Tags

Type your tag names separated by a space and hit enter

Healing of grade-II and III oesophagitis through motility stimulation with cisapride.
Digestion. 1990; 45(2):109-14.D

Abstract

The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four times a day (n = 11) or placebo (n = 8). Cisapride was superior to placebo with regard to mucosal healing (p less than 0.001) and symptomatic improvement (p less than 0.05): at the end of treatment, healing (grade 0) was observed in 8 cisapride patients, against 1 placebo patient, and reflux symptoms had disappeared in 7 and 1 patients, respectively. In conclusion, cisapride was of significant benefit to oesophagitis patients and was well tolerated.

Authors+Show Affiliations

Gastroenterological Unit of O.L.V. Hospital, Aalst, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2190850

Citation

Lepoutre, L, et al. "Healing of grade-II and III Oesophagitis Through Motility Stimulation With Cisapride." Digestion, vol. 45, no. 2, 1990, pp. 109-14.
Lepoutre L, Van der Spek P, Vanderlinden I, et al. Healing of grade-II and III oesophagitis through motility stimulation with cisapride. Digestion. 1990;45(2):109-14.
Lepoutre, L., Van der Spek, P., Vanderlinden, I., Bollen, J., & Laukens, P. (1990). Healing of grade-II and III oesophagitis through motility stimulation with cisapride. Digestion, 45(2), 109-14.
Lepoutre L, et al. Healing of grade-II and III Oesophagitis Through Motility Stimulation With Cisapride. Digestion. 1990;45(2):109-14. PubMed PMID: 2190850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healing of grade-II and III oesophagitis through motility stimulation with cisapride. AU - Lepoutre,L, AU - Van der Spek,P, AU - Vanderlinden,I, AU - Bollen,J, AU - Laukens,P, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 109 EP - 14 JF - Digestion JO - Digestion VL - 45 IS - 2 N2 - The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four times a day (n = 11) or placebo (n = 8). Cisapride was superior to placebo with regard to mucosal healing (p less than 0.001) and symptomatic improvement (p less than 0.05): at the end of treatment, healing (grade 0) was observed in 8 cisapride patients, against 1 placebo patient, and reflux symptoms had disappeared in 7 and 1 patients, respectively. In conclusion, cisapride was of significant benefit to oesophagitis patients and was well tolerated. SN - 0012-2823 UR - https://www.unboundmedicine.com/medline/citation/2190850/Healing_of_grade_II_and_III_oesophagitis_through_motility_stimulation_with_cisapride_ L2 - https://www.karger.com?DOI=10.1159/000200231 DB - PRIME DP - Unbound Medicine ER -