between PD and HD. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/21903989/Effect_of_dialysis_modality_on_survival_of_hepatitis_C_infected_ESRF_patients_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=21903989 DB - PRIME DP - Unbound Medicine ER -