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Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity.
Neuroimage. 2012 Jan 16; 59(2):1429-40.N

Abstract

Alzheimer's disease (AD), the most prevalent cause of dementia in the elderly, is characterized by progressive cognitive and intellectual deficits. Most patients with mild cognitive impairment (MCI) are thought to be in a very early stage of AD. Resting-state functional magnetic resonance imaging reflects spontaneous brain activities and/or the endogenous/background neurophysiological process of the human brain. Regional Homogeneity (ReHo) can provide a fast method for mapping regional activity across the whole brain. Little has been previously published about where or how spontaneous activity differs between MCI and AD, although many previous fMRI studies have shown that the activity pattern is altered in MCI/AD. In the present study, we first used the ReHo method to explore differences in regional spontaneous activities throughout the whole brain between normal controls (NC) and people with MCI and with AD. A one-way ANOVA was performed to determine the regions in which the ReHo differs between the three groups, and then a post hoc analysis was performed to evaluate differences in the pattern among the three groups. Finally a correlation analysis was done between the ReHo index of these regions and clinical variables in order to evaluate the relationship between ReHo and cognitive measures in the AD and MCI groups. An exploratory classification analysis also demonstrated that ReHo measures were able to correctly separate subjects in 71.4% of the cases. Altered brain spontaneous activations were found in the medial prefrontal cortex, the bilateral posterior cingulate gyrus/precuneus and the left inferior parietal lobule (IPL) in both MCI and AD. In MCI, the ReHo index in the left IPL was higher than that of the NC, which could indicate the presence of a compensatory mechanism in MCI. More obviously, the correlation analysis indicated that the lower the memory and other cognitive abilities, the lower the ReHo in patients with MCI and AD. Combining our findings with the results in earlier studies, we propose that the spontaneous activity pattern in the resting state could potentially be used as a clinical marker for MCI/AD.

Authors+Show Affiliations

Department of Neurology, Institute of Geriatrics and Gerontology, Chinese PLA General Hospital, Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21907292

Citation

Zhang, Zengqiang, et al. "Altered Spontaneous Activity in Alzheimer's Disease and Mild Cognitive Impairment Revealed By Regional Homogeneity." NeuroImage, vol. 59, no. 2, 2012, pp. 1429-40.
Zhang Z, Liu Y, Jiang T, et al. Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity. Neuroimage. 2012;59(2):1429-40.
Zhang, Z., Liu, Y., Jiang, T., Zhou, B., An, N., Dai, H., Wang, P., Niu, Y., Wang, L., & Zhang, X. (2012). Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity. NeuroImage, 59(2), 1429-40. https://doi.org/10.1016/j.neuroimage.2011.08.049
Zhang Z, et al. Altered Spontaneous Activity in Alzheimer's Disease and Mild Cognitive Impairment Revealed By Regional Homogeneity. Neuroimage. 2012 Jan 16;59(2):1429-40. PubMed PMID: 21907292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity. AU - Zhang,Zengqiang, AU - Liu,Yong, AU - Jiang,Tianzi, AU - Zhou,Bo, AU - An,Ningyu, AU - Dai,Haitao, AU - Wang,Pan, AU - Niu,Yixuan, AU - Wang,Luning, AU - Zhang,Xi, Y1 - 2011/08/30/ PY - 2011/05/21/received PY - 2011/08/14/revised PY - 2011/08/17/accepted PY - 2011/9/13/entrez PY - 2011/9/13/pubmed PY - 2012/4/18/medline SP - 1429 EP - 40 JF - NeuroImage JO - Neuroimage VL - 59 IS - 2 N2 - Alzheimer's disease (AD), the most prevalent cause of dementia in the elderly, is characterized by progressive cognitive and intellectual deficits. Most patients with mild cognitive impairment (MCI) are thought to be in a very early stage of AD. Resting-state functional magnetic resonance imaging reflects spontaneous brain activities and/or the endogenous/background neurophysiological process of the human brain. Regional Homogeneity (ReHo) can provide a fast method for mapping regional activity across the whole brain. Little has been previously published about where or how spontaneous activity differs between MCI and AD, although many previous fMRI studies have shown that the activity pattern is altered in MCI/AD. In the present study, we first used the ReHo method to explore differences in regional spontaneous activities throughout the whole brain between normal controls (NC) and people with MCI and with AD. A one-way ANOVA was performed to determine the regions in which the ReHo differs between the three groups, and then a post hoc analysis was performed to evaluate differences in the pattern among the three groups. Finally a correlation analysis was done between the ReHo index of these regions and clinical variables in order to evaluate the relationship between ReHo and cognitive measures in the AD and MCI groups. An exploratory classification analysis also demonstrated that ReHo measures were able to correctly separate subjects in 71.4% of the cases. Altered brain spontaneous activations were found in the medial prefrontal cortex, the bilateral posterior cingulate gyrus/precuneus and the left inferior parietal lobule (IPL) in both MCI and AD. In MCI, the ReHo index in the left IPL was higher than that of the NC, which could indicate the presence of a compensatory mechanism in MCI. More obviously, the correlation analysis indicated that the lower the memory and other cognitive abilities, the lower the ReHo in patients with MCI and AD. Combining our findings with the results in earlier studies, we propose that the spontaneous activity pattern in the resting state could potentially be used as a clinical marker for MCI/AD. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/21907292/Altered_spontaneous_activity_in_Alzheimer's_disease_and_mild_cognitive_impairment_revealed_by_Regional_Homogeneity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(11)00966-9 DB - PRIME DP - Unbound Medicine ER -