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Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin?
Neuroscience. 2012 Mar 01; 204:186-92.N

Abstract

The transient receptor potential vanilloid type 1 channel (TRPV1; originally vanilloid receptor VR1) is activated in peripheral terminals of nociceptive fibers by noxious heat, low pH, and natural products such as capsaicin, the pungent ingredient of red-hot chilli peppers. Evidence has been accumulating that TRPV1 is expressed also in the brain, where it seems to be involved in antinociception, locomotor control, and regulation of affective behaviors. This ion channel might be activated by arachidonoyl ethanolamide (anandamide), the endogenous agonist of the cannabinoid type 1 (CB(1)) receptor. However, while CB(1) activation leads to a decrease in intracellular calcium and attenuation of synaptic transmission, anandamide binding to TRPV1 results in elevated calcium levels and potentiated synaptic transmission. This suggests a tripartite regulatory system with antagonistic effects of CB(1) and TRPV1, which are tied together by the same endogenous ligand. Such a system may have important implication for the modulation of behavioral responses. The present commentary elaborates on this interplay between CB(1) receptors and TRPV1 channels in the context of fear- and anxiety-related behaviors.

Authors+Show Affiliations

Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, MG, Brazil. fabriciomoreira@icb.ufmg.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21906661

Citation

Moreira, F A., et al. "Cannabinoid Type 1 Receptors and Transient Receptor Potential Vanilloid Type 1 Channels in Fear and Anxiety-two Sides of One Coin?" Neuroscience, vol. 204, 2012, pp. 186-92.
Moreira FA, Aguiar DC, Terzian AL, et al. Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin? Neuroscience. 2012;204:186-92.
Moreira, F. A., Aguiar, D. C., Terzian, A. L., Guimarães, F. S., & Wotjak, C. T. (2012). Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin? Neuroscience, 204, 186-92. https://doi.org/10.1016/j.neuroscience.2011.08.046
Moreira FA, et al. Cannabinoid Type 1 Receptors and Transient Receptor Potential Vanilloid Type 1 Channels in Fear and Anxiety-two Sides of One Coin. Neuroscience. 2012 Mar 1;204:186-92. PubMed PMID: 21906661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin? AU - Moreira,F A, AU - Aguiar,D C, AU - Terzian,A L B, AU - Guimarães,F S, AU - Wotjak,C T, Y1 - 2011/08/27/ PY - 2011/06/20/received PY - 2011/08/16/revised PY - 2011/08/22/accepted PY - 2011/9/13/entrez PY - 2011/9/13/pubmed PY - 2012/7/24/medline SP - 186 EP - 92 JF - Neuroscience JO - Neuroscience VL - 204 N2 - The transient receptor potential vanilloid type 1 channel (TRPV1; originally vanilloid receptor VR1) is activated in peripheral terminals of nociceptive fibers by noxious heat, low pH, and natural products such as capsaicin, the pungent ingredient of red-hot chilli peppers. Evidence has been accumulating that TRPV1 is expressed also in the brain, where it seems to be involved in antinociception, locomotor control, and regulation of affective behaviors. This ion channel might be activated by arachidonoyl ethanolamide (anandamide), the endogenous agonist of the cannabinoid type 1 (CB(1)) receptor. However, while CB(1) activation leads to a decrease in intracellular calcium and attenuation of synaptic transmission, anandamide binding to TRPV1 results in elevated calcium levels and potentiated synaptic transmission. This suggests a tripartite regulatory system with antagonistic effects of CB(1) and TRPV1, which are tied together by the same endogenous ligand. Such a system may have important implication for the modulation of behavioral responses. The present commentary elaborates on this interplay between CB(1) receptors and TRPV1 channels in the context of fear- and anxiety-related behaviors. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/21906661/Cannabinoid_type_1_receptors_and_transient_receptor_potential_vanilloid_type_1_channels_in_fear_and_anxiety_two_sides_of_one_coin L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(11)00988-2 DB - PRIME DP - Unbound Medicine ER -