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Serum cadmium levels are independently associated with endothelial function in hemodialysis patients.
Int Urol Nephrol 2012; 44(5):1487-92IU

Abstract

OBJECTIVE

Hemodialysis (HD) patients are at risk of deficiency of essential trace elements and excess of toxic trace elements. The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, and lead) and endothelial function in HD patients.

METHODS

Forty-eight chronic HD patients without known atherosclerotic disease and 42 age- and sex-matched healthy individuals were included in the study. The serum levels of trace elements (iron, zinc, manganese, copper, and magnesium) and heavy metals (cobalt, cadmium, and lead) were measured by Atomic Adsorption Spectrophotometer (UNICAM-929).

RESULTS

The serum levels of iron, zinc, and manganese were lower, and levels of copper, magnesium, cobalt, cadmium, and lead were higher in HD patients compared to controls. Flow-mediated dilatation (FMD %) in HD patients was lower than that in the control group (7.27 ± 0.76 vs. 11.29 ± 0.82, P < 0.001). There was a significant negative correlation between FMD % and serum levels of cobalt (r = -0.313, P = 0.03) and cadmium (r = -0.524, P < 0.01). A linear regression analysis showed that serum cadmium levels were still significantly and negatively correlated with FMD % (regression coefficient = -0.526, P < 0.001).

CONCLUSION

We first demonstrated that serum cadmium levels independently predict endothelial function in HD patients without known atherosclerotic disease.

Authors+Show Affiliations

Department of Cardiology, Van Yuksek Ihtisas Hospital, 65200 Van, Turkey. dryuksel_kaya@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21904850

Citation

Kaya, Yuksel, et al. "Serum Cadmium Levels Are Independently Associated With Endothelial Function in Hemodialysis Patients." International Urology and Nephrology, vol. 44, no. 5, 2012, pp. 1487-92.
Kaya Y, Ari E, Demir H, et al. Serum cadmium levels are independently associated with endothelial function in hemodialysis patients. Int Urol Nephrol. 2012;44(5):1487-92.
Kaya, Y., Ari, E., Demir, H., Gecit, I., Beytur, A., & Kaspar, C. (2012). Serum cadmium levels are independently associated with endothelial function in hemodialysis patients. International Urology and Nephrology, 44(5), pp. 1487-92. doi:10.1007/s11255-011-0055-2.
Kaya Y, et al. Serum Cadmium Levels Are Independently Associated With Endothelial Function in Hemodialysis Patients. Int Urol Nephrol. 2012;44(5):1487-92. PubMed PMID: 21904850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cadmium levels are independently associated with endothelial function in hemodialysis patients. AU - Kaya,Yuksel, AU - Ari,Elif, AU - Demir,Halit, AU - Gecit,Ilhan, AU - Beytur,Ali, AU - Kaspar,Cigdem, Y1 - 2011/09/09/ PY - 2011/03/03/received PY - 2011/08/23/accepted PY - 2011/9/10/entrez PY - 2011/9/10/pubmed PY - 2013/4/5/medline SP - 1487 EP - 92 JF - International urology and nephrology JO - Int Urol Nephrol VL - 44 IS - 5 N2 - OBJECTIVE: Hemodialysis (HD) patients are at risk of deficiency of essential trace elements and excess of toxic trace elements. The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, and lead) and endothelial function in HD patients. METHODS: Forty-eight chronic HD patients without known atherosclerotic disease and 42 age- and sex-matched healthy individuals were included in the study. The serum levels of trace elements (iron, zinc, manganese, copper, and magnesium) and heavy metals (cobalt, cadmium, and lead) were measured by Atomic Adsorption Spectrophotometer (UNICAM-929). RESULTS: The serum levels of iron, zinc, and manganese were lower, and levels of copper, magnesium, cobalt, cadmium, and lead were higher in HD patients compared to controls. Flow-mediated dilatation (FMD %) in HD patients was lower than that in the control group (7.27 ± 0.76 vs. 11.29 ± 0.82, P < 0.001). There was a significant negative correlation between FMD % and serum levels of cobalt (r = -0.313, P = 0.03) and cadmium (r = -0.524, P < 0.01). A linear regression analysis showed that serum cadmium levels were still significantly and negatively correlated with FMD % (regression coefficient = -0.526, P < 0.001). CONCLUSION: We first demonstrated that serum cadmium levels independently predict endothelial function in HD patients without known atherosclerotic disease. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/21904850/Serum_cadmium_levels_are_independently_associated_with_endothelial_function_in_hemodialysis_patients_ L2 - https://doi.org/10.1007/s11255-011-0055-2 DB - PRIME DP - Unbound Medicine ER -