DNA reorientation on Au nanoparticles: label-free detection of hybridization by surface enhanced Raman spectroscopy.Chem Commun (Camb). 2011 Oct 21; 47(39):10966-8.CC
DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.