Tags

Type your tag names separated by a space and hit enter

Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - a randomized controlled trial.
Eur J Oncol Nurs. 2012 Sep; 16(4):339-44.EJ

Abstract

PURPOSE OF THE RESEARCH

The goal of this study was to assess the effect of oral cryotherapy on the development of oral mucositis related to infusion of 5-fluorouracil (5-FU) with leucovorin.

METHOD

This study, a randomized controlled trial with random assignments to the experimental and control groups, was conducted with cancer patients. The study included 60 patients; 30 patients in the study group were instructed to hold ice cubes in their mouth shortly before, during, and shortly after infusion of 5-FU with leucovorin, the 30 patients in the control group received routine care. Oral mucositis in the patients was evaluated at 7, 14, and 21 days after chemotherapy. For analysis of data, chi-square, Fisher's tests were used; p < 0.05 was accepted as statistically significant.

RESULTS

In the majority of patients receiving cryotherapy, oral mucositis was not observed (Grade 0) at 7 and 14 days. Similarly, incidence of Grades 1, 2, and 3 oral mucositis in the experimental group was quite a bit lower when compared to the control group (p < 0.05). On day 21, no statistically significant difference between the experimental and control groups was determined based on the development of oral mucositis (p > 0.05).

CONCLUSIONS

We found that oral cryotherapy has a significant contribution to the protection of oral health by reducing mucositis score according to the WHO mucositis scale, especially on the 7th and 14th days. Nurses' awareness of how cryotherapy can affect patients and options for resolving problems will enable them to provide a higher standard of individualized care.

Authors+Show Affiliations

Gaziantep Blood Center, Gaziantep, TR-27310, Turkey. nilselgun@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21911313

Citation

Katrancı, Nilgün, et al. "Evaluation of the Effect of Cryotherapy in Preventing Oral Mucositis Associated With Chemotherapy - a Randomized Controlled Trial." European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, vol. 16, no. 4, 2012, pp. 339-44.
Katrancı N, Ovayolu N, Ovayolu O, et al. Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - a randomized controlled trial. Eur J Oncol Nurs. 2012;16(4):339-44.
Katrancı, N., Ovayolu, N., Ovayolu, O., & Sevinc, A. (2012). Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - a randomized controlled trial. European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, 16(4), 339-44. https://doi.org/10.1016/j.ejon.2011.07.008
Katrancı N, et al. Evaluation of the Effect of Cryotherapy in Preventing Oral Mucositis Associated With Chemotherapy - a Randomized Controlled Trial. Eur J Oncol Nurs. 2012;16(4):339-44. PubMed PMID: 21911313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - a randomized controlled trial. AU - Katrancı,Nilgün, AU - Ovayolu,Nimet, AU - Ovayolu,Ozlem, AU - Sevinc,Alper, Y1 - 2011/09/10/ PY - 2011/03/22/received PY - 2011/07/20/revised PY - 2011/07/23/accepted PY - 2011/9/14/entrez PY - 2011/9/14/pubmed PY - 2012/10/20/medline SP - 339 EP - 44 JF - European journal of oncology nursing : the official journal of European Oncology Nursing Society JO - Eur J Oncol Nurs VL - 16 IS - 4 N2 - PURPOSE OF THE RESEARCH: The goal of this study was to assess the effect of oral cryotherapy on the development of oral mucositis related to infusion of 5-fluorouracil (5-FU) with leucovorin. METHOD: This study, a randomized controlled trial with random assignments to the experimental and control groups, was conducted with cancer patients. The study included 60 patients; 30 patients in the study group were instructed to hold ice cubes in their mouth shortly before, during, and shortly after infusion of 5-FU with leucovorin, the 30 patients in the control group received routine care. Oral mucositis in the patients was evaluated at 7, 14, and 21 days after chemotherapy. For analysis of data, chi-square, Fisher's tests were used; p < 0.05 was accepted as statistically significant. RESULTS: In the majority of patients receiving cryotherapy, oral mucositis was not observed (Grade 0) at 7 and 14 days. Similarly, incidence of Grades 1, 2, and 3 oral mucositis in the experimental group was quite a bit lower when compared to the control group (p < 0.05). On day 21, no statistically significant difference between the experimental and control groups was determined based on the development of oral mucositis (p > 0.05). CONCLUSIONS: We found that oral cryotherapy has a significant contribution to the protection of oral health by reducing mucositis score according to the WHO mucositis scale, especially on the 7th and 14th days. Nurses' awareness of how cryotherapy can affect patients and options for resolving problems will enable them to provide a higher standard of individualized care. SN - 1532-2122 UR - https://www.unboundmedicine.com/medline/citation/21911313/Evaluation_of_the_effect_of_cryotherapy_in_preventing_oral_mucositis_associated_with_chemotherapy___a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1462-3889(11)00116-5 DB - PRIME DP - Unbound Medicine ER -