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Analgesic and anti-inflammatory activities of the aqueous stem and leaf extract of Asystasia gangetica (Linn) T. Anderson.
Nig Q J Hosp Med. 2011 Apr-Jun; 21(2):129-34.NQ

Abstract

BACKGROUND

Asystasia gangetica (Linn) T. Anderson [family Acanthaceae] is used commonly in the sub-tropics and tropics for the management of inflammatory and algesic conditions.

OBJECTIVE

The study was done to evaluate the analgesic and inflammatory activity of the aqueous stem and leaf extract of Asystasia gangetica.

METHODS

The analgesic effect of the aqueous stem and leaf extract of Asystasia gangetica (25, 50, 100 and 200 mg/kg) was evaluated in rats and mice using the acetic acid induced writhing, cold water tail flick and hot plate models. Its anti-inflammatory effect was evaluated using carrageenan induced rat paw oedema and xylene induced mouse ear oedema models.

RESULTS

The aqueous stem and leaf extract of Asystasia gangetica (25-200 mg/kg) significantly (p < 0.05) reduced the number of writhes in the acetic acid induced writhing test. At 100 mg/kg, it produced an increase in pain threshold comparable to that produced by morphine (10 mg/kg) in the tail flick test and peak analgesia at 200 mg/kg in the hot plate test. The extract (25-200 mg/kg) also produced significant (p < 0.05) inhibition of oedema comparable to indomethacin (10 mg/kg) in the carrageenan induced paw oedema model. The extract (200 mg/kg) produced a significant inhibitory effect (p < 0.05) comparable to that produced by 1 mg/kg dexamethasone in the xylene induced mouse ear oedema model. Preliminary phytochemical screening showed that the extract contains alkaloids, tannins, cardiac glycosides and flavonoids. It did not produce mortality or any visible sign of lethality 24 hours after single oral administration of 10 g/kg.

CONCLUSION

The results show that the aqueous stem and feaf extract of Asystasia gangetica possesses analgesic and antiinflammatory activities.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, PMB 12003, Idiaraba, Surulere, Lagos, Nigeria. ooadey@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21913510

Citation

Adeyemi, Olufunmilayo O., et al. "Analgesic and Anti-inflammatory Activities of the Aqueous Stem and Leaf Extract of Asystasia Gangetica (Linn) T. Anderson." Nigerian Quarterly Journal of Hospital Medicine, vol. 21, no. 2, 2011, pp. 129-34.
Adeyemi OO, Aigbe FR, Uyaiabasi NG. Analgesic and anti-inflammatory activities of the aqueous stem and leaf extract of Asystasia gangetica (Linn) T. Anderson. Nig Q J Hosp Med. 2011;21(2):129-34.
Adeyemi, O. O., Aigbe, F. R., & Uyaiabasi, N. G. (2011). Analgesic and anti-inflammatory activities of the aqueous stem and leaf extract of Asystasia gangetica (Linn) T. Anderson. Nigerian Quarterly Journal of Hospital Medicine, 21(2), 129-34.
Adeyemi OO, Aigbe FR, Uyaiabasi NG. Analgesic and Anti-inflammatory Activities of the Aqueous Stem and Leaf Extract of Asystasia Gangetica (Linn) T. Anderson. Nig Q J Hosp Med. 2011 Apr-Jun;21(2):129-34. PubMed PMID: 21913510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic and anti-inflammatory activities of the aqueous stem and leaf extract of Asystasia gangetica (Linn) T. Anderson. AU - Adeyemi,Olufunmilayo O, AU - Aigbe,Flora R, AU - Uyaiabasi,Noblefather G, PY - 2011/9/15/entrez PY - 2011/9/15/pubmed PY - 2011/10/6/medline SP - 129 EP - 34 JF - Nigerian quarterly journal of hospital medicine JO - Nig Q J Hosp Med VL - 21 IS - 2 N2 - BACKGROUND: Asystasia gangetica (Linn) T. Anderson [family Acanthaceae] is used commonly in the sub-tropics and tropics for the management of inflammatory and algesic conditions. OBJECTIVE: The study was done to evaluate the analgesic and inflammatory activity of the aqueous stem and leaf extract of Asystasia gangetica. METHODS: The analgesic effect of the aqueous stem and leaf extract of Asystasia gangetica (25, 50, 100 and 200 mg/kg) was evaluated in rats and mice using the acetic acid induced writhing, cold water tail flick and hot plate models. Its anti-inflammatory effect was evaluated using carrageenan induced rat paw oedema and xylene induced mouse ear oedema models. RESULTS: The aqueous stem and leaf extract of Asystasia gangetica (25-200 mg/kg) significantly (p < 0.05) reduced the number of writhes in the acetic acid induced writhing test. At 100 mg/kg, it produced an increase in pain threshold comparable to that produced by morphine (10 mg/kg) in the tail flick test and peak analgesia at 200 mg/kg in the hot plate test. The extract (25-200 mg/kg) also produced significant (p < 0.05) inhibition of oedema comparable to indomethacin (10 mg/kg) in the carrageenan induced paw oedema model. The extract (200 mg/kg) produced a significant inhibitory effect (p < 0.05) comparable to that produced by 1 mg/kg dexamethasone in the xylene induced mouse ear oedema model. Preliminary phytochemical screening showed that the extract contains alkaloids, tannins, cardiac glycosides and flavonoids. It did not produce mortality or any visible sign of lethality 24 hours after single oral administration of 10 g/kg. CONCLUSION: The results show that the aqueous stem and feaf extract of Asystasia gangetica possesses analgesic and antiinflammatory activities. SN - 0189-2657 UR - https://www.unboundmedicine.com/medline/citation/21913510/Analgesic_and_anti_inflammatory_activities_of_the_aqueous_stem_and_leaf_extract_of_Asystasia_gangetica__Linn__T__Anderson_ L2 - https://medlineplus.gov/edema.html DB - PRIME DP - Unbound Medicine ER -