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Correlation of increased fundus autofluorescence signals at closed macula with visual prognosis after successful macular hole surgery.
Retina. 2012 Feb; 32(2):281-8.R

Abstract

PURPOSE

To study the significance of the increased fundus autofluorescence (FAF) signals at closed macula with spectral-domain optical coherence tomography and visual prognosis after successful surgery in eyes with idiopathic full-thickness macular holes (MHs).

METHODS

Seventy-eight eyes of 78 consecutive patients with full-thickness MHs underwent successful standard vitrectomy, with internal limiting membrane peeling and followed by 10% sulfur hexafluoride gas injection. Simultaneous FAF and optical coherence tomography images were recorded at 10 days, and 1, 3, and 6 months postoperatively, using a combined spectral-domain optical coherence tomography-fluorescein angiography device (Spectralis™/HRA Heidelberg Retina Angiograph 2). The appearance of increased FAF in the macula postoperatively and the relationship of FAF and optical coherence tomography findings to best-corrected visual acuity were examined.

RESULTS

Stage 2, 3, and 4 MHs were present in 31, 29, and 18 eyes, respectively. The median patient age was 66 years, with a range of 54 to 79 years. In all patients, the MHs were successfully closed, and the preoperative increased FAF corresponding to MH disappeared 10 days after surgery. In 36 eyes (46.2%), however, hyperautofluorescence again appeared in the macular area 1 month postoperatively. This hyperautofluorescence was significantly associated with the recovery of the external limiting membrane lines at the fovea 1 month after surgery (P = 0.001, multiple logistic regression analysis). Also, this recovery of the external limiting membrane lines 1 month postoperatively was significantly associated with the recovery of photoreceptor inner and outer segment junction line 3 months postoperatively at the fovea (P < 0.001, Fisher exact test). Moreover, a good best-corrected visual acuity of 20/28 or better at 6 months after surgery was significantly associated with hyperautofluorescence in the macula 1 month postoperatively, the recovery of the photoreceptor inner and outer segment lines at the fovea 3 months postoperatively, and preoperative good visual acuity (P < 0.05, multiple logistic regression analysis).

CONCLUSION

In full-thickness MHs, 46.2% of our patients showed increased FAF in the macula 1 month after successful MH surgery. This hyperautofluorescence could be a sign of good visual prognosis postoperatively.

Authors+Show Affiliations

Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan. chappi@kms.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21909053

Citation

Shiragami, Chieko, et al. "Correlation of Increased Fundus Autofluorescence Signals at Closed Macula With Visual Prognosis After Successful Macular Hole Surgery." Retina (Philadelphia, Pa.), vol. 32, no. 2, 2012, pp. 281-8.
Shiragami C, Shiraga F, Nitta E, et al. Correlation of increased fundus autofluorescence signals at closed macula with visual prognosis after successful macular hole surgery. Retina. 2012;32(2):281-8.
Shiragami, C., Shiraga, F., Nitta, E., Fukuda, K., & Yamaji, H. (2012). Correlation of increased fundus autofluorescence signals at closed macula with visual prognosis after successful macular hole surgery. Retina (Philadelphia, Pa.), 32(2), 281-8. https://doi.org/10.1097/IAE.0b013e31821e208f
Shiragami C, et al. Correlation of Increased Fundus Autofluorescence Signals at Closed Macula With Visual Prognosis After Successful Macular Hole Surgery. Retina. 2012;32(2):281-8. PubMed PMID: 21909053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of increased fundus autofluorescence signals at closed macula with visual prognosis after successful macular hole surgery. AU - Shiragami,Chieko, AU - Shiraga,Fumio, AU - Nitta,Eri, AU - Fukuda,Kouki, AU - Yamaji,Hidetaka, PY - 2011/9/13/entrez PY - 2011/9/13/pubmed PY - 2012/4/5/medline SP - 281 EP - 8 JF - Retina (Philadelphia, Pa.) JO - Retina VL - 32 IS - 2 N2 - PURPOSE: To study the significance of the increased fundus autofluorescence (FAF) signals at closed macula with spectral-domain optical coherence tomography and visual prognosis after successful surgery in eyes with idiopathic full-thickness macular holes (MHs). METHODS: Seventy-eight eyes of 78 consecutive patients with full-thickness MHs underwent successful standard vitrectomy, with internal limiting membrane peeling and followed by 10% sulfur hexafluoride gas injection. Simultaneous FAF and optical coherence tomography images were recorded at 10 days, and 1, 3, and 6 months postoperatively, using a combined spectral-domain optical coherence tomography-fluorescein angiography device (Spectralis™/HRA Heidelberg Retina Angiograph 2). The appearance of increased FAF in the macula postoperatively and the relationship of FAF and optical coherence tomography findings to best-corrected visual acuity were examined. RESULTS: Stage 2, 3, and 4 MHs were present in 31, 29, and 18 eyes, respectively. The median patient age was 66 years, with a range of 54 to 79 years. In all patients, the MHs were successfully closed, and the preoperative increased FAF corresponding to MH disappeared 10 days after surgery. In 36 eyes (46.2%), however, hyperautofluorescence again appeared in the macular area 1 month postoperatively. This hyperautofluorescence was significantly associated with the recovery of the external limiting membrane lines at the fovea 1 month after surgery (P = 0.001, multiple logistic regression analysis). Also, this recovery of the external limiting membrane lines 1 month postoperatively was significantly associated with the recovery of photoreceptor inner and outer segment junction line 3 months postoperatively at the fovea (P < 0.001, Fisher exact test). Moreover, a good best-corrected visual acuity of 20/28 or better at 6 months after surgery was significantly associated with hyperautofluorescence in the macula 1 month postoperatively, the recovery of the photoreceptor inner and outer segment lines at the fovea 3 months postoperatively, and preoperative good visual acuity (P < 0.05, multiple logistic regression analysis). CONCLUSION: In full-thickness MHs, 46.2% of our patients showed increased FAF in the macula 1 month after successful MH surgery. This hyperautofluorescence could be a sign of good visual prognosis postoperatively. SN - 1539-2864 UR - https://www.unboundmedicine.com/medline/citation/21909053/Correlation_of_increased_fundus_autofluorescence_signals_at_closed_macula_with_visual_prognosis_after_successful_macular_hole_surgery_ L2 - https://doi.org/10.1097/IAE.0b013e31821e208f DB - PRIME DP - Unbound Medicine ER -