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The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes.
Int J Geriatr Psychiatry 2011; 26(10):1062-70IJ

Abstract

BACKGROUND

Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes.

METHODS

APOE genotyping, a comprehensive geriatric assessment (CGA), and Neuropsychiatric Inventory were performed on 322 consecutive older patients. Patients were divided into three groups: AD with NPS (N = 93), AD without NPS (N = 108), and, as a control group, patients with no cognitive impairment (NoCI: N = 121). Patients with NPS were further sub-divided in four groups according to the European Alzheimer's Disease Consortium (EADC) classification of neuropsychiatric syndromes in AD: hyperactive, psychotic, affective, and apathetic.

RESULTS

AD patients with NPS showed a significantly higher grade of cognitive impairment, more severity stage of dementia, more disability in the activities of daily living (ADL), and the instrumental ADL than AD patients without NPS. As expected, an higher frequency of APOE ε3/ε4 genotype was observed in patients with AD, both with and without NPS, than patients with NoCI. No difference in the distribution of APOE genotypes was found between AD patients with vs. without NPS. However, in AD patients APOE ε4-carriers, there was an increased risk of affective [odds ratio (OR): 2.34, 95% confidence interval (CI): 1.19-4.58) and apathetic (OR: 2.24,95%CI: 1.19-4.22) syndromes.

CONCLUSIONS

These findings did not suggest a significant association between APOE polymorphism and presence of NPS in AD patients. In AD patients with NPS, however, APOE ε4-carrier status was associated with an increased risk of affective and apathetic syndromes.

Authors+Show Affiliations

Geriatrics Unit and Gerontology-Geriatric Research Laboratory, Department of Medical Sciences, IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, FG, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21905100

Citation

D'Onofrio, Grazia, et al. "The APOE Polymorphism in Alzheimer's Disease Patients With Neuropsychiatric Symptoms and Syndromes." International Journal of Geriatric Psychiatry, vol. 26, no. 10, 2011, pp. 1062-70.
D'Onofrio G, Panza F, Seripa D, et al. The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes. Int J Geriatr Psychiatry. 2011;26(10):1062-70.
D'Onofrio, G., Panza, F., Seripa, D., Sancarlo, D., Paris, F., Cascavilla, L., ... Pilotto, A. (2011). The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes. International Journal of Geriatric Psychiatry, 26(10), pp. 1062-70. doi:10.1002/gps.2644.
D'Onofrio G, et al. The APOE Polymorphism in Alzheimer's Disease Patients With Neuropsychiatric Symptoms and Syndromes. Int J Geriatr Psychiatry. 2011;26(10):1062-70. PubMed PMID: 21905100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes. AU - D'Onofrio,Grazia, AU - Panza,Francesco, AU - Seripa,Davide, AU - Sancarlo,Daniele, AU - Paris,Francesco, AU - Cascavilla,Leandro, AU - Urbano,Maria, AU - Gravina,Carolina, AU - Fontana,Andrea, AU - Solfrizzi,Vincenzo, AU - Pellegrini,Fabio, AU - Pilotto,Alberto, Y1 - 2010/10/29/ PY - 2010/01/27/received PY - 2010/09/03/accepted PY - 2011/9/10/entrez PY - 2011/9/10/pubmed PY - 2011/12/22/medline SP - 1062 EP - 70 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 26 IS - 10 N2 - BACKGROUND: Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes. METHODS: APOE genotyping, a comprehensive geriatric assessment (CGA), and Neuropsychiatric Inventory were performed on 322 consecutive older patients. Patients were divided into three groups: AD with NPS (N = 93), AD without NPS (N = 108), and, as a control group, patients with no cognitive impairment (NoCI: N = 121). Patients with NPS were further sub-divided in four groups according to the European Alzheimer's Disease Consortium (EADC) classification of neuropsychiatric syndromes in AD: hyperactive, psychotic, affective, and apathetic. RESULTS: AD patients with NPS showed a significantly higher grade of cognitive impairment, more severity stage of dementia, more disability in the activities of daily living (ADL), and the instrumental ADL than AD patients without NPS. As expected, an higher frequency of APOE ε3/ε4 genotype was observed in patients with AD, both with and without NPS, than patients with NoCI. No difference in the distribution of APOE genotypes was found between AD patients with vs. without NPS. However, in AD patients APOE ε4-carriers, there was an increased risk of affective [odds ratio (OR): 2.34, 95% confidence interval (CI): 1.19-4.58) and apathetic (OR: 2.24,95%CI: 1.19-4.22) syndromes. CONCLUSIONS: These findings did not suggest a significant association between APOE polymorphism and presence of NPS in AD patients. In AD patients with NPS, however, APOE ε4-carrier status was associated with an increased risk of affective and apathetic syndromes. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/21905100/The_APOE_polymorphism_in_Alzheimer's_disease_patients_with_neuropsychiatric_symptoms_and_syndromes_ L2 - https://doi.org/10.1002/gps.2644 DB - PRIME DP - Unbound Medicine ER -