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Effect of Helicobacter pylori eradication therapy in iron deficiency anaemia of pregnancy - a pilot study.
Indian J Med Res. 2011 Aug; 134:224-31.IJ

Abstract

BACKGROUND & OBJECTIVES

Despite routine iron supplementation and promotion of diet modification, iron deficiency anaemia (IDA) remains widely prevalent in our antenatal population. Recent studies in pediatric population have highlighted the role of Helicobacter pylori infection in IDA. This study was undertaken to study the effect of eradication therapy in H. pylori infected pregnant women with IDA.

METHODS

Randomized placebo-controlled double blind clinical trial was done on 40 antenatal women between 14-30 wk gestation, with mild to moderate IDA and having H. pylori infection, as detected by stool antigen test. These women were randomly divided into group I (n=20): H. pylori treatment group (amoxicillin, clarithromycin, omeprazole for 2 wk) and group II (n=20): placebo group. Both groups received therapeutic doses of iron and folic acid. Outcome measures were improvement in haematological parameters and serum iron profile after 6 wk of oral iron therapy.

RESULTS

The prevalence of iron deficiency in pregnant women with mild to moderate anaemia was 39.8 per cent (95% CI 35.7, 44.3); and 62.5 per cent (95% CI 52, 73) of these pregnant women with IDA were infected with H. pylori. After 6 wk of therapeutic oral iron and folic acid supplementation, the rise in haemoglobin, packed cell volume, serum iron and percentage transferrin saturation was significantly (P<0.05) higher in the group given H. pylori eradication therapy as compared to the placebo group.

INTERPRETATION & CONCLUSIONS

Our results showed a high occurrence of H. pylori infection in pregnant women with IDA. Eradication therapy resulted in significantly better response to oral iron supplementation among H. pylori infected pregnant women with IDA.

Authors+Show Affiliations

Department of Obstetrics & Gynecology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21911976

Citation

Malik, Ria, et al. "Effect of Helicobacter Pylori Eradication Therapy in Iron Deficiency Anaemia of Pregnancy - a Pilot Study." The Indian Journal of Medical Research, vol. 134, 2011, pp. 224-31.
Malik R, Guleria K, Kaur I, et al. Effect of Helicobacter pylori eradication therapy in iron deficiency anaemia of pregnancy - a pilot study. Indian J Med Res. 2011;134:224-31.
Malik, R., Guleria, K., Kaur, I., Sikka, M., & Radhakrishnan, G. (2011). Effect of Helicobacter pylori eradication therapy in iron deficiency anaemia of pregnancy - a pilot study. The Indian Journal of Medical Research, 134, 224-31.
Malik R, et al. Effect of Helicobacter Pylori Eradication Therapy in Iron Deficiency Anaemia of Pregnancy - a Pilot Study. Indian J Med Res. 2011;134:224-31. PubMed PMID: 21911976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Helicobacter pylori eradication therapy in iron deficiency anaemia of pregnancy - a pilot study. AU - Malik,Ria, AU - Guleria,Kiran, AU - Kaur,Iqbal, AU - Sikka,Meera, AU - Radhakrishnan,Gita, PY - 2011/9/14/entrez PY - 2011/9/14/pubmed PY - 2012/1/20/medline SP - 224 EP - 31 JF - The Indian journal of medical research JO - Indian J Med Res VL - 134 N2 - BACKGROUND & OBJECTIVES: Despite routine iron supplementation and promotion of diet modification, iron deficiency anaemia (IDA) remains widely prevalent in our antenatal population. Recent studies in pediatric population have highlighted the role of Helicobacter pylori infection in IDA. This study was undertaken to study the effect of eradication therapy in H. pylori infected pregnant women with IDA. METHODS: Randomized placebo-controlled double blind clinical trial was done on 40 antenatal women between 14-30 wk gestation, with mild to moderate IDA and having H. pylori infection, as detected by stool antigen test. These women were randomly divided into group I (n=20): H. pylori treatment group (amoxicillin, clarithromycin, omeprazole for 2 wk) and group II (n=20): placebo group. Both groups received therapeutic doses of iron and folic acid. Outcome measures were improvement in haematological parameters and serum iron profile after 6 wk of oral iron therapy. RESULTS: The prevalence of iron deficiency in pregnant women with mild to moderate anaemia was 39.8 per cent (95% CI 35.7, 44.3); and 62.5 per cent (95% CI 52, 73) of these pregnant women with IDA were infected with H. pylori. After 6 wk of therapeutic oral iron and folic acid supplementation, the rise in haemoglobin, packed cell volume, serum iron and percentage transferrin saturation was significantly (P<0.05) higher in the group given H. pylori eradication therapy as compared to the placebo group. INTERPRETATION & CONCLUSIONS: Our results showed a high occurrence of H. pylori infection in pregnant women with IDA. Eradication therapy resulted in significantly better response to oral iron supplementation among H. pylori infected pregnant women with IDA. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/21911976/Effect_of_Helicobacter_pylori_eradication_therapy_in_iron_deficiency_anaemia_of_pregnancy___a_pilot_study_ L2 - http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2011;volume=134;issue=2;spage=224;epage=231;aulast=Malik DB - PRIME DP - Unbound Medicine ER -