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A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women.
Cancer Causes Control 2011; 22(12):1627-37CC

Abstract

Although laboratory studies linked zinc and heme iron to colorectal cancer, epidemiologic evidence is limited. We prospectively examined these associations in the Nurses' Health Study and Health Professionals Follow-up Study. We used Cox proportional hazards regression analyses to calculate cohort-specific relative risks (RRs) and pooled results using a fixed-effects model. We documented 2,114 incident colorectal cancer cases during up to 22 years of follow-up. Compared highest to lowest quintile of dietary zinc intake, the pooled multivariable RRs (95% CIs) were 0.86 (0.73, 1.02) for colorectal cancer, 0.92 (0.76, 1.11) for colon cancer, and 0.68 (0.47, 0.99) for rectal cancer. The significant inverse association between dietary zinc intake and risk of rectal cancer was mainly driven by data in women, although the difference in the sex-specific results was not statistically significant. For the same comparison, the pooled multivariable RRs (95% CIs) for heme iron were 1.10 (0.93, 1.30) for colorectal cancer, 1.06 (0.88, 1.29) for colon cancer, and 1.20 (0.83, 1.75) for rectal cancer. These associations were not significantly modified by alcohol consumption, body mass index, physical activity, menopausal status, or postmenopausal hormone use. Total zinc intake, total iron intake, dietary iron intake, and zinc or iron supplement uses were largely not associated with colorectal cancer risk. Our study does not support strong roles of zinc and heme iron intake in colorectal cancer risk; however, a suggestive inverse association of dietary zinc intake with rectal cancer risk in women requires further study.

Authors+Show Affiliations

Channing Laboratory at Landmark Center (West Wing), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA. xuehong.zhang@channing.harvard.edu

Pub Type(s)

Historical Article
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21909950

Citation

Zhang, Xuehong, et al. "A Prospective Study of Intakes of Zinc and Heme Iron and Colorectal Cancer Risk in Men and Women." Cancer Causes & Control : CCC, vol. 22, no. 12, 2011, pp. 1627-37.
Zhang X, Giovannucci EL, Smith-Warner SA, et al. A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women. Cancer Causes Control. 2011;22(12):1627-37.
Zhang, X., Giovannucci, E. L., Smith-Warner, S. A., Wu, K., Fuchs, C. S., Pollak, M., ... Ma, J. (2011). A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women. Cancer Causes & Control : CCC, 22(12), pp. 1627-37. doi:10.1007/s10552-011-9839-z.
Zhang X, et al. A Prospective Study of Intakes of Zinc and Heme Iron and Colorectal Cancer Risk in Men and Women. Cancer Causes Control. 2011;22(12):1627-37. PubMed PMID: 21909950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women. AU - Zhang,Xuehong, AU - Giovannucci,Edward L, AU - Smith-Warner,Stephanie A, AU - Wu,Kana, AU - Fuchs,Charles S, AU - Pollak,Michael, AU - Willett,Walter C, AU - Ma,Jing, Y1 - 2011/09/11/ PY - 2011/05/09/received PY - 2011/08/27/accepted PY - 2011/9/13/entrez PY - 2011/9/13/pubmed PY - 2012/2/18/medline SP - 1627 EP - 37 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 22 IS - 12 N2 - Although laboratory studies linked zinc and heme iron to colorectal cancer, epidemiologic evidence is limited. We prospectively examined these associations in the Nurses' Health Study and Health Professionals Follow-up Study. We used Cox proportional hazards regression analyses to calculate cohort-specific relative risks (RRs) and pooled results using a fixed-effects model. We documented 2,114 incident colorectal cancer cases during up to 22 years of follow-up. Compared highest to lowest quintile of dietary zinc intake, the pooled multivariable RRs (95% CIs) were 0.86 (0.73, 1.02) for colorectal cancer, 0.92 (0.76, 1.11) for colon cancer, and 0.68 (0.47, 0.99) for rectal cancer. The significant inverse association between dietary zinc intake and risk of rectal cancer was mainly driven by data in women, although the difference in the sex-specific results was not statistically significant. For the same comparison, the pooled multivariable RRs (95% CIs) for heme iron were 1.10 (0.93, 1.30) for colorectal cancer, 1.06 (0.88, 1.29) for colon cancer, and 1.20 (0.83, 1.75) for rectal cancer. These associations were not significantly modified by alcohol consumption, body mass index, physical activity, menopausal status, or postmenopausal hormone use. Total zinc intake, total iron intake, dietary iron intake, and zinc or iron supplement uses were largely not associated with colorectal cancer risk. Our study does not support strong roles of zinc and heme iron intake in colorectal cancer risk; however, a suggestive inverse association of dietary zinc intake with rectal cancer risk in women requires further study. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/21909950/A_prospective_study_of_intakes_of_zinc_and_heme_iron_and_colorectal_cancer_risk_in_men_and_women_ L2 - https://doi.org/10.1007/s10552-011-9839-z DB - PRIME DP - Unbound Medicine ER -